2. Gene
  3. BCAR1 - BCAR1 scaffold protein, Cas family member Gene

BCAR1 - BCAR1 scaffold protein, Cas family member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAS; CAS1; CASS1; CRKAS; P130Cas

Gene ID: 9564 | Gene type: protein coding

About BCAR1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,228,181-75,268,007 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 201 orthologues and 3 paralogues. Broad expression in spleen (RPKM 6.5), kidney (RPKM 6.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, Apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and Cancer. [provided by RefSeq, Sep 2017]

BCAR1 Products(9)

mRNA Protein Name
NM_001170714.3 NP_001164185.1 breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001170715.3 NP_001164186.1 breast cancer anti-estrogen resistance protein 1 isoform 2
NM_001170716.3 NP_001164187.1 breast cancer anti-estrogen resistance protein 1 isoform 3
NM_001170717.3 NP_001164188.1 breast cancer anti-estrogen resistance protein 1 isoform 4
NM_001170718.3 NP_001164189.1 breast cancer anti-estrogen resistance protein 1 isoform 5
NM_001170719.3 NP_001164190.1 breast cancer anti-estrogen resistance protein 1 isoform 7
NM_001170720.3 NP_001164191.1 breast cancer anti-estrogen resistance protein 1 isoform 8
NM_001170721.3 NP_001164192.1 breast cancer anti-estrogen resistance protein 1 isoform 9
NM_014567.5 NP_055382.2 breast cancer anti-estrogen resistance protein 1 isoform 6

BCAR1 Protein Structure

SH3_1

SH3_1: SH3 domain (9 - 56)

Serine_rich

Serine_rich: Serine rich protein interaction domain (454 - 609)

DUF3513

DUF3513: Domain of unknown function (DUF3513) (650 - 864)

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  • 870 a.a.
Protein Preferred Names Protein Names

breast cancer anti-estrogen resistance protein 1

BCAR1, Cas family scaffold protein

Related Diseases

Diseases Alias
Estrogen Resistance

Estrogen Resistance Syndrome

ESTRR

Estrogen Insensitivity
Cystic Kidney Disease

Renal Cyst

Simple Renal Cyst

Kidney Cysts

Kidney Diseases, Cystic

Renal Cysts

Kidney Cyst

Cystic Kidney

Congenital Cystic Kidney Disease

Cystic Kidney Diseases

Bosniak 1 Cyst
Nephronophthisis 1

NPHP1

Nephronophthisis, Familial Juvenile

Nph1

Nephronophthisis 1, Juvenile

Juvenile Nephronophthisis 1

Familial Juvenile Nephronophthisis 1

Nephronophthisis, Type 1
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01397 BCAR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris BCAR1 VGNC VGNC:38398
Felis catus BCAR1 VGNC VGNC:69188
Mus musculus BCAR1 MGD MGI:108091
Macaca mulatta BCAR1 VGNC VGNC:70234
Rattus norvegicus BCAR1 RGD RGD:2406
Bos taurus BCAR1 VGNC VGNC:26437