2. Gene
  3. Ddr1 - discoidin domain receptor family, member 1 Gene

Ddr1 - discoidin domain receptor family, member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cak; Nep; PTK3A; CD167a; 6030432F18

Gene ID: 12305 | Gene type: protein coding

About Ddr1

Chromosome 17: 35,992,459-36,015,513 reverse strand.GRCm39:CM001010.3

This gene has 12 transcripts (splice variants), 196 orthologues, 53 paralogues and is associated with 20 phenotypes. Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues.

Summary

Enables collagen binding activity. Involved in several processes, including smooth muscle cell migration; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (Discoidin Domain Receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ddr1 Products(4)

mRNA Protein Name
NM_007584.3 NP_031610.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_172962.1 NP_766550.1 epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001198833.1 NP_001185762.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001198831.1 NP_001185760.1 epithelial discoidin domain-containing receptor 1 isoform 1 precursor

Ddr1 Protein Structure

FA58C

FA58C: cd00057 (57 - 184)

PKc_like

PKc_like: cl21453 (601 - 904)

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  • 911 a.a.
Protein Preferred Names Protein Names

epithelial discoidin domain-containing receptor 1

CD167 antigen-like family member A

cell adhesion kinase

discoidin receptor tyrosine kinase

epithelial discoidin domain receptor 1

protein-tyrosine kinase MPK-6

tyrosine kinase DDR

tyrosine-protein kinase CAK

Recombinant Ddr1 Proteins

Cat. No. Product Name Accession Purity
HY-P75301 DDR1 Protein, Mouse (sf9, His-GST) Q03146-2 (L444-V874) ≥95%
HY-P75302 DDR1 Protein, Mouse (HEK293, His) Q03146-2 (D20-T414) ≥95%
HY-P75303 DDR1 Protein, Mouse (HEK293, Fc) Q03146-2 (M1-T414) ≥95%
HY-P77639 DDR1 Protein, Mouse (HEK293, C-His) Q03146-2 (D20-A414) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16961 Sitravatinib Inhibitor 99.59% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135401 VU6015929 Inhibitor 99.26% Unkown
HY-133670 DDR1-IN-6 Inhibitor 98.16% Unkown
HY-114173 DDR1-IN-4 Inhibitor 98.01% Unkown
HY-133669 DDR1-IN-5 Inhibitor 99.27% Unkown
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / Unkown
HY-156552 DDR1/2 inhibitor-2 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddr1 NCBI NCBI:780
Rattus norvegicus Ddr1 NCBI NCBI:25678