DDR1-IN-11

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DDR1-IN-11 (Compound 4) is an inhibitor of Discoidin domain receptor 1 (DDR1) with an IC₅₀ of 46.16 nM. DDR1-IN-11 can achieve an inhibition rate of 99.86% against Z-138 cells at a concentration of 10 μM, and it can be used in the research of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

DDR1-IN-11 Chemical Structure

CAS No. : 639089-54-6

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DDR1 DDR2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

DDR1

46.16 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
697	IC₅₀	0.025 μM Compound: VX-680	SANGER: Inhibition of human 697 cell growth in a cell viability assay. SANGER: Inhibition of human 697 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
8-MG-BA	IC₅₀	9.328 μM Compound: VX-680	SANGER: Inhibition of human 8-MG-BA cell growth in a cell viability assay. SANGER: Inhibition of human 8-MG-BA cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A101D	IC₅₀	1.874 μM Compound: VX-680	SANGER: Inhibition of human A101D cell growth in a cell viability assay. SANGER: Inhibition of human A101D cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A253 cell line	IC₅₀	33.585 μM Compound: VX-680	SANGER: Inhibition of human A253 cell growth in a cell viability assay. SANGER: Inhibition of human A253 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A388	IC₅₀	0.341 μM Compound: VX-680	SANGER: Inhibition of human A388 cell growth in a cell viability assay. SANGER: Inhibition of human A388 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A3-KAW	IC₅₀	12.324 μM Compound: VX-680	SANGER: Inhibition of human A3-KAW cell growth in a cell viability assay. SANGER: Inhibition of human A3-KAW cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A-431	IC₅₀	0.24 μM Compound: VX-680	Antiproliferative activity against human A431 cells after 48 hrs by CCK8 assay Antiproliferative activity against human A431 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
A-431	IC₅₀	0.24 μM Compound: VX-680, MK-0457	Antiproliferative activity against human A431 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human A431 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
A498	IC₅₀	135.909 μM Compound: VX-680	SANGER: Inhibition of human A498 cell growth in a cell viability assay. SANGER: Inhibition of human A498 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A4-Fuk	IC₅₀	0.116 μM Compound: VX-680	SANGER: Inhibition of human A4-Fuk cell growth in a cell viability assay. SANGER: Inhibition of human A4-Fuk cell growth in a cell viability assay.	10.6019/CHEMBL1201861
A549	GI₅₀	35.8 μM Compound: VX-680	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30502115]
A549	IC₅₀	15.06 μM Compound: VX-680	Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35476959]
A549	IC₅₀	19.4 μM Compound: VX-680	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25812967]
A549	IC₅₀	3.05 μM Compound: VX-680, MK-0457	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
A549	IC₅₀	3.9 μM Compound: VX-680	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31862411]
A549	IC₅₀	35.8 μM Compound: VX-680	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30728112]
A549	IC₅₀	6.9 μM Compound: VX680	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 32941989]
A704	IC₅₀	33.554 μM Compound: VX-680	SANGER: Inhibition of human A704 cell growth in a cell viability assay. SANGER: Inhibition of human A704 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ACN	IC₅₀	2.502 μM Compound: VX-680	SANGER: Inhibition of human ACN cell growth in a cell viability assay. SANGER: Inhibition of human ACN cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ALL-PO	IC₅₀	0.882 μM Compound: VX-680	SANGER: Inhibition of human ALL-PO cell growth in a cell viability assay. SANGER: Inhibition of human ALL-PO cell growth in a cell viability assay.	10.6019/CHEMBL1201861
AM-38	IC₅₀	348.763 μM Compound: VX-680	SANGER: Inhibition of human AM-38 cell growth in a cell viability assay. SANGER: Inhibition of human AM-38 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ARH-77	IC₅₀	61.946 μM Compound: VX-680	SANGER: Inhibition of human ARH-77 cell growth in a cell viability assay. SANGER: Inhibition of human ARH-77 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ATN-1	IC₅₀	2.029 μM Compound: VX-680	SANGER: Inhibition of human ATN-1 cell growth in a cell viability assay. SANGER: Inhibition of human ATN-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BaF3	IC₅₀	100 nM Compound: MK-0457	Antiproliferative activity against mouse BaF3 cells harbouring T315I mutant assessed as cell growth inhibition Antiproliferative activity against mouse BaF3 cells harbouring T315I mutant assessed as cell growth inhibition	[PMID: 35551036]
BaF3	IC₅₀	30 nM Compound: VX-680, MK-0457	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant	[PMID: 20604564]
BaF3	IC₅₀	5 μM Compound: VX-680, MK-0457	Inhibition of Bcr-Abl T315I mutant autophosphorylation in mouse BA/F3 cells Inhibition of Bcr-Abl T315I mutant autophosphorylation in mouse BA/F3 cells	[PMID: 20604564]
BB30-HNC	IC₅₀	0.226 μM Compound: VX-680	SANGER: Inhibition of human BB30-HNC cell growth in a cell viability assay. SANGER: Inhibition of human BB30-HNC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BB49-HNC	IC₅₀	88.838 μM Compound: VX-680	SANGER: Inhibition of human BB49-HNC cell growth in a cell viability assay. SANGER: Inhibition of human BB49-HNC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BB65-RCC	IC₅₀	1.18 μM Compound: VX-680	SANGER: Inhibition of human BB65-RCC cell growth in a cell viability assay. SANGER: Inhibition of human BB65-RCC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BC1 cell line	IC₅₀	42.673 μM Compound: VX-680	SANGER: Inhibition of human BC-1 cell growth in a cell viability assay. SANGER: Inhibition of human BC-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BC-3	IC₅₀	570.863 μM Compound: VX-680	SANGER: Inhibition of human BC-3 cell growth in a cell viability assay. SANGER: Inhibition of human BC-3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BE-13	IC₅₀	0.003 μM Compound: VX-680	SANGER: Inhibition of human BE-13 cell growth in a cell viability assay. SANGER: Inhibition of human BE-13 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Becker	IC₅₀	110.994 μM Compound: VX-680	SANGER: Inhibition of human Becker cell growth in a cell viability assay. SANGER: Inhibition of human Becker cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BL-41	IC₅₀	0.104 μM Compound: VX-680	SANGER: Inhibition of human BL-41 cell growth in a cell viability assay. SANGER: Inhibition of human BL-41 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BL-70	IC₅₀	0.39 μM Compound: VX-680	SANGER: Inhibition of human BL-70 cell growth in a cell viability assay. SANGER: Inhibition of human BL-70 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BOKU	IC₅₀	21.453 μM Compound: VX-680	SANGER: Inhibition of human BOKU cell growth in a cell viability assay. SANGER: Inhibition of human BOKU cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BT-474	IC₅₀	245.868 μM Compound: VX-680	SANGER: Inhibition of human BT-474 cell growth in a cell viability assay. SANGER: Inhibition of human BT-474 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
BV-173	IC₅₀	0.126 μM Compound: VX-680	SANGER: Inhibition of human BV-173 cell growth in a cell viability assay. SANGER: Inhibition of human BV-173 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
C2BBe1	IC₅₀	144.709 μM Compound: VX-680	SANGER: Inhibition of human C2BBe1 cell growth in a cell viability assay. SANGER: Inhibition of human C2BBe1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
C8166	IC₅₀	314.528 μM Compound: VX-680	SANGER: Inhibition of human C8166 cell growth in a cell viability assay. SANGER: Inhibition of human C8166 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CA46	IC₅₀	97.983 μM Compound: VX-680	SANGER: Inhibition of human CA46 cell growth in a cell viability assay. SANGER: Inhibition of human CA46 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CAL-148	IC₅₀	20.993 μM Compound: VX-680	SANGER: Inhibition of human CAL-148 cell growth in a cell viability assay. SANGER: Inhibition of human CAL-148 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Calu-6	IC₅₀	19.239 μM Compound: VX-680	SANGER: Inhibition of human Calu-6 cell growth in a cell viability assay. SANGER: Inhibition of human Calu-6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CAS-1	IC₅₀	76.477 μM Compound: VX-680	SANGER: Inhibition of human CAS-1 cell growth in a cell viability assay. SANGER: Inhibition of human CAS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CCRF-CEM	IC₅₀	0.653 μM Compound: VX-680	SANGER: Inhibition of human CCRF-CEM cell growth in a cell viability assay. SANGER: Inhibition of human CCRF-CEM cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CESS	IC₅₀	0.313 μM Compound: VX-680	SANGER: Inhibition of human CESS cell growth in a cell viability assay. SANGER: Inhibition of human CESS cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CGTH-W-1	IC₅₀	82.761 μM Compound: VX-680	SANGER: Inhibition of human CGTH-W-1 cell growth in a cell viability assay. SANGER: Inhibition of human CGTH-W-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CHP-126	IC₅₀	31.198 μM Compound: VX-680	SANGER: Inhibition of human CHP-126 cell growth in a cell viability assay. SANGER: Inhibition of human CHP-126 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CMK	IC₅₀	1.421 μM Compound: VX-680	SANGER: Inhibition of human CMK cell growth in a cell viability assay. SANGER: Inhibition of human CMK cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO 205	IC₅₀	0.019 μM Compound: 44, MK-0457 (VX-680)	Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay Antiproliferative activity against human COLO205 cells by [3H]thymidine uptake assay	[PMID: 19447622]
COLO-320-HSR	IC₅₀	51.416 μM Compound: VX-680	SANGER: Inhibition of human COLO-320-HSR cell growth in a cell viability assay. SANGER: Inhibition of human COLO-320-HSR cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO-668	IC₅₀	85.995 μM Compound: VX-680	SANGER: Inhibition of human COLO-668 cell growth in a cell viability assay. SANGER: Inhibition of human COLO-668 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO-684	IC₅₀	32.644 μM Compound: VX-680	SANGER: Inhibition of human COLO-684 cell growth in a cell viability assay. SANGER: Inhibition of human COLO-684 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO-800	IC₅₀	378.381 μM Compound: VX-680	SANGER: Inhibition of human COLO-800 cell growth in a cell viability assay. SANGER: Inhibition of human COLO-800 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO-824	IC₅₀	298.069 μM Compound: VX-680	SANGER: Inhibition of human COLO-824 cell growth in a cell viability assay. SANGER: Inhibition of human COLO-824 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COLO-829	IC₅₀	102.049 μM Compound: VX-680	SANGER: Inhibition of human COLO-829 cell growth in a cell viability assay. SANGER: Inhibition of human COLO-829 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COR-L279	IC₅₀	4.759 μM Compound: VX-680	SANGER: Inhibition of human COR-L279 cell growth in a cell viability assay. SANGER: Inhibition of human COR-L279 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
COR-L88	IC₅₀	45.278 μM Compound: VX-680	SANGER: Inhibition of human COR-L88 cell growth in a cell viability assay. SANGER: Inhibition of human COR-L88 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CP66-MEL	IC₅₀	63.077 μM Compound: VX-680	SANGER: Inhibition of human CP66-MEL cell growth in a cell viability assay. SANGER: Inhibition of human CP66-MEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CP67-MEL	IC₅₀	8.533 μM Compound: VX-680	SANGER: Inhibition of human CP67-MEL cell growth in a cell viability assay. SANGER: Inhibition of human CP67-MEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CPC-N	IC₅₀	61.644 μM Compound: VX-680	SANGER: Inhibition of human CPC-N cell growth in a cell viability assay. SANGER: Inhibition of human CPC-N cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CTB-1	IC₅₀	14.033 μM Compound: VX-680	SANGER: Inhibition of human CTB-1 cell growth in a cell viability assay. SANGER: Inhibition of human CTB-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CTV-1	IC₅₀	0.588 μM Compound: VX-680	SANGER: Inhibition of human CTV-1 cell growth in a cell viability assay. SANGER: Inhibition of human CTV-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
CW-2	IC₅₀	545.639 μM Compound: VX-680	SANGER: Inhibition of human CW-2 cell growth in a cell viability assay. SANGER: Inhibition of human CW-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
D-247MG	IC₅₀	84.634 μM Compound: VX-680	SANGER: Inhibition of human D-247MG cell growth in a cell viability assay. SANGER: Inhibition of human D-247MG cell growth in a cell viability assay.	10.6019/CHEMBL1201861
D-263MG	IC₅₀	157.175 μM Compound: VX-680	SANGER: Inhibition of human D-263MG cell growth in a cell viability assay. SANGER: Inhibition of human D-263MG cell growth in a cell viability assay.	10.6019/CHEMBL1201861
D283 Med	IC₅₀	256.561 μM Compound: VX-680	SANGER: Inhibition of human D-283MED cell growth in a cell viability assay. SANGER: Inhibition of human D-283MED cell growth in a cell viability assay.	10.6019/CHEMBL1201861
D-336MG	IC₅₀	118.907 μM Compound: VX-680	SANGER: Inhibition of human D-336MG cell growth in a cell viability assay. SANGER: Inhibition of human D-336MG cell growth in a cell viability assay.	10.6019/CHEMBL1201861
D-502MG	IC₅₀	186.525 μM Compound: VX-680	SANGER: Inhibition of human D-502MG cell growth in a cell viability assay. SANGER: Inhibition of human D-502MG cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Daudi	IC₅₀	5.691 μM Compound: VX-680	SANGER: Inhibition of human Daudi cell growth in a cell viability assay. SANGER: Inhibition of human Daudi cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DB	IC₅₀	332.489 μM Compound: VX-680	SANGER: Inhibition of human DB cell growth in a cell viability assay. SANGER: Inhibition of human DB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DEL	IC₅₀	1.256 μM Compound: VX-680	SANGER: Inhibition of human DEL cell growth in a cell viability assay. SANGER: Inhibition of human DEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DG-75	IC₅₀	45.158 μM Compound: VX-680	SANGER: Inhibition of human DG-75 cell growth in a cell viability assay. SANGER: Inhibition of human DG-75 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DJM-1	IC₅₀	6.347 μM Compound: VX-680	SANGER: Inhibition of human DJM-1 cell growth in a cell viability assay. SANGER: Inhibition of human DJM-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DMS-114	IC₅₀	130.131 μM Compound: VX-680	SANGER: Inhibition of human DMS-114 cell growth in a cell viability assay. SANGER: Inhibition of human DMS-114 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DMS-153	IC₅₀	12.043 μM Compound: VX-680	SANGER: Inhibition of human DMS-153 cell growth in a cell viability assay. SANGER: Inhibition of human DMS-153 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DMS-79	IC₅₀	163.774 μM Compound: VX-680	SANGER: Inhibition of human DMS-79 cell growth in a cell viability assay. SANGER: Inhibition of human DMS-79 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DOHH-2	IC₅₀	0.338 μM Compound: VX-680	SANGER: Inhibition of human DOHH-2 cell growth in a cell viability assay. SANGER: Inhibition of human DOHH-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DSH1	IC₅₀	65.758 μM Compound: VX-680	SANGER: Inhibition of human DSH1 cell growth in a cell viability assay. SANGER: Inhibition of human DSH1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
DU-145	IC₅₀	0.4 μM Compound: VX-680, MK-0457	Antiproliferative activity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human DU145 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
DU-4475	IC₅₀	1.018 μM Compound: VX-680	SANGER: Inhibition of human DU-4475 cell growth in a cell viability assay. SANGER: Inhibition of human DU-4475 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EB2	IC₅₀	446.657 μM Compound: VX-680	SANGER: Inhibition of human EB2 cell growth in a cell viability assay. SANGER: Inhibition of human EB2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EB-3	IC₅₀	60.256 μM Compound: VX-680	SANGER: Inhibition of human EB-3 cell growth in a cell viability assay. SANGER: Inhibition of human EB-3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ECC4	IC₅₀	115.642 μM Compound: VX-680	SANGER: Inhibition of human ECC4 cell growth in a cell viability assay. SANGER: Inhibition of human ECC4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EC-GI-10	IC₅₀	461.596 μM Compound: VX-680	SANGER: Inhibition of human EC-GI-10 cell growth in a cell viability assay. SANGER: Inhibition of human EC-GI-10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EHEB	IC₅₀	419.542 μM Compound: VX-680	SANGER: Inhibition of human EHEB cell growth in a cell viability assay. SANGER: Inhibition of human EHEB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EKVX	IC₅₀	199.238 μM Compound: VX-680	SANGER: Inhibition of human EKVX cell growth in a cell viability assay. SANGER: Inhibition of human EKVX cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EM-2	IC₅₀	0.266 μM Compound: VX-680	SANGER: Inhibition of human EM-2 cell growth in a cell viability assay. SANGER: Inhibition of human EM-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EOL1	IC₅₀	0.335 μM Compound: VX-680	SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES1	IC₅₀	3.923 μM Compound: VX-680	SANGER: Inhibition of human ES1 cell growth in a cell viability assay. SANGER: Inhibition of human ES1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES3	IC₅₀	36.675 μM Compound: VX-680	SANGER: Inhibition of human ES3 cell growth in a cell viability assay. SANGER: Inhibition of human ES3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES4	IC₅₀	0.911 μM Compound: VX-680	SANGER: Inhibition of human ES4 cell growth in a cell viability assay. SANGER: Inhibition of human ES4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES5	IC₅₀	209.977 μM Compound: VX-680	SANGER: Inhibition of human ES5 cell growth in a cell viability assay. SANGER: Inhibition of human ES5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES6	IC₅₀	16.236 μM Compound: VX-680	SANGER: Inhibition of human ES6 cell growth in a cell viability assay. SANGER: Inhibition of human ES6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES7	IC₅₀	154.216 μM Compound: VX-680	SANGER: Inhibition of human ES7 cell growth in a cell viability assay. SANGER: Inhibition of human ES7 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ES8	IC₅₀	0.046 μM Compound: VX-680	SANGER: Inhibition of human ES8 cell growth in a cell viability assay. SANGER: Inhibition of human ES8 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ETK-1	IC₅₀	1.136 μM Compound: VX-680	SANGER: Inhibition of human ETK-1 cell growth in a cell viability assay. SANGER: Inhibition of human ETK-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EVSA-T	IC₅₀	21.15 μM Compound: VX-680	SANGER: Inhibition of human EVSA-T cell growth in a cell viability assay. SANGER: Inhibition of human EVSA-T cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-1	IC₅₀	1.186 μM Compound: VX-680	SANGER: Inhibition of human EW-1 cell growth in a cell viability assay. SANGER: Inhibition of human EW-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-11	IC₅₀	307.692 μM Compound: VX-680	SANGER: Inhibition of human EW-11 cell growth in a cell viability assay. SANGER: Inhibition of human EW-11 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-12	IC₅₀	622.142 μM Compound: VX-680	SANGER: Inhibition of human EW-12 cell growth in a cell viability assay. SANGER: Inhibition of human EW-12 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-13	IC₅₀	54.265 μM Compound: VX-680	SANGER: Inhibition of human EW-13 cell growth in a cell viability assay. SANGER: Inhibition of human EW-13 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-16	IC₅₀	0.238 μM Compound: VX-680	SANGER: Inhibition of human EW-16 cell growth in a cell viability assay. SANGER: Inhibition of human EW-16 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-18	IC₅₀	640.681 μM Compound: VX-680	SANGER: Inhibition of human EW-18 cell growth in a cell viability assay. SANGER: Inhibition of human EW-18 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-24	IC₅₀	148.893 μM Compound: VX-680	SANGER: Inhibition of human EW-24 cell growth in a cell viability assay. SANGER: Inhibition of human EW-24 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
EW-3	IC₅₀	13.74 μM Compound: VX-680	SANGER: Inhibition of human EW-3 cell growth in a cell viability assay. SANGER: Inhibition of human EW-3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GAK	IC₅₀	77.801 μM Compound: VX-680	SANGER: Inhibition of human GAK cell growth in a cell viability assay. SANGER: Inhibition of human GAK cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GB-1	IC₅₀	2.016 μM Compound: VX-680	SANGER: Inhibition of human GB-1 cell growth in a cell viability assay. SANGER: Inhibition of human GB-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GCIY	IC₅₀	8.37 μM Compound: VX-680	SANGER: Inhibition of human GCIY cell growth in a cell viability assay. SANGER: Inhibition of human GCIY cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GDM-1	IC₅₀	38.912 μM Compound: VX-680	SANGER: Inhibition of human GDM-1 cell growth in a cell viability assay. SANGER: Inhibition of human GDM-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GI-1	IC₅₀	42.919 μM Compound: VX-680	SANGER: Inhibition of human GI-1 cell growth in a cell viability assay. SANGER: Inhibition of human GI-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GI-ME-N	IC₅₀	19.823 μM Compound: VX-680	SANGER: Inhibition of human GI-ME-N cell growth in a cell viability assay. SANGER: Inhibition of human GI-ME-N cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GOTO	IC₅₀	73.045 μM Compound: VX-680	SANGER: Inhibition of human GOTO cell growth in a cell viability assay. SANGER: Inhibition of human GOTO cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GR-ST	IC₅₀	109.992 μM Compound: VX-680	SANGER: Inhibition of human GR-ST cell growth in a cell viability assay. SANGER: Inhibition of human GR-ST cell growth in a cell viability assay.	10.6019/CHEMBL1201861
GT3TKB	IC₅₀	1.281 μM Compound: VX-680	SANGER: Inhibition of human GT3TKB cell growth in a cell viability assay. SANGER: Inhibition of human GT3TKB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HAL-01	IC₅₀	1.167 μM Compound: VX-680	SANGER: Inhibition of human HAL-01 cell growth in a cell viability assay. SANGER: Inhibition of human HAL-01 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HC-1	IC₅₀	4.695 μM Compound: VX-680	SANGER: Inhibition of human HC-1 cell growth in a cell viability assay. SANGER: Inhibition of human HC-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCC1187	IC₅₀	1.005 μM Compound: VX-680	SANGER: Inhibition of human HCC1187 cell growth in a cell viability assay. SANGER: Inhibition of human HCC1187 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCC1599	IC₅₀	0.809 μM Compound: VX-680	SANGER: Inhibition of human HCC1599 cell growth in a cell viability assay. SANGER: Inhibition of human HCC1599 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCC2157	IC₅₀	35.462 μM Compound: VX-680	SANGER: Inhibition of human HCC2157 cell growth in a cell viability assay. SANGER: Inhibition of human HCC2157 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCC2218	IC₅₀	251.321 μM Compound: VX-680	SANGER: Inhibition of human HCC2218 cell growth in a cell viability assay. SANGER: Inhibition of human HCC2218 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCE-4	IC₅₀	0.881 μM Compound: VX-680	SANGER: Inhibition of human HCE-4 cell growth in a cell viability assay. SANGER: Inhibition of human HCE-4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCE-T	IC₅₀	13.005 μM Compound: VX-680	SANGER: Inhibition of human HCE-T cell growth in a cell viability assay. SANGER: Inhibition of human HCE-T cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HCT-116	EC₅₀	120 nM Compound: 1, VX-680	Antiproliferative activity against human HCT116 cells after 96 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 96 hrs by MTS assay	[PMID: 23808327]
HCT-116	IC₅₀	0.053 μM Compound: 39, VX-680	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 18630890]
HCT-116	IC₅₀	0.3 μM Compound: VX-680	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 22572580]
HCT-116	IC₅₀	0.45 μM Compound: VX 680	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30143423]
HCT-116	IC₅₀	1.49 μM Compound: VX-680	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31862411]
HCT-116	IC₅₀	120 nM Compound: 1, VX-680	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 23808327]
HCT-116	IC₅₀	120 nM Compound: Tozasertib	Cytotoxicity against human HCT116 cells by MTS assay Cytotoxicity against human HCT116 cells by MTS assay	[PMID: 20550212]
HCT-116	IC₅₀	2.79 μM Compound: VX680	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 32941989]
HCT-116	IC₅₀	24 nM Compound: 1, VX- 680, MK-0457	Cytotoxicity against human HCT116 cells assessed as number of colonies after 10 to 14 days by colony forming assay Cytotoxicity against human HCT116 cells assessed as number of colonies after 10 to 14 days by colony forming assay	[PMID: 19143567]
HCT-116	IC₅₀	28 nM Compound: VX-680, MK-0457	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 21802948]
HCT-116	IC₅₀	4.32 μM Compound: VX-680	Antiproliferative activity against human HCT116 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HCT116 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
HCT-116	IC₅₀	4.32 μM Compound: VX-680, MK-0457	Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
HCT-116	IC₅₀	55 nM Compound: VX-680, MK-0457	Inhibition of Aurora B kinase assessed as reduction in histone H3 phosphorylation in human HCT116 cells Inhibition of Aurora B kinase assessed as reduction in histone H3 phosphorylation in human HCT116 cells	[PMID: 21802948]
HCT-15	IC₅₀	1.23 μM Compound: VX 680	Cytotoxicity against human HCT15 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30143423]
HCT-8	IC₅₀	44.6 μM Compound: VX-680	Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay Cytotoxicity against human HCT8 cells after 48 hrs by MTT assay	[PMID: 25812967]
HDLM-2	IC₅₀	380.236 μM Compound: VX-680	SANGER: Inhibition of human HDLM-2 cell growth in a cell viability assay. SANGER: Inhibition of human HDLM-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HD-MY-Z	IC₅₀	46.461 μM Compound: VX-680	SANGER: Inhibition of human HD-MY-Z cell growth in a cell viability assay. SANGER: Inhibition of human HD-MY-Z cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HEL	IC₅₀	3.632 μM Compound: VX-680	SANGER: Inhibition of human HEL cell growth in a cell viability assay. SANGER: Inhibition of human HEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HeLa	GI₅₀	46.2 μM Compound: VX-680	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30502115]
HeLa	IC₅₀	0.013 μM Compound: VX-680	Inhibition of Aurora A phosphorylation at Thr288 residue in human HeLa cells after 12 hrs by ELISA Inhibition of Aurora A phosphorylation at Thr288 residue in human HeLa cells after 12 hrs by ELISA	[PMID: 30502115]
HeLa	IC₅₀	0.148 μM Compound: VX-680	Inhibition of Aurora B phosphorylation at Thr232 residue in human HeLa cells after 12 hrs by ELISA Inhibition of Aurora B phosphorylation at Thr232 residue in human HeLa cells after 12 hrs by ELISA	[PMID: 30502115]
HeLa	IC₅₀	0.261 μM Compound: VX-680	Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA method Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA method	[PMID: 25812967]
HeLa	IC₅₀	0.453 μM Compound: VX-680	Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA method Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA method	[PMID: 25812967]
HeLa	IC₅₀	2.93 μM Compound: VX-680	Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 48 hrs by CCK8 assay	[PMID: 29358147]
HeLa	IC₅₀	2.93 μM Compound: VX-680, MK-0457	Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
HeLa	IC₅₀	27.3 μM Compound: VX-680	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25812967]
HeLa	IC₅₀	46.2 μM Compound: VX-680	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30728112]
HeLa	IC₅₀	6.24 μM Compound: VX-680	Anticancer activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Anticancer activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35476959]
HeLa	IC₅₀	9.5 μM Compound: VX-680	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 32035750]
HepG2	GI₅₀	53.3 μM Compound: VX-680	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30502115]
HepG2	IC₅₀	12.8 μM Compound: VX-680	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 32035750]
HepG2	IC₅₀	16.11 μM Compound: VX680	Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 32941989]
HepG2	IC₅₀	18.01 μM Compound: VX-680	Anticancer activity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35476959]
HepG2	IC₅₀	53.3 μM Compound: VX-680	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30728112]
HepG2	IC₅₀	63.4 μM Compound: VX-680	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 25812967]
HH	IC₅₀	17.196 μM Compound: VX-680	SANGER: Inhibition of human HH cell growth in a cell viability assay. SANGER: Inhibition of human HH cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HL-60	IC₅₀	0.0382 μM Compound: VX-680, MK-0457	Antiproliferative activity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
HL-60	IC₅₀	1.066 μM Compound: VX-680	SANGER: Inhibition of human HL-60 cell growth in a cell viability assay. SANGER: Inhibition of human HL-60 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HL-60	IC₅₀	1.88 μM Compound: VX-680	Anticancer activity against human HL-60 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Anticancer activity against human HL-60 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35476959]
HOP-62	IC₅₀	0.863 μM Compound: VX-680	SANGER: Inhibition of human HOP-62 cell growth in a cell viability assay. SANGER: Inhibition of human HOP-62 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HT	IC₅₀	136.722 μM Compound: VX-680	SANGER: Inhibition of human HT cell growth in a cell viability assay. SANGER: Inhibition of human HT cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HT-144	IC₅₀	0.638 μM Compound: VX-680	SANGER: Inhibition of human HT-144 cell growth in a cell viability assay. SANGER: Inhibition of human HT-144 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
HT-29	IC₅₀	0.15 μM Compound: 39, VX-680	Antiproliferative activity against human HT29 cells Antiproliferative activity against human HT29 cells	[PMID: 18630890]
IA-LM	IC₅₀	7.859 μM Compound: VX-680	SANGER: Inhibition of human IA-LM cell growth in a cell viability assay. SANGER: Inhibition of human IA-LM cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IM-9	IC₅₀	447.539 μM Compound: VX-680	SANGER: Inhibition of human IM-9 cell growth in a cell viability assay. SANGER: Inhibition of human IM-9 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IMR-5	IC₅₀	0.355 μM Compound: VX-680	SANGER: Inhibition of human IMR-5 cell growth in a cell viability assay. SANGER: Inhibition of human IMR-5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IST-MEL1	IC₅₀	13.579 μM Compound: VX-680	SANGER: Inhibition of human IST-MEL1 cell growth in a cell viability assay. SANGER: Inhibition of human IST-MEL1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IST-MES1	IC₅₀	19.666 μM Compound: VX-680	SANGER: Inhibition of human IST-MES1 cell growth in a cell viability assay. SANGER: Inhibition of human IST-MES1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IST-SL1	IC₅₀	2.298 μM Compound: VX-680	SANGER: Inhibition of human IST-SL1 cell growth in a cell viability assay. SANGER: Inhibition of human IST-SL1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
IST-SL2	IC₅₀	0.72 μM Compound: VX-680	SANGER: Inhibition of human IST-SL2 cell growth in a cell viability assay. SANGER: Inhibition of human IST-SL2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
JAR	IC₅₀	38.245 μM Compound: VX-680	SANGER: Inhibition of human JAR cell growth in a cell viability assay. SANGER: Inhibition of human JAR cell growth in a cell viability assay.	10.6019/CHEMBL1201861
JIYOYE	IC₅₀	15.633 μM Compound: VX-680	SANGER: Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay. SANGER: Inhibition of human JiyoyeP-2003 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
J-RT3-T3-5	IC₅₀	63.539 μM Compound: VX-680	SANGER: Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay. SANGER: Inhibition of human J-RT3-T3-5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
JVM-2	IC₅₀	72.328 μM Compound: VX-680	SANGER: Inhibition of human JVM-2 cell growth in a cell viability assay. SANGER: Inhibition of human JVM-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
JVM-3	IC₅₀	432.984 μM Compound: VX-680	SANGER: Inhibition of human JVM-3 cell growth in a cell viability assay. SANGER: Inhibition of human JVM-3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
K052	IC₅₀	0.195 μM Compound: VX-680	SANGER: Inhibition of human K052 cell growth in a cell viability assay. SANGER: Inhibition of human K052 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
K5	IC₅₀	2.403 μM Compound: VX-680	SANGER: Inhibition of human K5 cell growth in a cell viability assay. SANGER: Inhibition of human K5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
K562	IC₅₀	0.079 μM Compound: VX-680	Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay Antiproliferative activity against human K562 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
K562	IC₅₀	0.0791 μM Compound: VX-680, MK-0457	Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
K562	IC₅₀	0.435 μM Compound: VX-680	SANGER: Inhibition of human K-562 cell growth in a cell viability assay. SANGER: Inhibition of human K-562 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KALS-1	IC₅₀	8.839 μM Compound: VX-680	SANGER: Inhibition of human KALS-1 cell growth in a cell viability assay. SANGER: Inhibition of human KALS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KARPAS-299	IC₅₀	353.77 μM Compound: VX-680	SANGER: Inhibition of human KARPAS-299 cell growth in a cell viability assay. SANGER: Inhibition of human KARPAS-299 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KARPAS-422	IC₅₀	0.373 μM Compound: VX-680	SANGER: Inhibition of human KARPAS-422 cell growth in a cell viability assay. SANGER: Inhibition of human KARPAS-422 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KARPAS-45	IC₅₀	2.027 μM Compound: VX-680	SANGER: Inhibition of human KARPAS-45 cell growth in a cell viability assay. SANGER: Inhibition of human KARPAS-45 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Kasumi 1	IC₅₀	500.567 μM Compound: VX-680	SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay. SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KE-37	IC₅₀	0.521 μM Compound: VX-680	SANGER: Inhibition of human KE-37 cell growth in a cell viability assay. SANGER: Inhibition of human KE-37 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KG-1	IC₅₀	12.655 μM Compound: VX-680	SANGER: Inhibition of human KG-1 cell growth in a cell viability assay. SANGER: Inhibition of human KG-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KGN	IC₅₀	0.9 μM Compound: VX-680	SANGER: Inhibition of human KGN cell growth in a cell viability assay. SANGER: Inhibition of human KGN cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KINGS-1	IC₅₀	57.579 μM Compound: VX-680	SANGER: Inhibition of human KINGS-1 cell growth in a cell viability assay. SANGER: Inhibition of human KINGS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KLE	IC₅₀	22.19 μM Compound: VX-680	SANGER: Inhibition of human KLE cell growth in a cell viability assay. SANGER: Inhibition of human KLE cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KM12	IC₅₀	0.264 μM Compound: VX-680	SANGER: Inhibition of human KM12 cell growth in a cell viability assay. SANGER: Inhibition of human KM12 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KM-H2	IC₅₀	7.185 μM Compound: VX-680	SANGER: Inhibition of human KM-H2 cell growth in a cell viability assay. SANGER: Inhibition of human KM-H2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KMOE-2	IC₅₀	55.446 μM Compound: VX-680	SANGER: Inhibition of human KMOE-2 cell growth in a cell viability assay. SANGER: Inhibition of human KMOE-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KMS-12-PE	IC₅₀	285.426 μM Compound: VX-680	SANGER: Inhibition of human KMS-12-PE cell growth in a cell viability assay. SANGER: Inhibition of human KMS-12-PE cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KNS-42	IC₅₀	30.896 μM Compound: VX-680	SANGER: Inhibition of human KNS-42 cell growth in a cell viability assay. SANGER: Inhibition of human KNS-42 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KNS-81-FD	IC₅₀	34.546 μM Compound: VX-680	SANGER: Inhibition of human KNS-81-FD cell growth in a cell viability assay. SANGER: Inhibition of human KNS-81-FD cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KP-N-RT-BM-1	IC₅₀	25.475 μM Compound: VX-680	SANGER: Inhibition of human KP-N-RT-BM-1 cell growth in a cell viability assay. SANGER: Inhibition of human KP-N-RT-BM-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KP-N-YS	IC₅₀	0.544 μM Compound: VX-680	SANGER: Inhibition of human KP-N-YS cell growth in a cell viability assay. SANGER: Inhibition of human KP-N-YS cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KS-1	IC₅₀	0.238 μM Compound: VX-680	SANGER: Inhibition of human KS-1 cell growth in a cell viability assay. SANGER: Inhibition of human KS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KU812 cell line	IC₅₀	41.507 μM Compound: VX-680	SANGER: Inhibition of human KU812 cell growth in a cell viability assay. SANGER: Inhibition of human KU812 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KURAMOCHI	IC₅₀	1.789 μM Compound: VX-680	SANGER: Inhibition of human KURAMOCHI cell growth in a cell viability assay. SANGER: Inhibition of human KURAMOCHI cell growth in a cell viability assay.	10.6019/CHEMBL1201861
KY821	IC₅₀	9.775 μM Compound: VX-680	SANGER: Inhibition of human KY821 cell growth in a cell viability assay. SANGER: Inhibition of human KY821 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
L-363	IC₅₀	46.881 μM Compound: VX-680	SANGER: Inhibition of human L-363 cell growth in a cell viability assay. SANGER: Inhibition of human L-363 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
L-428	IC₅₀	388.804 μM Compound: VX-680	SANGER: Inhibition of human L-428 cell growth in a cell viability assay. SANGER: Inhibition of human L-428 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
L-540	IC₅₀	60.805 μM Compound: VX-680	SANGER: Inhibition of human L-540 cell growth in a cell viability assay. SANGER: Inhibition of human L-540 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LAMA-84	IC₅₀	0.352 μM Compound: VX-680	SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay. SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LAN-6	IC₅₀	126.554 μM Compound: VX-680	SANGER: Inhibition of human LAN-6 cell growth in a cell viability assay. SANGER: Inhibition of human LAN-6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB1047-RCC	IC₅₀	2.881 μM Compound: VX-680	SANGER: Inhibition of human LB1047-RCC cell growth in a cell viability assay. SANGER: Inhibition of human LB1047-RCC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB2241-RCC	IC₅₀	138.478 μM Compound: VX-680	SANGER: Inhibition of human LB2241-RCC cell growth in a cell viability assay. SANGER: Inhibition of human LB2241-RCC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB2518-MEL	IC₅₀	27.177 μM Compound: VX-680	SANGER: Inhibition of human LB2518-MEL cell growth in a cell viability assay. SANGER: Inhibition of human LB2518-MEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB373-MEL-D	IC₅₀	11.383 μM Compound: VX-680	SANGER: Inhibition of human LB373-MEL-D cell growth in a cell viability assay. SANGER: Inhibition of human LB373-MEL-D cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB647-SCLC	IC₅₀	0.215 μM Compound: VX-680	SANGER: Inhibition of human LB647-SCLC cell growth in a cell viability assay. SANGER: Inhibition of human LB647-SCLC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB771-HNC	IC₅₀	95.455 μM Compound: VX-680	SANGER: Inhibition of human LB771-HNC cell growth in a cell viability assay. SANGER: Inhibition of human LB771-HNC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB831-BLC	IC₅₀	25.153 μM Compound: VX-680	SANGER: Inhibition of human LB831-BLC cell growth in a cell viability assay. SANGER: Inhibition of human LB831-BLC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LB996-RCC	IC₅₀	31.17 μM Compound: VX-680	SANGER: Inhibition of human LB996-RCC cell growth in a cell viability assay. SANGER: Inhibition of human LB996-RCC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LC-1F	IC₅₀	160.979 μM Compound: VX-680	SANGER: Inhibition of human LC-1F cell growth in a cell viability assay. SANGER: Inhibition of human LC-1F cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LC-2-ad	IC₅₀	0.088 μM Compound: VX-680	SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay. SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LC4-1	IC₅₀	12.771 μM Compound: VX-680	SANGER: Inhibition of human LC4-1 cell growth in a cell viability assay. SANGER: Inhibition of human LC4-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LNCaP-Clone-FGC	IC₅₀	532.537 μM Compound: VX-680	SANGER: Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay. SANGER: Inhibition of human LNCaP-Clone-FGC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LOUCY	IC₅₀	3.187 μM Compound: VX-680	SANGER: Inhibition of human LOUCY cell growth in a cell viability assay. SANGER: Inhibition of human LOUCY cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LoVo	GI₅₀	45.3 μM Compound: VX-680	Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay	[PMID: 30502115]
LoVo	IC₅₀	13.6 μM Compound: VX-680	Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 32035750]
LoVo	IC₅₀	45.3 μM Compound: VX-680	Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay	[PMID: 30728112]
LOX IMVI	IC₅₀	143.123 μM Compound: VX-680	SANGER: Inhibition of human LOXIMVI cell growth in a cell viability assay. SANGER: Inhibition of human LOXIMVI cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LP-1	IC₅₀	21.343 μM Compound: VX-680	SANGER: Inhibition of human LP-1 cell growth in a cell viability assay. SANGER: Inhibition of human LP-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LS-1034	IC₅₀	6.757 μM Compound: VX-680	SANGER: Inhibition of human LS-1034 cell growth in a cell viability assay. SANGER: Inhibition of human LS-1034 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LS-123	IC₅₀	14.159 μM Compound: VX-680	SANGER: Inhibition of human LS-123 cell growth in a cell viability assay. SANGER: Inhibition of human LS-123 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LS-411N	IC₅₀	0.578 μM Compound: VX-680	SANGER: Inhibition of human LS-411N cell growth in a cell viability assay. SANGER: Inhibition of human LS-411N cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LS-513	IC₅₀	45.916 μM Compound: VX-680	SANGER: Inhibition of human LS-513 cell growth in a cell viability assay. SANGER: Inhibition of human LS-513 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LU-134-A	IC₅₀	2.893 μM Compound: VX-680	SANGER: Inhibition of human LU-134-A cell growth in a cell viability assay. SANGER: Inhibition of human LU-134-A cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LU-139	IC₅₀	4.618 μM Compound: VX-680	SANGER: Inhibition of human LU-139 cell growth in a cell viability assay. SANGER: Inhibition of human LU-139 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LU-165	IC₅₀	315.786 μM Compound: VX-680	SANGER: Inhibition of human LU-165 cell growth in a cell viability assay. SANGER: Inhibition of human LU-165 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Lu-65	IC₅₀	544.656 μM Compound: VX-680	SANGER: Inhibition of human LU-65 cell growth in a cell viability assay. SANGER: Inhibition of human LU-65 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
LXF-289 cell line	IC₅₀	0.404 μM Compound: VX-680	SANGER: Inhibition of human LXF-289 cell growth in a cell viability assay. SANGER: Inhibition of human LXF-289 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MC116	IC₅₀	0.85 μM Compound: VX-680	SANGER: Inhibition of human MC116 cell growth in a cell viability assay. SANGER: Inhibition of human MC116 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MC-CAR	IC₅₀	5.068 μM Compound: VX-680	SANGER: Inhibition of human MC-CAR cell growth in a cell viability assay. SANGER: Inhibition of human MC-CAR cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MCF7	IC₅₀	0.048 μM Compound: 39, VX-680	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 18630890]
MCF7	IC₅₀	0.38 μM Compound: VX-680	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22572580]
MCF7	IC₅₀	1.02 μM Compound: VX-680	Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 35476959]
MCF7	IC₅₀	1.3 μM Compound: VX-680	Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
MCF7	IC₅₀	1.3 μM Compound: VX-680, MK-0457	Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
MCF7	IC₅₀	17.39 μM Compound: VX-680	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31862411]
MCF7	IC₅₀	39.78 μM Compound: VX680	Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by MTT assay	[PMID: 32941989]
MDA-MB-134-VI	IC₅₀	113.284 μM Compound: VX-680	SANGER: Inhibition of human MDA-MB-134-VI cell growth in a cell viability assay. SANGER: Inhibition of human MDA-MB-134-VI cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MDA-MB-231	IC₅₀	0.127 μM Compound: VX-680	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
MDA-MB-231	IC₅₀	0.127 μM Compound: VX-680, MK-0457	Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
MEG-01	IC₅₀	0.278 μM Compound: VX-680	SANGER: Inhibition of human MEG-01 cell growth in a cell viability assay. SANGER: Inhibition of human MEG-01 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MFH-ino	IC₅₀	0.01 μM Compound: VX-680	SANGER: Inhibition of human MFH-ino cell growth in a cell viability assay. SANGER: Inhibition of human MFH-ino cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MFM-223	IC₅₀	326.314 μM Compound: VX-680	SANGER: Inhibition of human MFM-223 cell growth in a cell viability assay. SANGER: Inhibition of human MFM-223 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MHH-CALL-2	IC₅₀	393.197 μM Compound: VX-680	SANGER: Inhibition of human MHH-CALL-2 cell growth in a cell viability assay. SANGER: Inhibition of human MHH-CALL-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MHH-NB-11	IC₅₀	3.953 μM Compound: VX-680	SANGER: Inhibition of human MHH-NB-11 cell growth in a cell viability assay. SANGER: Inhibition of human MHH-NB-11 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MHH-PREB-1	IC₅₀	28.073 μM Compound: VX-680	SANGER: Inhibition of human MHH-PREB-1 cell growth in a cell viability assay. SANGER: Inhibition of human MHH-PREB-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MLMA	IC₅₀	82.009 μM Compound: VX-680	SANGER: Inhibition of human MLMA cell growth in a cell viability assay. SANGER: Inhibition of human MLMA cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MMAC-SF	IC₅₀	4.025 μM Compound: VX-680	SANGER: Inhibition of human MMAC-SF cell growth in a cell viability assay. SANGER: Inhibition of human MMAC-SF cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MN-60	IC₅₀	191.241 μM Compound: VX-680	SANGER: Inhibition of human MN-60 cell growth in a cell viability assay. SANGER: Inhibition of human MN-60 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Mo	IC₅₀	339.664 μM Compound: VX-680	SANGER: Inhibition of human Mo-T cell growth in a cell viability assay. SANGER: Inhibition of human Mo-T cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MOLT-16	IC₅₀	1.354 μM Compound: VX-680	SANGER: Inhibition of human MOLT-16 cell growth in a cell viability assay. SANGER: Inhibition of human MOLT-16 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MOLT-4	IC₅₀	0.0212 μM Compound: VX-680, MK-0457	Antiproliferative activity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
MOLT-4	IC₅₀	0.233 μM Compound: VX-680	SANGER: Inhibition of human MOLT-4 cell growth in a cell viability assay. SANGER: Inhibition of human MOLT-4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MONO-MAC-6	IC₅₀	0.079 μM Compound: VX-680	SANGER: Inhibition of human MONO-MAC-6 cell growth in a cell viability assay. SANGER: Inhibition of human MONO-MAC-6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MPP-89	IC₅₀	25.531 μM Compound: VX-680	SANGER: Inhibition of human MPP-89 cell growth in a cell viability assay. SANGER: Inhibition of human MPP-89 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MRK-nu-1	IC₅₀	0.381 μM Compound: VX-680	SANGER: Inhibition of human MRK-nu-1 cell growth in a cell viability assay. SANGER: Inhibition of human MRK-nu-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MS-1	IC₅₀	158.313 μM Compound: VX-680	SANGER: Inhibition of human MS-1 cell growth in a cell viability assay. SANGER: Inhibition of human MS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MSTO-211H	IC₅₀	336.798 μM Compound: VX-680	SANGER: Inhibition of human MSTO-211H cell growth in a cell viability assay. SANGER: Inhibition of human MSTO-211H cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MZ1-PC	IC₅₀	3.992 μM Compound: VX-680	SANGER: Inhibition of human MZ1-PC cell growth in a cell viability assay. SANGER: Inhibition of human MZ1-PC cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MZ2-MEL	IC₅₀	28.614 μM Compound: VX-680	SANGER: Inhibition of human MZ2-MEL cell growth in a cell viability assay. SANGER: Inhibition of human MZ2-MEL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
MZ7-mel	IC₅₀	14.443 μM Compound: VX-680	SANGER: Inhibition of human MZ7-mel cell growth in a cell viability assay. SANGER: Inhibition of human MZ7-mel cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NALM-6	IC₅₀	0.026 μM Compound: VX-680	SANGER: Inhibition of human NALM-6 cell growth in a cell viability assay. SANGER: Inhibition of human NALM-6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB1	IC₅₀	12.29 μM Compound: VX-680	SANGER: Inhibition of human NB1 cell growth in a cell viability assay. SANGER: Inhibition of human NB1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB10	IC₅₀	244.83 μM Compound: VX-680	SANGER: Inhibition of human NB10 cell growth in a cell viability assay. SANGER: Inhibition of human NB10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB13	IC₅₀	0.28 μM Compound: VX-680	SANGER: Inhibition of human NB13 cell growth in a cell viability assay. SANGER: Inhibition of human NB13 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB14	IC₅₀	215.389 μM Compound: VX-680	SANGER: Inhibition of human NB14 cell growth in a cell viability assay. SANGER: Inhibition of human NB14 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB17	IC₅₀	2.293 μM Compound: VX-680	SANGER: Inhibition of human NB17 cell growth in a cell viability assay. SANGER: Inhibition of human NB17 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB5	IC₅₀	1.642 μM Compound: VX-680	SANGER: Inhibition of human NB5 cell growth in a cell viability assay. SANGER: Inhibition of human NB5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB6	IC₅₀	0.773 μM Compound: VX-680	SANGER: Inhibition of human NB6 cell growth in a cell viability assay. SANGER: Inhibition of human NB6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB69	IC₅₀	11.77 μM Compound: VX-680	SANGER: Inhibition of human NB69 cell growth in a cell viability assay. SANGER: Inhibition of human NB69 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NB7	IC₅₀	211.002 μM Compound: VX-680	SANGER: Inhibition of human NB7 cell growth in a cell viability assay. SANGER: Inhibition of human NB7 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCCIT	IC₅₀	11.058 μM Compound: VX-680	SANGER: Inhibition of human NCCIT cell growth in a cell viability assay. SANGER: Inhibition of human NCCIT cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1092	IC₅₀	66.521 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1092 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1092 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1155	IC₅₀	37.815 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1155 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1155 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H128	IC₅₀	325.21 μM Compound: VX-680	SANGER: Inhibition of human NCI-H128 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H128 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1304	IC₅₀	1.831 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1304 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1304 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1355	IC₅₀	11.943 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1395	IC₅₀	239.3 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1395 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1395 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1417	IC₅₀	14.305 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1417 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1417 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1436	IC₅₀	7.699 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1436 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1436 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1522	IC₅₀	68.171 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1522 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1522 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1581	IC₅₀	6.784 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1581 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1581 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1648	IC₅₀	5.815 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1648 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1648 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1650	IC₅₀	94.805 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1650 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1650 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1694	IC₅₀	44.947 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1694 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1694 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1770	IC₅₀	8.903 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1770 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1770 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1838	IC₅₀	275.603 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1838 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1838 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H187	IC₅₀	0.641 μM Compound: VX-680	SANGER: Inhibition of human NCI-H187 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H187 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1882	IC₅₀	12.407 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1882 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1882 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H1963	IC₅₀	1.706 μM Compound: VX-680	SANGER: Inhibition of human NCI-H1963 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H1963 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2081	IC₅₀	53.989 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2081 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2081 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H209	IC₅₀	2.913 μM Compound: VX-680	SANGER: Inhibition of human NCI-H209 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H209 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2107	IC₅₀	2.837 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2107 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2107 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2126	IC₅₀	5.646 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2126 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2126 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2141	IC₅₀	55.563 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2141 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2141 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2171	IC₅₀	3.924 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2171 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2171 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H2196	IC₅₀	181.8 μM Compound: VX-680	SANGER: Inhibition of human NCI-H2196 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H2196 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H226	IC₅₀	110.169 μM Compound: VX-680	SANGER: Inhibition of human NCI-H226 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H226 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H23	IC₅₀	71.449 μM Compound: VX-680	SANGER: Inhibition of human NCI-H23 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H23 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H322M	IC₅₀	404.085 μM Compound: VX-680	SANGER: Inhibition of human NCI-H322M cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H322M cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H345	IC₅₀	48.468 μM Compound: VX-680	SANGER: Inhibition of human NCI-H345 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H345 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H446	IC₅₀	51.524 μM Compound: VX-680	SANGER: Inhibition of human NCI-H446 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H446 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H510A	IC₅₀	0.438 μM Compound: VX-680	SANGER: Inhibition of human NCI-H510A cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H510A cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H524	IC₅₀	0.511 μM Compound: VX-680	SANGER: Inhibition of human NCI-H524 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H524 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H526	IC₅₀	8.256 μM Compound: VX-680	SANGER: Inhibition of human NCI-H526 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H526 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H64	IC₅₀	288.067 μM Compound: VX-680	SANGER: Inhibition of human NCI-H64 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H64 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H69	IC₅₀	65.892 μM Compound: VX-680	SANGER: Inhibition of human NCI-H69 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H69 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H716	IC₅₀	370.996 μM Compound: VX-680	SANGER: Inhibition of human NCI-H716 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H716 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H719	IC₅₀	78.264 μM Compound: VX-680	SANGER: Inhibition of human NCI-H719 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H719 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H720	IC₅₀	2.062 μM Compound: VX-680	SANGER: Inhibition of human NCI-H720 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H720 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H747	IC₅₀	3.942 μM Compound: VX-680	SANGER: Inhibition of human NCI-H747 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H747 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H748	IC₅₀	25.763 μM Compound: VX-680	SANGER: Inhibition of human NCI-H748 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H748 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H82	IC₅₀	2.838 μM Compound: VX-680	SANGER: Inhibition of human NCI-H82 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H82 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-H889	IC₅₀	25.193 μM Compound: VX-680	SANGER: Inhibition of human NCI-H889 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-H889 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NCI-N87	IC₅₀	11.6 μM Compound: VX-680, MK-0457	Antiproliferative activity against human NCI-N87 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human NCI-N87 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
NEC8	IC₅₀	13.104 μM Compound: VX-680	SANGER: Inhibition of human NEC8 cell growth in a cell viability assay. SANGER: Inhibition of human NEC8 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NH-12	IC₅₀	403.265 μM Compound: VX-680	SANGER: Inhibition of human NH-12 cell growth in a cell viability assay. SANGER: Inhibition of human NH-12 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NKM-1	IC₅₀	1.028 μM Compound: VX-680	SANGER: Inhibition of human NKM-1 cell growth in a cell viability assay. SANGER: Inhibition of human NKM-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NMC-G1	IC₅₀	4.227 μM Compound: VX-680	SANGER: Inhibition of human NMC-G1 cell growth in a cell viability assay. SANGER: Inhibition of human NMC-G1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
no-10	IC₅₀	51.701 μM Compound: VX-680	SANGER: Inhibition of human no-10 cell growth in a cell viability assay. SANGER: Inhibition of human no-10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
no-11	IC₅₀	25.747 μM Compound: VX-680	SANGER: Inhibition of human no-11 cell growth in a cell viability assay. SANGER: Inhibition of human no-11 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NOMO-1	IC₅₀	3.023 μM Compound: VX-680	SANGER: Inhibition of human NOMO-1 cell growth in a cell viability assay. SANGER: Inhibition of human NOMO-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NOS-1	IC₅₀	3.848 μM Compound: VX-680	SANGER: Inhibition of human NOS-1 cell growth in a cell viability assay. SANGER: Inhibition of human NOS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
NTERA-2-cl-D1	IC₅₀	0.014 μM Compound: VX-680	SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay. SANGER: Inhibition of human NTERA-S-cl-D1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OCI-AML2	IC₅₀	0.644 μM Compound: VX-680	SANGER: Inhibition of human OCI-AML2 cell growth in a cell viability assay. SANGER: Inhibition of human OCI-AML2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OCUB-M	IC₅₀	0.17 μM Compound: VX-680	SANGER: Inhibition of human OCUB-M cell growth in a cell viability assay. SANGER: Inhibition of human OCUB-M cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OMC-1	IC₅₀	274.28 μM Compound: VX-680	SANGER: Inhibition of human OMC-1 cell growth in a cell viability assay. SANGER: Inhibition of human OMC-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ONS-76	IC₅₀	0.665 μM Compound: VX-680	SANGER: Inhibition of human ONS-76 cell growth in a cell viability assay. SANGER: Inhibition of human ONS-76 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OPM-2	IC₅₀	12.16 μM Compound: VX-680	SANGER: Inhibition of human OPM-2 cell growth in a cell viability assay. SANGER: Inhibition of human OPM-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OS-RC-2	IC₅₀	5.986 μM Compound: VX-680	SANGER: Inhibition of human OS-RC-2 cell growth in a cell viability assay. SANGER: Inhibition of human OS-RC-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
OVCAR-4	IC₅₀	2.461 μM Compound: VX-680	SANGER: Inhibition of human OVCAR-4 cell growth in a cell viability assay. SANGER: Inhibition of human OVCAR-4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
P30-OHK	IC₅₀	323.028 μM Compound: VX-680	SANGER: Inhibition of human P30-OHK cell growth in a cell viability assay. SANGER: Inhibition of human P30-OHK cell growth in a cell viability assay.	10.6019/CHEMBL1201861
P31-FUJ	IC₅₀	481.069 μM Compound: VX-680	SANGER: Inhibition of human P31-FUJ cell growth in a cell viability assay. SANGER: Inhibition of human P31-FUJ cell growth in a cell viability assay.	10.6019/CHEMBL1201861
PANC-1	IC₅₀	4.13 μM Compound: VX-680, MK-0457	Antiproliferative activity against human PANC1 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human PANC1 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
PC-3	IC₅₀	5.81 μM Compound: VX-680, MK-0457	Antiproliferative activity against human PC3 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human PC3 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
PF-382	IC₅₀	3.358 μM Compound: VX-680	SANGER: Inhibition of human PF-382 cell growth in a cell viability assay. SANGER: Inhibition of human PF-382 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
PSN1	IC₅₀	0.22 μM Compound: VX-680	SANGER: Inhibition of human PSN1 cell growth in a cell viability assay. SANGER: Inhibition of human PSN1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
QIMR-WIL	IC₅₀	0.427 μM Compound: VX-680	SANGER: Inhibition of human QIMR-WIL cell growth in a cell viability assay. SANGER: Inhibition of human QIMR-WIL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Raji	IC₅₀	30.559 μM Compound: VX-680	SANGER: Inhibition of human Raji cell growth in a cell viability assay. SANGER: Inhibition of human Raji cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Ramos-2G6-4C10	IC₅₀	64.236 μM Compound: VX-680	SANGER: Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay. SANGER: Inhibition of human Ramos-2G6-4C10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RCC10RGB	IC₅₀	92.94 μM Compound: VX-680	SANGER: Inhibition of human RCC10RGB cell growth in a cell viability assay. SANGER: Inhibition of human RCC10RGB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
REH	IC₅₀	25.467 μM Compound: VX-680	SANGER: Inhibition of human REH cell growth in a cell viability assay. SANGER: Inhibition of human REH cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RH-1	IC₅₀	3.173 μM Compound: VX-680	SANGER: Inhibition of human RH-1 cell growth in a cell viability assay. SANGER: Inhibition of human RH-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RKO	IC₅₀	0.308 μM Compound: VX-680	SANGER: Inhibition of human RKO cell growth in a cell viability assay. SANGER: Inhibition of human RKO cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RL	IC₅₀	448.463 μM Compound: VX-680	SANGER: Inhibition of human RL cell growth in a cell viability assay. SANGER: Inhibition of human RL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RL95-2	IC₅₀	0.406 μM Compound: VX-680	SANGER: Inhibition of human RL95-2 cell growth in a cell viability assay. SANGER: Inhibition of human RL95-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RPMI-6666	IC₅₀	2.162 μM Compound: VX-680	SANGER: Inhibition of human RPMI-6666 cell growth in a cell viability assay. SANGER: Inhibition of human RPMI-6666 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RPMI-8226	IC₅₀	71.624 μM Compound: VX-680	SANGER: Inhibition of human RPMI-8226 cell growth in a cell viability assay. SANGER: Inhibition of human RPMI-8226 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RPMI-8866	IC₅₀	468.649 μM Compound: VX-680	SANGER: Inhibition of human RPMI-8866 cell growth in a cell viability assay. SANGER: Inhibition of human RPMI-8866 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RS4-11	IC₅₀	0.004 μM Compound: VX-680	SANGER: Inhibition of human RS4-11 cell growth in a cell viability assay. SANGER: Inhibition of human RS4-11 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
RXF 393	IC₅₀	32.497 μM Compound: VX-680	SANGER: Inhibition of human RXF393 cell growth in a cell viability assay. SANGER: Inhibition of human RXF393 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SBC-1	IC₅₀	1.125 μM Compound: VX-680	SANGER: Inhibition of human SBC-1 cell growth in a cell viability assay. SANGER: Inhibition of human SBC-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SCC-15	IC₅₀	366.065 μM Compound: VX-680	SANGER: Inhibition of human SCC-15 cell growth in a cell viability assay. SANGER: Inhibition of human SCC-15 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SCC-3	IC₅₀	77.581 μM Compound: VX-680	SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay. SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SCH	IC₅₀	229.958 μM Compound: VX-680	SANGER: Inhibition of human SCH cell growth in a cell viability assay. SANGER: Inhibition of human SCH cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SCLC-21H	IC₅₀	1.971 μM Compound: VX-680	SANGER: Inhibition of human SCLC-21H cell growth in a cell viability assay. SANGER: Inhibition of human SCLC-21H cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SF-126	IC₅₀	0.948 μM Compound: VX-680	SANGER: Inhibition of human SF126 cell growth in a cell viability assay. SANGER: Inhibition of human SF126 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SF-268	IC₅₀	4.799 μM Compound: VX-680	SANGER: Inhibition of human SF268 cell growth in a cell viability assay. SANGER: Inhibition of human SF268 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SF-539	IC₅₀	17.992 μM Compound: VX-680	SANGER: Inhibition of human SF539 cell growth in a cell viability assay. SANGER: Inhibition of human SF539 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Sf9	IC₅₀	0.023 μM Compound: Tozasertib	Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate	[PMID: 30234987]
Sf9	IC₅₀	20 nM Compound: 1, VX-680	Inhibition of GST-tagged Aurora kinase A catalytic domain (123 to 401 amino acids) (unknown origin) expressed in sf9 cells using tetra(LRRWSLG) as substrate preincubated for 15 mins prior to substrate addition measured after 90 mins by luminescence assay Inhibition of GST-tagged Aurora kinase A catalytic domain (123 to 401 amino acids) (unknown origin) expressed in sf9 cells using tetra(LRRWSLG) as substrate preincubated for 15 mins prior to substrate addition measured after 90 mins by luminescence assay	[PMID: 23808327]
SH-4	IC₅₀	2.325 μM Compound: VX-680	SANGER: Inhibition of human SH-4 cell growth in a cell viability assay. SANGER: Inhibition of human SH-4 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SIG-M5	IC₅₀	0.167 μM Compound: VX-680	SANGER: Inhibition of human SIG-M5 cell growth in a cell viability assay. SANGER: Inhibition of human SIG-M5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SIMA	IC₅₀	526.427 μM Compound: VX-680	SANGER: Inhibition of human SIMA cell growth in a cell viability assay. SANGER: Inhibition of human SIMA cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SJSA-1	IC₅₀	11.289 μM Compound: VX-680	SANGER: Inhibition of human SJSA-1 cell growth in a cell viability assay. SANGER: Inhibition of human SJSA-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-BR-3	IC₅₀	9.99 μM Compound: VX-680, MK-0457	Antiproliferative activity against human SKBR3 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human SKBR3 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
SK-LMS-1	IC₅₀	1.222 μM Compound: VX-680	SANGER: Inhibition of human SK-LMS-1 cell growth in a cell viability assay. SANGER: Inhibition of human SK-LMS-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SKM-1	IC₅₀	53.069 μM Compound: VX-680	SANGER: Inhibition of human SKM-1 cell growth in a cell viability assay. SANGER: Inhibition of human SKM-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-MEL-1	IC₅₀	112.779 μM Compound: VX-680	SANGER: Inhibition of human SK-MEL-1 cell growth in a cell viability assay. SANGER: Inhibition of human SK-MEL-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-MEL-2	IC₅₀	245.248 μM Compound: VX-680	SANGER: Inhibition of human SK-MEL-2 cell growth in a cell viability assay. SANGER: Inhibition of human SK-MEL-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-MM-2	IC₅₀	19.555 μM Compound: VX-680	SANGER: Inhibition of human SK-MM-2 cell growth in a cell viability assay. SANGER: Inhibition of human SK-MM-2 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-N-DZ	IC₅₀	0.962 μM Compound: VX-680	SANGER: Inhibition of human SK-N-DZ cell growth in a cell viability assay. SANGER: Inhibition of human SK-N-DZ cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-NEP-1	IC₅₀	1.211 μM Compound: VX-680	SANGER: Inhibition of human SK-NEP-1 cell growth in a cell viability assay. SANGER: Inhibition of human SK-NEP-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-N-FI	IC₅₀	2.869 μM Compound: VX-680	SANGER: Inhibition of human SK-N-FI cell growth in a cell viability assay. SANGER: Inhibition of human SK-N-FI cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-PN-DW	IC₅₀	0.791 μM Compound: VX-680	SANGER: Inhibition of human SK-PN-DW cell growth in a cell viability assay. SANGER: Inhibition of human SK-PN-DW cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SK-UT-1	IC₅₀	0.16 μM Compound: VX-680	SANGER: Inhibition of human SK-UT-1 cell growth in a cell viability assay. SANGER: Inhibition of human SK-UT-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNB-75	IC₅₀	10.076 μM Compound: VX-680	SANGER: Inhibition of human SNB75 cell growth in a cell viability assay. SANGER: Inhibition of human SNB75 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNU1	IC₅₀	214.379 μM Compound: VX-680	SANGER: Inhibition of human NCI-SNU-1 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-SNU-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNU-16	IC₅₀	0.636 μM Compound: VX-680	SANGER: Inhibition of human NCI-SNU-16 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-SNU-16 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNU-5	IC₅₀	83.603 μM Compound: VX-680	SANGER: Inhibition of human NCI-SNU-5 cell growth in a cell viability assay. SANGER: Inhibition of human NCI-SNU-5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNU-C1	IC₅₀	28.943 μM Compound: VX-680	SANGER: Inhibition of human SNU-C1 cell growth in a cell viability assay. SANGER: Inhibition of human SNU-C1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SNU-C2B	IC₅₀	38.165 μM Compound: VX-680	SANGER: Inhibition of human SNU-C2B cell growth in a cell viability assay. SANGER: Inhibition of human SNU-C2B cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SR	IC₅₀	0.246 μM Compound: VX-680	SANGER: Inhibition of human SR cell growth in a cell viability assay. SANGER: Inhibition of human SR cell growth in a cell viability assay.	10.6019/CHEMBL1201861
ST486	IC₅₀	0.231 μM Compound: VX-680	SANGER: Inhibition of human ST486 cell growth in a cell viability assay. SANGER: Inhibition of human ST486 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SU-DHL-1	IC₅₀	231.383 μM Compound: VX-680	SANGER: Inhibition of human SU-DHL-1 cell growth in a cell viability assay. SANGER: Inhibition of human SU-DHL-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SUP-T1	IC₅₀	444.151 μM Compound: VX-680	SANGER: Inhibition of human SUP-T1 cell growth in a cell viability assay. SANGER: Inhibition of human SUP-T1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SW 954	IC₅₀	0.122 μM Compound: VX-680	SANGER: Inhibition of human SW954 cell growth in a cell viability assay. SANGER: Inhibition of human SW954 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SW 962	IC₅₀	30.275 μM Compound: VX-680	SANGER: Inhibition of human SW962 cell growth in a cell viability assay. SANGER: Inhibition of human SW962 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SW684	IC₅₀	179.373 μM Compound: VX-680	SANGER: Inhibition of human SW684 cell growth in a cell viability assay. SANGER: Inhibition of human SW684 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SW872	IC₅₀	4.343 μM Compound: VX-680	SANGER: Inhibition of human SW872 cell growth in a cell viability assay. SANGER: Inhibition of human SW872 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
SW982	IC₅₀	0.214 μM Compound: VX-680	SANGER: Inhibition of human SW982 cell growth in a cell viability assay. SANGER: Inhibition of human SW982 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TALL-1	IC₅₀	11.406 μM Compound: VX-680	SANGER: Inhibition of human TALL-1 cell growth in a cell viability assay. SANGER: Inhibition of human TALL-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-1	IC₅₀	5.49 μM Compound: VX-680	SANGER: Inhibition of human TE-1 cell growth in a cell viability assay. SANGER: Inhibition of human TE-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-10	IC₅₀	1.129 μM Compound: VX-680	SANGER: Inhibition of human TE-10 cell growth in a cell viability assay. SANGER: Inhibition of human TE-10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-11	IC₅₀	0.15 μM Compound: VX-680	SANGER: Inhibition of human TE-11 cell growth in a cell viability assay. SANGER: Inhibition of human TE-11 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-12	IC₅₀	4.564 μM Compound: VX-680	SANGER: Inhibition of human TE-12 cell growth in a cell viability assay. SANGER: Inhibition of human TE-12 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-15	IC₅₀	0.851 μM Compound: VX-680	SANGER: Inhibition of human TE-15 cell growth in a cell viability assay. SANGER: Inhibition of human TE-15 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-441-T	IC₅₀	34.637 μM Compound: VX-680	SANGER: Inhibition of human TE-441-T cell growth in a cell viability assay. SANGER: Inhibition of human TE-441-T cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-5	IC₅₀	49.712 μM Compound: VX-680	SANGER: Inhibition of human TE-5 cell growth in a cell viability assay. SANGER: Inhibition of human TE-5 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-6	IC₅₀	48.446 μM Compound: VX-680	SANGER: Inhibition of human TE-6 cell growth in a cell viability assay. SANGER: Inhibition of human TE-6 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-8	IC₅₀	1.804 μM Compound: VX-680	SANGER: Inhibition of human TE-8 cell growth in a cell viability assay. SANGER: Inhibition of human TE-8 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TE-9	IC₅₀	3.267 μM Compound: VX-680	SANGER: Inhibition of human TE-9 cell growth in a cell viability assay. SANGER: Inhibition of human TE-9 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TGBC1TKB	IC₅₀	27.558 μM Compound: VX-680	SANGER: Inhibition of human TGBC1TKB cell growth in a cell viability assay. SANGER: Inhibition of human TGBC1TKB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TGBC24TKB	IC₅₀	0.864 μM Compound: VX-680	SANGER: Inhibition of human TGBC24TKB cell growth in a cell viability assay. SANGER: Inhibition of human TGBC24TKB cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TGW	IC₅₀	2.658 μM Compound: VX-680	SANGER: Inhibition of human TGW cell growth in a cell viability assay. SANGER: Inhibition of human TGW cell growth in a cell viability assay.	10.6019/CHEMBL1201861
THP-1	IC₅₀	510.276 μM Compound: VX-680	SANGER: Inhibition of human THP-1 cell growth in a cell viability assay. SANGER: Inhibition of human THP-1 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TK-10	IC₅₀	5.355 μM Compound: VX-680	SANGER: Inhibition of human TK10 cell growth in a cell viability assay. SANGER: Inhibition of human TK10 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
TUR	IC₅₀	431.377 μM Compound: VX-680	SANGER: Inhibition of human TUR cell growth in a cell viability assay. SANGER: Inhibition of human TUR cell growth in a cell viability assay.	10.6019/CHEMBL1201861
U-266	IC₅₀	28.637 μM Compound: VX-680	SANGER: Inhibition of human U-266 cell growth in a cell viability assay. SANGER: Inhibition of human U-266 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
U-698-M	IC₅₀	278.633 μM Compound: VX-680	SANGER: Inhibition of human U-698-M cell growth in a cell viability assay. SANGER: Inhibition of human U-698-M cell growth in a cell viability assay.	10.6019/CHEMBL1201861
U-87MG ATCC	IC₅₀	14.5 μM Compound: VX-680	Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 32035750]
U-87MG ATCC	IC₅₀	58.212 μM Compound: VX-680	SANGER: Inhibition of human U-87-MG cell growth in a cell viability assay. SANGER: Inhibition of human U-87-MG cell growth in a cell viability assay.	10.6019/CHEMBL1201861
U-937	IC₅₀	0.036 μM Compound: VX-680	Antiproliferative activity against human U937 cells after 48 hrs by CCK8 assay Antiproliferative activity against human U937 cells after 48 hrs by CCK8 assay	[PMID: 29358147]
U-937	IC₅₀	0.036 μM Compound: VX-680, MK-0457	Antiproliferative activity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay Antiproliferative activity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay	[PMID: 24681066]
UACC-257	IC₅₀	7.045 μM Compound: VX-680	SANGER: Inhibition of human UACC-257 cell growth in a cell viability assay. SANGER: Inhibition of human UACC-257 cell growth in a cell viability assay.	10.6019/CHEMBL1201861
VA-ES-BJ	IC₅₀	0.201 μM Compound: VX-680	SANGER: Inhibition of human VA-ES-BJ cell growth in a cell viability assay. SANGER: Inhibition of human VA-ES-BJ cell growth in a cell viability assay.	10.6019/CHEMBL1201861
Vero C1008	IC₅₀	>2.0 × 10⁵M Compound: COVC-3361686327	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	10.6019/CHEMBL4651402
WSU-NHL	IC₅₀	511.692 μM Compound: VX-680	SANGER: Inhibition of human WSU-NHL cell growth in a cell viability assay. SANGER: Inhibition of human WSU-NHL cell growth in a cell viability assay.	10.6019/CHEMBL1201861
YT	IC₅₀	74.914 μM Compound: VX-680	SANGER: Inhibition of human YT cell growth in a cell viability assay. SANGER: Inhibition of human YT cell growth in a cell viability assay.	10.6019/CHEMBL1201861

Molecular Weight

464.59

Formula

C₂₃H₂₈N₈OS

CAS No.

639089-54-6

SMILES

O=C(C1CC1)NC2=CC=C(C=C2)SC3=NC(N4CCN(CC4)C)=CC(NC5=NNC(C)=C5)=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xia B, et al. Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking. Biomed J. 2021 Dec;44(6 Suppl 1):S15-S24. [Content Brief]

DDR1-IN-11 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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DDR1-IN-11639089-54-6Discoidin Domain ReceptorInhibitorinhibitorinhibit

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DDR1-IN-11

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DDR1-IN-11 Related Classifications

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The molarity calculator equation

The dilution calculator equation

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