FYN - FYN proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as SLK; SYN; p59-FYN

Gene ID: 2534 | Gene type: protein coding

About FYN

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:111,660,332-111,873,452 (from NCBI)

This gene has 29 transcripts (splice variants), 265 orthologues and 32 paralogues. Broad expression in brain (RPKM 36.8), lymph node (RPKM 29.8) and 23 other tissues.

Summary

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

FYN Products(4)

mRNA	Protein	Name
NM_001370529.1	NP_001357458.1	tyrosine-protein kinase Fyn isoform a
NM_002037.5	NP_002028.1	tyrosine-protein kinase Fyn isoform a
NM_153047.4	NP_694592.1	tyrosine-protein kinase Fyn isoform b
NM_153048.4	NP_694593.1	tyrosine-protein kinase Fyn isoform c

FYN Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
534 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Fyn

FYN oncogene related to SRC, FGR, YES

Related Diseases

Diseases

Alias

Hepatitis E

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Cd45 Deficiency

Platelet Glycoprotein Iv Deficiency

Platelet-Type Bleeding Disorder 10	Bdplt10
Cd36 Deficiency	Bleeding Disorder, Platelet-Type, 10
PG4D	Bleeding Disorder Platelet-Type 10
Deficiency, Platelet Glycoprotein Iv

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Progressive Supranuclear Ophthalmoplegia
Psp	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10234	Saracatinib		99.92%	Phase 3
HY-10186	TG 100801	Inhibitor	98.60%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-12624	Narazaciclib	Inhibitor	99.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13805	PP2	Inhibitor	99.35%	Unkown
HY-13804	PP1		99.00%	Unkown
HY-B0789	SU6656	Inhibitor	98.05%	Unkown
HY-13942	1-NM-PP1	Inhibitor	99.28%	Unkown
HY-13941	1-Naphthyl PP1	Inhibitor	99.08%	Unkown
HY-11011	A-770041	Inhibitor	99.95%	Unkown
HY-P3279	EPQpYEEIPIYL	Activator	98.94%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-13941B	1-Naphthyl PP1 hydrochloride	Inhibitor	99.94%	Unkown
HY-14340	WAY-181187	Agonist	98.07%	Unkown
HY-144290	ARN25068	Inhibitor	99.66%	Unkown
HY-103110	ST1936	Agonist	99.70%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-10234A	Saracatinib difumarate	Inhibitor	99.24%	Yes
HY-103110A	ST1936 oxalate	Agonist	/	Unkown
HY-110366	WAY-181187 oxalate	Agonist	/	Unkown
HY-155587	Hydroxy-PP		99.66%	Unkown
HY-RS05174	FYN Human Pre-designed siRNA Set A		/	Unkown
HY-W746031	WAY-181187 hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FYN	VGNC	VGNC:29163
Macaca mulatta	FYN	VGNC	VGNC:72832
Felis catus	FYN	VGNC	VGNC:62400
Rattus norvegicus	FYN	RGD	RGD:2641
Canis familiaris	FYN	VGNC	VGNC:41027
Mus musculus	FYN	MGD	MGI:95602
Others	FYN	NCBI

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