2. Gene
  3. NCK2 - NCK adaptor protein 2 Gene

NCK2 - NCK adaptor protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRB4; NCKbeta

Gene ID: 8440 | Gene type: protein coding

About NCK2

Cytogenetic location: 2q12.2 Genomic coordinates (GRCh38): 2:105,744,453-105,894,272 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 9 paralogues. Ubiquitous expression in duodenum (RPKM 14.7), spleen (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor Protein Tyrosine Kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

NCK2 Products(3)

mRNA Protein Name
NM_001004720.3 NP_001004720.1 cytoplasmic protein NCK2 isoform A
NM_001004722.4 NP_001004722.1 cytoplasmic protein NCK2 isoform B
NM_003581.5 NP_003572.2 cytoplasmic protein NCK2 isoform A

NCK2 Protein Structure

SH3_1

SH3_1: SH3 domain (8 - 53)

SH3_9

SH3_9: Variant SH3 domain (118 - 165)

SH3_1

SH3_1: SH3 domain (203 - 248)

SH2

SH2: SH2 domain (285 - 359)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
Protein Preferred Names Protein Names

cytoplasmic protein NCK2

SH2/SH3 adaptor protein NCK-beta

Related Diseases

Diseases Alias
Frank-Ter Haar Syndrome

Ter Haar Syndrome

Borrone Dermatocardioskeletal Syndrome

FTHS

Autosomal Recessive Melnick-Needles Syndrome

Borrone Di Rocco Crovato Syndrome

Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay

Melnick-Needles Syndrome, Autosomal Recessive, Formerly

Frank Ter Haar Syndrome
Juvenile Glaucoma

Glaucoma Of Childhood

Hydrophthalmos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0710 alpha-Cyperone 99.80% Unkown
HY-RS09081 NCK2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCK2 RGD RGD:1305965
Macaca mulatta NCK2 VGNC VGNC:75142
Felis catus NCK2 VGNC VGNC:68428
Canis familiaris NCK2 VGNC VGNC:43652
Bos taurus NCK2 VGNC VGNC:31914
Mus musculus NCK2 MGD MGI:1306821