DDR1 - discoidin domain receptor tyrosine kinase 1 Gene

Also Known as CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 780

About DDR1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,880,970-30,900,156 (from NCBI)

This gene has 58 transcripts (splice variants), 1 gene allele, 196 orthologues and 53 paralogues. Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues.

Summary

Receptor Tyrosine Kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of Collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

DDR1 Products (59)

mRNA	Protein	Name
NM_001387911.1	NP_001374840.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_011514884.2	XP_011513186.1	epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387916.1	NP_001374845.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001297653.2	NP_001284582.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_013994.3	NP_054700.2	epithelial discoidin domain-containing receptor 1 isoform 3 precursor
XM_017011268.3	XP_016866757.1	epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387912.1	NP_001374841.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387900.1	NP_001374829.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419318.1	XP_047275274.1	epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419327.1	XP_047275283.1	epithelial discoidin domain-containing receptor 1 isoform X5
XM_024446541.2	XP_024302309.1	epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419324.1	XP_047275280.1	epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419330.1	XP_047275286.1	epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419332.1	XP_047275288.1	epithelial discoidin domain-containing receptor 1 isoform X4
NM_001387909.1	NP_001374838.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387892.1	NP_001374821.1	epithelial discoidin domain-containing receptor 1 isoform 3 precursor
NM_001202523.3	NP_001189452.2	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_047419323.1	XP_047275279.1	epithelial discoidin domain-containing receptor 1 isoform X1
NM_013993.3	NP_054699.2	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387901.1	NP_001374830.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001202521.1	NP_001189450.1	epithelial discoidin domain-containing receptor 1 isoform 4 precursor
NM_001387904.1	NP_001374833.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419331.1	XP_047275287.1	epithelial discoidin domain-containing receptor 1 isoform X3
XM_047419326.1	XP_047275282.1	epithelial discoidin domain-containing receptor 1 isoform X2
XM_047419333.1	XP_047275289.1	epithelial discoidin domain-containing receptor 1 isoform X4
XM_047419322.1	XP_047275278.1	epithelial discoidin domain-containing receptor 1 isoform X1
NM_001387913.1	NP_001374842.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387915.1	NP_001374844.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387894.1	NP_001374823.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001297654.2	NP_001284583.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419328.1	XP_047275284.1	epithelial discoidin domain-containing receptor 1 isoform X5
NM_001954.5	NP_001945.3	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387906.1	NP_001374835.1	epithelial discoidin domain-containing receptor 1 isoform 7 precursor
NM_001297652.2	NP_001284581.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387918.1	NP_001374847.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387897.1	NP_001374826.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001202522.1	NP_001189451.1	epithelial discoidin domain-containing receptor 1 isoform 5 precursor
NM_001387893.1	NP_001374822.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387910.1	NP_001374839.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387902.1	NP_001374831.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419329.1	XP_047275285.1	epithelial discoidin domain-containing receptor 1 isoform X5
XM_047419319.1	XP_047275275.1	epithelial discoidin domain-containing receptor 1 isoform X1
NM_001387899.1	NP_001374828.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419320.1	XP_047275276.1	epithelial discoidin domain-containing receptor 1 isoform X1
XM_047419334.1	XP_047275290.1	epithelial discoidin domain-containing receptor 1 isoform X4
NM_001387898.1	NP_001374827.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419325.1	XP_047275281.1	epithelial discoidin domain-containing receptor 1 isoform X2
NM_001387895.1	NP_001374824.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387914.1	NP_001374843.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387908.1	NP_001374837.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
XM_024446540.2	XP_024302308.1	epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387903.1	NP_001374832.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
XM_047419321.1	XP_047275277.1	epithelial discoidin domain-containing receptor 1 isoform X1
NM_001410869.1	NP_001397798.1	epithelial discoidin domain-containing receptor 1 isoform 6 precursor
XM_011514887.3	XP_011513189.1	epithelial discoidin domain-containing receptor 1 isoform X5
NM_001387896.1	NP_001374825.1	epithelial discoidin domain-containing receptor 1 isoform 2 precursor
NM_001387917.1	NP_001374846.1	epithelial discoidin domain-containing receptor 1 isoform 1 precursor
NM_001387905.1	NP_001374834.1	epithelial discoidin domain-containing receptor 1 isoform 7 precursor
NM_001387907.1	NP_001374836.1	epithelial discoidin domain-containing receptor 1 isoform 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	9659899	GOA
enables collagen binding	IMP IMP: Inferred from mutant phenotype	12065315	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16337946	GOA
enables protein tyrosine kinase collagen receptor activity	IDA IDA: Inferred from direct assay	9659899	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	9659899	GOA
involved in collagen-activated tyrosine kinase receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12065315	GOA
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	21044884	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9659899	GOA
involved in regulation of extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	12065315	GOA
involved in smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	12065315	GOA
involved in smooth muscle cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12065315	GOA
involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	12065315	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDR1 Protein Structure

F5_F8_type_C

Pkinase_Tyr

0
200
400
600
800
913 a.a.

Protein Preferred Names	Protein Names
epithelial discoidin domain-containing receptor 1	CD167 antigen-like family member A PTK3A protein tyrosine kinase 3A cell adhesion kinase mammary carcinoma kinase 10 neuroepithelial tyrosine kinase neurotrophic tyrosine kinase, receptor, type 4 protein-tyrosine kinase RTK-6 tyrosine kinase DDR tyrosine-protein kinase CAK

DDR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDR1	Q08345	DDR2	Homo sapiens	Q16832	Anti Tag CoIP	33961781
Intra	DDR1	Q08345	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	16337946
Intra	DDR1	Q08345	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	16337946
Intra	DDR1	Q08345	NCK2	Homo sapiens	O43639	Anti Tag CoIP	16337946
Intra	DDR1	Q08345	NCK2	Homo sapiens	O43639	Pull Down	16337946

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DDR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75304	DDR1 Protein, Human (Active, sf9, His-GST)	Q08345-1 (R444-V913)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P75305	DDR1 Protein, Human (HEK293, His)	Q08345-1 (D21-A417)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

DDR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85119	DDR1 Antibody (YA4811)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Cervix Small Cell Carcinoma	Small Cell Carcinoma Of The Cervix Small Cell Carcinoma Of The Cervix Uteri
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type	Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome Smed-Sl Smed-Sl/Ac Smed Short Limb-Abnormal Calcification Type Smed Short Limb-Hand Type Spondylometaepiphyseal Dysplasia Short Limb-Hand Type Smed, Type Ii Smed Type 2 Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type Smed, Short Limb-Hand Type Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type Smed, Short Limb-Abnormal Calcification Type Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type SEMD-SL Smed Type Ii Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Mast-Cell Leukemia	Mast Cell Leukemia Leukemia, Mast-Cell Leukemia Mast Cell Mast Cell Leukaemia Nos Mast Cell Leukaemia Without Mention Of Remission
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Pulmonary Fibrosis	Fibrosis Of Lung

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16961	Sitravatinib	Inhibitor	99.57%	Phase 3
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135401	VU6015929	Inhibitor	99.50%	Unkown
HY-114173	DDR1-IN-4	Inhibitor	98.19%	Unkown
HY-NP175	Collagen (bovine skin)	Ligand	/	Unkown
HY-133670	DDR1-IN-6	Inhibitor	98.02%	Unkown
HY-156552	DDR1/2 inhibitor-2	Inhibitor	99.73%	Unkown
HY-13979A	DDR1-IN-1 dihydrochloride	Inhibitor	98.92%	Unkown
HY-133669	DDR1-IN-5	Inhibitor	99.65%	Unkown
HY-167208	SR-302	Inhibitor	98.51%	Unkown
HY-176184	PROTAC DDR1 degrader-1	Degrader	98.69%	Unkown
HY-183068	AP4-43	Inhibitor	99.76%	Unkown
HY-16961A	Sitravatinib malate	Inhibitor	/	Unkown
HY-187094	7rh-C2-O-Boc	Ligand	/	Unkown
HY-175281	SJ11646	Degrader	/	Unkown
HY-187093	7rh-Boc	Ligand	/	Unkown
HY-173284	DDR1-IN-11	Inhibitor	/	Unkown
HY-181839	DDR1/2 IN-4	Inhibitor	/	Unkown
HY-179535	Axl-IN-21	Inhibitor	/	Unkown
HY-176185	DDR1 ligand 1		/	Unkown
HY-122848	DDR1/2 inhibitor-3	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDR1	RGD	RGD:2252
Macaca mulatta	DDR1	VGNC	VGNC:81058
Mus musculus	DDR1	MGD	MGI:99216
Bos taurus	DDR1	VGNC	VGNC:53966
Felis catus	DDR1	VGNC	VGNC:102411
Canis familiaris	DDR1	VGNC	VGNC:57221
Others	DDR1	NCBI