PIM1
null PIM1 is a constitutively active serine/threonine kinase whose abundance is controlled mainly by transcription and protein turnover rather than by activation-loop phosphorylation. Induced downstream of JAK-STAT signaling by cytokines such as IL-3 and FLT3 ligand, it supports hematopoietic cell survival and proliferation by phosphorylating BAD, 4E-BP1 and other substrates, and it stabilizes MYC protein. PIM1 was originally identified as a proviral integration site that collaborates with MYC in murine lymphomagenesis, and it is overexpressed in AML, prostate and pancreatic cancers. Broad-spectrum PIM inhibitors have entered clinical trials for hematologic malignancies and solid tumors.
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PIM1 組換えタンパク質 (1)
- 生物種:
- 由来:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 分子式: Human
- 分子量: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
