BCAR1 - BCAR1 scaffold protein, Cas family member Gene

Also Known as CAS; CAS1; CASS1; CRKAS; P130Cas

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9564

About BCAR1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,228,181-75,268,007 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 201 orthologues and 3 paralogues. Broad expression in spleen (RPKM 6.5), kidney (RPKM 6.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, Apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and Cancer. [provided by RefSeq, Sep 2017]

BCAR1 Products (9)

mRNA	Protein	Name
NM_001170714.3	NP_001164185.1	breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001170715.3	NP_001164186.1	breast cancer anti-estrogen resistance protein 1 isoform 2
NM_001170716.3	NP_001164187.1	breast cancer anti-estrogen resistance protein 1 isoform 3
NM_001170717.3	NP_001164188.1	breast cancer anti-estrogen resistance protein 1 isoform 4
NM_001170718.3	NP_001164189.1	breast cancer anti-estrogen resistance protein 1 isoform 5
NM_001170719.3	NP_001164190.1	breast cancer anti-estrogen resistance protein 1 isoform 7
NM_001170720.3	NP_001164191.1	breast cancer anti-estrogen resistance protein 1 isoform 8
NM_001170721.3	NP_001164192.1	breast cancer anti-estrogen resistance protein 1 isoform 9
NM_014567.5	NP_055382.2	breast cancer anti-estrogen resistance protein 1 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9285683	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8070403	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9020138	GOA
involved in actin filament organization	IDA IDA: Inferred from direct assay	16105984	GOA
involved in antigen receptor-mediated signaling pathway	IDA IDA: Inferred from direct assay	10587647	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	9425168	GOA
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in endothelin receptor signaling pathway	IDA IDA: Inferred from direct assay	19086031	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	8649368	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	9472046	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21245381	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8070403	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	21245381	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	21245381	GOA
located in ruffle	IDA IDA: Inferred from direct assay	9472046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAR1 Protein Structure

SH3_1

Serine_rich

DUF3513

0
200
400
600
800
870 a.a.

Protein Preferred Names	Protein Names
breast cancer anti-estrogen resistance protein 1	BCAR1, Cas family scaffold protein

BCAR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BCAR1	P56945	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	BCAR1	P56945	EEIG1	Homo sapiens	Q5T9C2-3	Validated Y2H	32296183
Intra	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	Pull Down	19732724
Intra	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	IF	19732724
Intra	BCAR1	P56945	INPPL1	Homo sapiens	O15357	Anti Bait CoIP	11158326
Intra	BCAR1	P56945	SRCIN1	Homo sapiens	Q9C0H9	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	ITC	22081014
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	GMS	22081014
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	Anti Bait CoIP	22081014
Intra	BCAR1	P56945	PTPN12	Homo sapiens	Q05209	Affinity Chrom	9285683
Intra	BCAR1	P56945	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32296183
Intra	BCAR1	P56945	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	28007913
Intra	BCAR1	P56945	FYN	Homo sapiens	P06241	Pull Down	9360983
Intra	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Pull Down	17038317
Intra	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Anti Bait CoIP	17038317
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	Pull Down	17038317
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	CoIP	21034468
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	Fluorescence	10542110
Intra	BCAR1	P56945	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	BCAR1	P56945	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	BCAR1	P56945	SH2D3C	Homo sapiens	Q8N5H7	Anti Tag CoIP	33961781
Cross	BCAR1	P56945	Srcin1	Mus musculus	Q9QWI6	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	CRK	Homo sapiens	P46108	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	CRK	Homo sapiens	P46108	Pull Down	17038317
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Anti Bait CoIP	9407132
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Filter Binding	9418872
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Phosphatase Assay	10889023
Intra	BCAR1	P56945	MMP14	Homo sapiens	P50281	Anti Bait CoIP	18164686

Cross: Cross-species interaction Intra: Intraspecies interaction

BCAR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810579	Phospho-BCAR1 (Tyr410) Antibody (YA9843)	WB	Human
HY-P82815	BCAR1 Antibody (YA2560)	WB	Human, Mouse, Rat
HY-P82815A	BCAR1 Antibody (YA2560)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Estrogen Resistance	Estrogen Resistance Syndrome ESTRR Estrogen Insensitivity
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Nephronophthisis 1	NPHP1 Nephronophthisis, Familial Juvenile Nph1 Nephronophthisis 1, Juvenile Juvenile Nephronophthisis 1 Familial Juvenile Nephronophthisis 1 Nephronophthisis, Type 1
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01397	BCAR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BCAR1	VGNC	VGNC:38398
Felis catus	BCAR1	VGNC	VGNC:69188
Mus musculus	BCAR1	MGD	MGI:108091
Macaca mulatta	BCAR1	VGNC	VGNC:70234
Rattus norvegicus	BCAR1	RGD	RGD:2406
Bos taurus	BCAR1	VGNC	VGNC:26437
Others	BCAR1	NCBI