FYN - FYN proto-oncogene, Src family tyrosine kinase Gene
Also Known as SLK; SYN; p59-FYN
Species: Homo sapiens
About FYN
This gene has 29 transcripts (splice variants), 265 orthologues and 32 paralogues. Broad expression in brain (RPKM 36.8), lymph node (RPKM 29.8) and 23 other tissues.
Summary
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
FYN Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001370529.1 | NP_001357458.1 | tyrosine-protein kinase Fyn isoform a |
| NM_002037.5 | NP_002028.1 | tyrosine-protein kinase Fyn isoform a |
| NM_153047.4 | NP_694592.1 | tyrosine-protein kinase Fyn isoform b |
| NM_153048.4 | NP_694593.1 | tyrosine-protein kinase Fyn isoform c |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables G protein-coupled receptor binding |
IPI
IPI: Inferred from physical interaction
|
23169819 | GOA |
| enables disordered domain specific binding |
IPI
IPI: Inferred from physical interaction
|
9351809 | GOA |
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
27525436 | GOA |
| enables ephrin receptor binding |
IPI
IPI: Inferred from physical interaction
|
10498895 | GOA |
| enables growth factor receptor binding |
IPI
IPI: Inferred from physical interaction
|
16479011 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
14993658 | GOA |
| enables non-membrane spanning protein tyrosine kinase activity |
IDA
IDA: Inferred from direct assay
|
11606584 | GOA |
| enables phospholipase activator activity |
IDA
IDA: Inferred from direct assay
|
11606584 | GOA |
| enables phospholipase binding |
IPI
IPI: Inferred from physical interaction
|
11606584 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
1661130 | GOA |
| enables protein tyrosine kinase activity |
EXP
EXP: Inferred from Experiment
|
1381360 | GOA |
| enables protein tyrosine kinase activity |
IDA
IDA: Inferred from direct assay
|
15713798 | GOA |
| enables protein tyrosine kinase activity |
IMP
IMP: Inferred from mutant phenotype
|
16979591 | GOA |
| enables scaffold protein binding |
IPI
IPI: Inferred from physical interaction
|
23555801 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in G protein-coupled glutamate receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
24012003 | GOA |
| involved in T cell receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
7722293 | GOA |
| involved in cellular response to amyloid-beta |
IMP
IMP: Inferred from mutant phenotype
|
27520374 | GOA |
| involved in heart process |
IGI
IGI: Inferred from genetic interaction
|
27525436 | GOA |
| involved in intracellular signal transduction |
IDA
IDA: Inferred from direct assay
|
11606584 | GOA |
| involved in natural killer cell activation |
IDA
IDA: Inferred from direct assay
|
15713798 | GOA |
| involved in peptidyl-tyrosine phosphorylation |
IMP
IMP: Inferred from mutant phenotype
|
11606584 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in dendrite |
IDA
IDA: Inferred from direct assay
|
24012003 | GOA |
| located in endosome |
IDA
IDA: Inferred from direct assay
|
15611048 | GOA |
| colocalizes with membrane raft |
IDA
IDA: Inferred from direct assay
|
12150984 | GOA |
| is active in membrane raft |
IDA
IDA: Inferred from direct assay
|
12218089 | GOA |
| located in membrane raft |
IMP
IMP: Inferred from mutant phenotype
|
23386614 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
12150984 | GOA |
FYN Protein Structure
SH3_1: SH3 domain (88 - 135)
SH2: SH2 domain (149 - 231)
Pkinase_Tyr: Protein tyrosine kinase (269 - 517)
- 0
- 100
- 200
- 300
- 400
- 500
- 534 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tyrosine-protein kinase Fyn |
|
FYN Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FYN | P06241 | ABL2 | Homo sapiens | P42684 | 17474147 | |
|
Cross
|
FYN | P06241 | Slamf7 | Mus musculus | Q8BHK6 | 19151721 | |
|
Intra
|
FYN | P06241 | HTR6 | Homo sapiens | P50406 | 17189269 | |
|
Intra
|
FYN | P06241 | HTR6 | Homo sapiens | P50406 | 17189269 | |
|
Intra
|
FYN | P06241 | HTR6 | Homo sapiens | P50406 | 17189269 | |
|
Intra
|
FYN | P06241 | ARHGAP33 | Homo sapiens | O14559 | 16777849 | |
|
Intra
|
FYN | P06241 | KHDRBS1 | Homo sapiens | Q07666 | 9045636 | |
|
Intra
|
FYN | P06241 | KHDRBS1 | Homo sapiens | Q07666 | 9045636 | |
|
Intra
|
FYN | P06241 | KHDRBS1 | Homo sapiens | Q07666 | 31980649 | |
|
Intra
|
FYN | P06241 | KHDRBS1 | Homo sapiens | Q07666 | 7516469 | |
|
Intra
|
FYN | P06241 | KHDRBS1 | Homo sapiens | Q07666 | 31413325 | |
|
Intra
|
FYN | P06241 | GP6 | Homo sapiens | Q9HCN6-1 | 19940238 | |
|
Intra
|
FYN | P06241 | GP6 | Homo sapiens | Q9HCN6-1 | 19940238 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 25814554 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 10409671 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 17474147 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 9207119 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 9207119 | |
|
Intra
|
FYN | P06241 | FYB1 | Homo sapiens | O15117 | 25814554 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-5 | 25156556 | |
|
Intra
|
FYN | P06241 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
FYN | P06241 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Intra
|
FYN | P06241 | APBB2 | Homo sapiens | Q92870-2 | 32814053 | |
|
Cross
|
FYN | P06241 | q2ghu2_ehrcr | Ehrlichia chaffeensis | Q2GHU2 | 19273555 | |
|
Intra
|
FYN | P06241 | PAG1 | Homo sapiens | Q9NWQ8 | 18056706 | |
|
Intra
|
FYN | P06241 | PAG1 | Homo sapiens | Q9NWQ8 | 23866081 | |
|
Intra
|
FYN | P06241 | PAG1 | Homo sapiens | Q9NWQ8 | 18056706 | |
|
Intra
|
FYN | P06241 | CDC37 | Homo sapiens | Q16543 | 31980649 | |
|
Intra
|
FYN | P06241 | CDC37 | Homo sapiens | Q16543 | 32707033 | |
|
Intra
|
FYN | P06241 | CDC37 | Homo sapiens | Q16543 | 33961781 | |
|
Intra
|
FYN | P06241 | HSP90AA1 | Homo sapiens | P07900 | 33961781 | |
|
Intra
|
FYN | P06241 | HSP90AA1 | Homo sapiens | P07900 | 31980649 | |
|
Intra
|
FYN | P06241 | HSP90AA1 | Homo sapiens | P07900 | 32707033 | |
|
Intra
|
FYN | P06241 | CD2AP | Homo sapiens | Q9Y5K6 | 17474147 | |
|
Intra
|
FYN | P06241 | PTK2B | Homo sapiens | Q14289 | 10867021 | |
|
Intra
|
FYN | P06241 | PTK2B | Homo sapiens | Q14289 | 31413325 | |
|
Intra
|
FYN | P06241 | ARHGAP32 | Homo sapiens | A7KAX9 | 12788081 | |
|
Intra
|
FYN | P06241 | ARHGAP32 | Homo sapiens | A7KAX9 | 12788081 | |
|
Intra
|
FYN | P06241 | ARHGAP32 | Homo sapiens | A7KAX9 | 12788081 | |
|
Intra
|
FYN | P06241 | PDCD6IP | Homo sapiens | Q8WUM4 | 22641034 | |
|
Intra
|
FYN | P06241 | PDCD6IP | Homo sapiens | Q8WUM4 | 22641034 | |
|
Intra
|
FYN | P06241 | PDCD6IP | Homo sapiens | Q8WUM4 | 22641034 | |
|
Intra
|
FYN | P06241 | PDCD6IP | Homo sapiens | Q8WUM4 | 22641034 | |
|
Intra
|
FYN | P06241 | ASAP1 | Homo sapiens | Q9ULH1 | 17474147 | |
|
Intra
|
FYN | P06241 | NELFB | Homo sapiens | Q8WX92 | 17474147 | |
|
Intra
|
FYN | P06241 | HSP90AB1 | Homo sapiens | P08238 | 22939624 | |
|
Intra
|
FYN | P06241 | HSP90AB1 | Homo sapiens | P08238 | 31980649 | |
|
Intra
|
FYN | P06241 | HSP90AB1 | Homo sapiens | P08238 | 32707033 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636 | 25156556 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-8 | 25156556 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-8 | 25156556 | |
|
Intra
|
FYN | P06241 | PRKCQ | Homo sapiens | Q04759 | 10383400 | |
|
Intra
|
FYN | P06241 | PRKCQ | Homo sapiens | Q04759 | 10383400 | |
|
Intra
|
FYN | P06241 | PRKCQ | Homo sapiens | Q04759 | 10383400 | |
|
Intra
|
FYN | P06241 | FASLG | Homo sapiens | P48023 | 19807924 | |
|
Intra
|
FYN | P06241 | MED28 | Homo sapiens | Q9H204 | 16964398 | |
|
Intra
|
FYN | P06241 | MED28 | Homo sapiens | Q9H204 | 16899217 | |
|
Intra
|
FYN | P06241 | MED28 | Homo sapiens | Q9H204 | 16899217 | |
|
Intra
|
FYN | P06241 | CBL | Homo sapiens | P22681 | 7642581 | |
|
Intra
|
FYN | P06241 | CBL | Homo sapiens | P22681 | 7642581 | |
|
Intra
|
FYN | P06241 | CBL | Homo sapiens | P22681 | 8621719 | |
|
Intra
|
FYN | P06241 | CBL | Homo sapiens | P22681 | 15556646 | |
|
Intra
|
FYN | P06241 | SRC | Homo sapiens | P12931 | 33961781 | |
|
Intra
|
FYN | P06241 | SRC | Homo sapiens | P12931 | 16966330 | |
|
Intra
|
FYN | P06241 | SRC | Homo sapiens | P12931 | 31980649 | |
|
Intra
|
FYN | P06241 | ERBB2 | Homo sapiens | P04626 | 24815698 | |
|
Intra
|
FYN | P06241 | PDGFRB | Homo sapiens | P09619 | 7687537 | |
|
Intra
|
FYN | P06241 | PDGFRB | Homo sapiens | P09619 | 1661130 | |
|
Intra
|
FYN | P06241 | BCAR1 | Homo sapiens | P56945 | 17474147 | |
|
Intra
|
FYN | P06241 | BCAR1 | Homo sapiens | P56945 | 31413325 | |
|
Intra
|
FYN | P06241 | BCAR1 | Homo sapiens | P56945 | 9360983 | |
|
Intra
|
FYN | P06241 | PTK2 | Homo sapiens | Q05397 | 31413325 | |
|
Intra
|
FYN | P06241 | PRKCD | Homo sapiens | Q05655 | 25241761 | |
|
Intra
|
FYN | P06241 | PRKCD | Homo sapiens | Q05655 | 12721299 | |
|
Intra
|
FYN | P06241 | PNP | Homo sapiens | P00491 | 32814053 | |
|
Intra
|
FYN | P06241 | PNP | Homo sapiens | P00491 | 32814053 | |
|
Intra
|
FYN | P06241 | PNP | Homo sapiens | P00491 | 32814053 | |
|
Intra
|
FYN | P06241 | FN1 | Homo sapiens | P02751-7 | 17130124 | |
|
Intra
|
FYN | P06241 | FN1 | Homo sapiens | P02751-7 | 17130124 | |
|
Intra
|
FYN | P06241 | WBP11 | Homo sapiens | Q9Y2W2 | 25416956 | |
|
Intra
|
FYN | P06241 | EFS | Homo sapiens | O43281 | 31515488 | |
|
Intra
|
FYN | P06241 | NCKIPSD | Homo sapiens | Q9NZQ3 | 25416956 | |
|
Intra
|
FYN | P06241 | ADAM15 | Homo sapiens | Q13444 | 16374509 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-2 | 25156556 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-2 | 16115884 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-6 | 16115884 | |
|
Intra
|
FYN | P06241 | MAPT | Homo sapiens | P10636-6 | 25156556 | |
|
Intra
|
FYN | P06241 | CBX1 | Homo sapiens | P83916 | 32814053 | |
|
Intra
|
FYN | P06241 | CBX1 | Homo sapiens | P83916 | 32814053 | |
|
Intra
|
FYN | P06241 | CBX1 | Homo sapiens | P83916 | 32814053 | |
|
Intra
|
FYN | P06241 | ATXN1 | Homo sapiens | P54253 | 32814053 | |
|
Intra
|
FYN | P06241 | ATXN1 | Homo sapiens | P54253 | 32814053 | |
|
Intra
|
FYN | P06241 | ATXN1 | Homo sapiens | P54253 | 32814053 | |
|
Intra
|
FYN | P06241 | ATXN1 | Homo sapiens | P54253 | 16713569 | |
|
Intra
|
FYN | P06241 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Intra
|
FYN | P06241 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Intra
|
FYN | P06241 | SNCA | Homo sapiens | P37840 | 32814053 | |
|
Cross
|
FYN | P06241 | polg_hcv77 | Hepatitis C virus | P27958 | 15784897 | |
|
Cross
|
FYN | P06241 | polg_hcv77 | Hepatitis C virus | P27958 | 14993658 | |
|
Cross
|
FYN | P06241 | polg_hcv77 | Hepatitis C virus | P27958 | 15784897 | |
|
Cross
|
FYN | P06241 | polg_hcvco | Hepatitis C virus | Q9WMX2 | 15784897 | |
|
Cross
|
FYN | P06241 | Grm5 | Rattus norvegicus | P31424-2 | 24012003 | |
|
Cross
|
FYN | P06241 | Grm5 | Rattus norvegicus | P31424-2 | 24012003 |
FYN Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80681 | Fyn Antibody | WB | Human, Mouse, Rat |
| HY-P85176 | Fyn Antibody (YA4868) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P85545 | Fyn Antibody (YA5237) | WB, ICC/IF | Human, Monkey, Rat, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hepatitis E |
|
|
| Prion Disease |
|
|
| Wiskott-Aldrich Syndrome |
|
|
| Cd45 Deficiency |
|
|
| Platelet Glycoprotein Iv Deficiency |
|
|
| Alcohol Dependence |
|
|
| Combined Immunodeficiency |
|
|
| Congenital Generalized Lipodystrophy |
|
|
| Fragile X Syndrome |
|
|
| Focal Segmental Glomerulosclerosis |
|
|
| Severe Combined Immunodeficiency |
|
|
| Pick Disease Of Brain |
|
|
| Schizophrenia |
|
|
| Thrombocytopenia |
|
|
| Co-Trimoxazole Allergy |
|
|
| Asthma |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Colorectal Cancer |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Supranuclear Palsy, Progressive, 1 |
|
|
| Systemic Lupus Erythematosus |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | FYN | VGNC | VGNC:29163 |
| Macaca mulatta | FYN | VGNC | VGNC:72832 |
| Felis catus | FYN | VGNC | VGNC:62400 |
| Rattus norvegicus | FYN | RGD | RGD:2641 |
| Canis familiaris | FYN | VGNC | VGNC:41027 |
| Mus musculus | FYN | MGD | MGI:95602 |
| Others | FYN | NCBI |