2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. CX-5279

CX-5279 is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia.

For research use only. We do not sell to patients.

CX-5279

CX-5279 Chemical Structure

CAS No. : 1333382-32-3

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CX-5279 Related Antibodies

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Description

CX-5279 is an efficient and selective CK2 inhibitor with IC50 values for nCK2 and CK2α of 2.73 and 0.91 nM, respectively. CX-5279 is sensitive to mutations at Val66, Ile174, and V66I174AA, with IC50 values of 13.8, 12.5, and 23.35 nM, respectively. CX-5279's inhibitory activity against PIM1 is very weak, with a IC50 value of 8.52 μM. CX-5279 exhibits anti-proliferative activity in various cancer cell lines. CX-5279 can be used for research on cancers such as pancreatic cancer and leukemia[1].

IC50 & Target[1]

CK2α

0.91 nM (IC50)

Molecular Weight

461.37

Formula

C22H15F3N5NaO2
CAS No.
SMILES

O=C(C1=CC2=NC(NC3=CC=CC(C(F)(F)F)=C3)=C4N=C(NC5CC5)N=CC4=C2C=C1)O[Na]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CX-5279 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CX-52791333382-32-3CX5279CX 5279Casein KinaseProtein Kinase CK2CX-4945CX-5011ATP-competitive inhibitorCrystal structureSelectivityGini coefficientInhibitor potencyCancer therapy.Inhibitorinhibitorinhibit

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