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  3. ABL2 - ABL proto-oncogene 2, non-receptor tyrosine kinase Gene

ABL2 - ABL proto-oncogene 2, non-receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARG; ABLL

Gene ID: 27 | Gene type: protein coding

About ABL2

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:179,099,330-179,229,677 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues, 32 paralogues and is associated with 85 phenotypes. Ubiquitous expression in gall bladder (RPKM 5.8), appendix (RPKM 2.3) and 25 other tissues.

Summary

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

ABL2 Products(8)

mRNA Protein Name
NM_001136000.3 NP_001129472.1 tyrosine-protein kinase ABL2 isoform d
NM_001136001.2 NP_001129473.1 tyrosine-protein kinase ABL2 isoform e
NM_001168236.2 NP_001161708.1 tyrosine-protein kinase ABL2 isoform f
NM_001168237.2 NP_001161709.1 tyrosine-protein kinase ABL2 isoform g
NM_001168238.2 NP_001161710.1 tyrosine-protein kinase ABL2 isoform h
NM_001168239.2 NP_001161711.1 tyrosine-protein kinase ABL2 isoform i
NM_005158.5 NP_005149.4 tyrosine-protein kinase ABL2 isoform c
NM_007314.4 NP_009298.1 tyrosine-protein kinase ABL2 isoform b

ABL2 Protein Structure

SH3_1

SH3_1: SH3 domain (113 - 159)

SH2

SH2: SH2 domain (173 - 248)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (288 - 538)

F_actin_bind

F_actin_bind: F-actin binding (1080 - 1182)

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  • 1182 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ABL2

Abelson tyrosine-protein kinase 2

Related Diseases

Diseases Alias
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

B-All With Bcr-Abl1

B-Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1

B Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148794 Risvodetinib Inhibitor 99.21% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS00105 ABL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ABL2 VGNC VGNC:69586
Rattus norvegicus ABL2 RGD RGD:1590898
Bos taurus ABL2 VGNC VGNC:50227
Mus musculus ABL2 MGD MGI:87860
Canis familiaris ABL2 VGNC VGNC:53323
Felis catus ABL2 VGNC VGNC:68440
Others ABL2 NCBI