PIK3R1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

Also Known as p85; AGM7; GRB1; IMD36; p85alpha; p85-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5295

About PIK3R1

Cytogenetic location: 5q13.1 Genomic coordinates (GRCh38): 5:68,215,756-68,301,821 (from NCBI)

This gene has 33 transcripts (splice variants), 248 orthologues, 2 paralogues and is associated with 135 phenotypes. Ubiquitous expression in fat (RPKM 16.6), brain (RPKM 16.6) and 24 other tissues.

Summary

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of Insulin, and a mutation in this gene has been associated with Insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

PIK3R1 Products (4)

mRNA	Protein	Name
NM_001242466.2	NP_001229395.1	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 4
NM_181504.4	NP_852556.2	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2
NM_181523.3	NP_852664.1	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
NM_181524.2	NP_852665.1	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 3

PIK3R1 Protein Structure

SH3_2

RhoGAP

SH2

0
200
400
600
724 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase regulatory subunit alpha	PI3 kinase-associated p85

PIK3R1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PIK3R1	P27986	CHAF1A	Homo sapiens	Q13111	Peptide Array	17474147
Intra	PIK3R1	P27986	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	26496610
Intra	PIK3R1	P27986	FLT1	Homo sapiens	P17948	Y2H	7657594
Intra	PIK3R1	P27986	FLT1	Homo sapiens	P17948	PLA	23397142
Intra	PIK3R1	P27986	FGFR1	Homo sapiens	P11362	PLA	25241761
Intra	PIK3R1	P27986	FGFR1	Homo sapiens	P11362	Pull Down	18412956
Intra	PIK3R1	P27986	CTLA4	Homo sapiens	P16410	CoIP	7807015
Intra	PIK3R1	P27986	CTLA4	Homo sapiens	P16410	CoIP	9813138
Intra	PIK3R1	P27986	MET	Homo sapiens	P08581	FPS	24728074
Intra	PIK3R1	P27986	IRS2	Homo sapiens	Q9Y4H2	Anti Bait CoIP	21241768
Intra	PIK3R1	P27986	IRS2	Homo sapiens	Q9Y4H2	Anti Tag CoIP	26496610
Intra	PIK3R1	P27986	SIK2	Homo sapiens	Q9H0K1	Protein Kinase Assay	27478041
Intra	PIK3R1	P27986	LAT	Homo sapiens	O43561	CoIP	10811803
Intra	PIK3R1	P27986	LAT	Homo sapiens	O43561	Pull Down	10811803
Intra	PIK3R1	P27986	KIT	Homo sapiens	P10721	CoIP	7537096
Intra	PIK3R1	P27986	KIT	Homo sapiens	P10721	FPS	24728074
Intra	PIK3R1	P27986	KIT	Homo sapiens	P10721	CoIP	1382595
Cross	PIK3R1	P27986	mt_povm1	Mus musculus polyomavirus	P0DOJ9	NMR	11123912
Intra	PIK3R1	P27986	ELK3	Homo sapiens	P41970	MAPPIT	25416956
Intra	PIK3R1	P27986	ELK3	Homo sapiens	P41970	Peptide Array	17474147
Intra	PIK3R1	P27986	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	21241768
Intra	PIK3R1	P27986	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	26496610
Intra	PIK3R1	P27986	PIK3CB	Homo sapiens	P42338	PLA	25241761
Intra	PIK3R1	P27986	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	35271311
Intra	PIK3R1	P27986	PIK3CB	Homo sapiens	P42338	Anti Tag CoIP	20713702
Intra	PIK3R1	P27986	AXL	Homo sapiens	P30530	Far-WB	9178760
Intra	PIK3R1	P27986	MAPK8	Homo sapiens	P45983	Anti Bait CoIP	25284480
Intra	PIK3R1	P27986	MAPK8	Homo sapiens	P45983	Anti Bait CoIP	16982329
Intra	PIK3R1	P27986	MAPK8	Homo sapiens	P45983	Anti Tag CoIP	25284480
Intra	PIK3R1	P27986	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	PIK3R1	P27986	EGFR	Homo sapiens	P00533	Competition Binding	7797556
Intra	PIK3R1	P27986	LAPTM4B	Homo sapiens	Q86VI4-3	Pull Down	20711237
Intra	PIK3R1	P27986	LAPTM4B	Homo sapiens	Q86VI4-3	Anti Tag CoIP	20711237
Intra	PIK3R1	P27986	PIK3R2	Homo sapiens	O00459	Anti Tag CoIP	35271311
Intra	PIK3R1	P27986	FLT3	Homo sapiens	P36888	Anti Bait CoIP	16982329
Intra	PIK3R1	P27986	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	PIK3R1	P27986	GRB2	Homo sapiens	P62993	Anti Bait CoIP	7642581
Intra	PIK3R1	P27986	CD28	Homo sapiens	P10747	Competition Binding	8146197
Intra	PIK3R1	P27986	CD28	Homo sapiens	P10747	CoIP	7568038
Intra	PIK3R1	P27986	CD28	Homo sapiens	P10747	Pull Down	10820259
Intra	PIK3R1	P27986	CD28	Homo sapiens	P10747	CoIP	7807015
Intra	PIK3R1	P27986	CD28	Homo sapiens	P10747	CoIP	10820259
Intra	PIK3R1	P27986	HTT	Homo sapiens	P42858	Y2H Prey Pooling	23275563
Intra	PIK3R1	P27986	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PIK3R1	P27986	INSR	Homo sapiens	P06213	Pull Down	9593725
Intra	PIK3R1	P27986	INSR	Homo sapiens	P06213	Pull Down	11796522
Intra	PIK3R1	P27986	IGF1R	Homo sapiens	P08069	CoIP	7589433
Intra	PIK3R1	P27986	IGF1R	Homo sapiens	P08069	Y2H	8603569
Intra	PIK3R1	P27986	IGF1R	Homo sapiens	P08069	PLA	25241761
Intra	PIK3R1	P27986	FASLG	Homo sapiens	P48023	Phage Display	19807924
Intra	PIK3R1	P27986	FASLG	Homo sapiens	P48023	PLA	25241761
Intra	PIK3R1	P27986	IRS1	Homo sapiens	P35568	Y2H	14632132
Intra	PIK3R1	P27986	GAB1	Homo sapiens	Q13480	CoIP	10978177
Intra	PIK3R1	P27986	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	PIK3R1	P27986	GAB1	Homo sapiens	Q13480	Pull Down	10978177
Intra	PIK3R1	P27986	CBL	Homo sapiens	P22681	Anti Bait CoIP	15581361
Intra	PIK3R1	P27986	CBL	Homo sapiens	P22681	CoIP	8662998
Intra	PIK3R1	P27986	CBL	Homo sapiens	P22681	Anti Bait CoIP	16982329
Intra	PIK3R1	P27986	CBL	Homo sapiens	P22681	Far-WB	15556646
Intra	PIK3R1	P27986	CBL	Homo sapiens	P22681	Experimental Interac	15556646
Intra	PIK3R1	P27986	TIRAP	Homo sapiens	P58753	Anti Tag CoIP	19574958
Intra	PIK3R1	P27986	AR	Homo sapiens	P10275	FPS	24728074
Intra	PIK3R1	P27986	TLR3	Homo sapiens	O15455	Anti Bait CoIP	16858407
Intra	PIK3R1	P27986	TLR3	Homo sapiens	O15455	Anti Tag CoIP	16858407
Intra	PIK3R1	P27986	SRC	Homo sapiens	P12931	PLA	23397142
Intra	PIK3R1	P27986	SRC	Homo sapiens	P12931	PLA	25241761
Intra	PIK3R1	P27986	SSTR2	Homo sapiens	P30874	Anti Bait CoIP	16917505
Intra	PIK3R1	P27986	SSTR2	Homo sapiens	P30874	SPR	16917505
Intra	PIK3R1	P27986	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	Pull Down	7692233
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	Y2H	11710529
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	ITC	10752619
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	CoIP	1314164
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	CoIP	11896612
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	NMR	8670861
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	Crosslink	7680644
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	SPR	7536927
Intra	PIK3R1	P27986	PDGFRB	Homo sapiens	P09619	Pull Down	8564419
Intra	PIK3R1	P27986	LTK	Homo sapiens	P29376	CoIP	9223670
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	Anti Tag CoIP	31031754
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	Anti Tag CoIP	35271311
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	Protein Kinase Assay	21827948
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	H1-H2 MS	21827948
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	Pull Down	21827948
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	Confocal	22020336
Intra	PIK3R1	P27986	PIK3CD	Homo sapiens	O00329	GMS	21827948
Intra	PIK3R1	P27986	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	PIK3R1	P27986	ERBB3	Homo sapiens	P21860	Anti Bait CoIP	10572067
Cross	PIK3R1	P27986	Nyap1	Mus musculus	Q6PFX7	Pull Down	21946561
Cross	PIK3R1	P27986	Nyap1	Mus musculus	Q6PFX7	Anti Tag CoIP	21946561
Cross	PIK3R1	P27986	Nyap2	Mus musculus	Q8BM65-4	Pull Down	21946561
Cross	PIK3R1	P27986	Nyap2	Mus musculus	Q8BM65-4	Anti Tag CoIP	21946561
Intra	PIK3R1	P27986	CMIP	Homo sapiens	Q8IY22	Anti Bait CoIP	20018188
Intra	PIK3R1	P27986	CMIP	Homo sapiens	Q8IY22	Anti Tag CoIP	20018188
Intra	PIK3R1	P27986	RXRA	Homo sapiens	P19793	Anti Bait CoIP	20541701
Intra	PIK3R1	P27986	RXRA	Homo sapiens	P19793	Anti Tag CoIP	20541701
Intra	PIK3R1	P27986	GRB10	Homo sapiens	Q13322	Anti Bait CoIP	23246379
Cross	PIK3R1	P27986	Irs1	Rattus norvegicus	P35570	CoIP	1380456

Cross: Cross-species interaction Intra: Intraspecies interaction

PIK3R1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80516	PI3 Kinase p85 alpha Antibody (YA134)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P80846	Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P80867	PI3 Kinase p85 alpha Antibody (YA689)	WB, IHC-P	Human, Mouse, Rat
HY-P80867A	PI3 Kinase p85 alpha Antibody (YA689)(PBS only)	WB, IHC-P	Human, Mouse, Rat
HY-P810696	Phospho-PI3 Kinase p85/p55 (Tyr458/Tyr199) Antibody (YA9946)	WB, ELISA, IF-Tissue	Human, Mouse, Rat
HY-P84233	PI3 Kinase p85 alpha Antibody (YA3930)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84233A	PI3 Kinase p85 alpha Antibody (YA3930)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P85740	PI3 Kinase p85 alpha Antibody (YA5432)	WB, IHC-P, ICC/IF	Rat, Mouse
HY-P86645	PI3 Kinase p85 alpha Antibody (YA6337)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Short Syndrome	Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly, And Teething Delay Aarskog-Ose-Pande Syndrome Lipodystrophy, Partial, With Rieger Anomaly And Short Stature Lipodystrophy-Rieger Anomaly-Diabetes Syndrome Rieger Anomaly-Partial Lipodystrophy Syndrome Partial Lipodystrophy With Rieger Anomaly And Short Stature Short Stature, Hyperextensibility, Hernia, Ocular Depression, Rieger Anomaly And Teething Delay Growth Retardation-Rieger Anomaly Short Stature-Hyperextensibility-Rieger Anomaly-Teething Delay SHORTS
Agammaglobulinemia 7, Autosomal Recessive	AGM7 Agammaglobulinemia, Autosomal Recessive, Due To Pik3r1 Defect Agammaglobulinemia Autosomal Recessive Due To Pik3r1 Defect Agammaglobulinemia, Type 7, Autosomal Recessive
Immunodeficiency 36	IMD36 Activated Phosphoinositide 3-Kinase Delta Syndrome 2 Immunodeficiency, Type 36
Immunodeficiency 14a, Autosomal Dominant	Activated Pi3k-Delta Syndrome Apds P110-Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency Pasli IMD14A Immunodeficiency 14 P110δ-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation Activated Pi3k-Delta Immunodeficiency Syndrome
Agammaglobulinemia, Non-Bruton Type	Autosomal Agammaglobulinemia
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Congenital Lipomatous Overgrowth, Vascular Malformations, And Epidermal Nevi	Cloves Syndrome Clove Syndrome Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, And Skeletal/Spinal Abnormalities Clove Syndrome, Somatic Nevus Congenital Lipomatous Overgrowth - Vascular Malformation - Epidermal Nevi Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Skeletal Anomaly Syndrome Congenital Lipomatous Overgrowth-Vascular Malformation-Epidermal Nevi-Spinal Anomaly Syndrome CLOVE Congenital Lipomatous Overgrowth Vascular Malformations Epidermal Nevi And Skeletal/Spinal Abnormalities Congenital Arteriovenous Malformation Arteriovenous Hemangioma Melanocytic Nevus Benign Melanocytic Nevus
Uterine Carcinosarcoma	Carcinosarcoma Of The Corpus Uteri Mixed Mullerian Sarcoma Of Uterus Malignant Mixed Müllerian Tumor Of The Corpus Uteri Malignant Mixed Müllerian Tumor Of Corpus Uteri Mixed Müllerian Cancer Of Corpus Uteri Malignant Mixed Mullerian Tumor Of The Corpus Uteri Mixed Mullerian Cancer Of Corpus Uteri Uterine Corpus Carcinosarcoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Agammaglobulinemia 7
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Immunodeficiency 14	Activated Pi3k-Delta Syndrome Apds Pasli Disease Imd14 Senescent T-Cells-Lymphadenopathy-Immunodeficiency Syndrome Due To P110delta-Activating Mutation P110 Delta-Activating Mutation Causing Senescent T Cells, Lymphadenopathy, And Immunodeficiency
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Uterine Corpus Endometrial Carcinoma
Breast Myoepithelial Neoplasm	Breast Myoepithelial Tumor Malignant Breast Myoepithelioma
Breast Adenomyoepithelioma	Adenomyoepithelioma Of The Breast Breast Adenomyoepithelioma With Malignant Change Malignant Adenomyoepithelioma Of Breast
Hypersplenism	Hypersplenia Big Spleen Syndrome Hyperfunction Of Spleen Increased Splenic Activity Spleen Metaplasia Splenic Metaplasia
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Lambda 5 Deficiency
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Growth Retardation With Sensorineural Deafness And Mental Retardation Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Restriction With Sensorineural Deafness And Intellectual Disability Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Female Reproductive Endometrioid Cancer	Endometrioid Tumor Endometrioid Neoplasm Female Reproductive Endometrioid Neoplasm
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Proteus Syndrome	Proteus Syndrome, Somatic Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly Wiedemann'S Syndrome Hemihypertrophy And Macrocephaly Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly Ps PROTEUSS Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly
Uterine Body Mixed Cancer	Malignant Mixed Tumor Of Corpus Uteri Malignant Mixed Tumor, Not Otherwise Specified
Uterine Corpus Cancer	Corpus Uteri Cancer Malignant Uterine Corpus Neoplasm
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Diabetes Mellitus	Diabetes
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6983	Licoricesaponin G2		99.87%	Unkown
HY-161366	OMS14	Inhibitor	99.09%	Unkown
HY-RS10536	PIK3R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18872	Pik3r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25363	Pik3r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PIK3R1	MGD	MGI:97583
Macaca mulatta	PIK3R1	VGNC	VGNC:75999
Bos taurus	PIK3R1	VGNC	VGNC:32894
Felis catus	PIK3R1	VGNC	VGNC:68858
Rattus norvegicus	PIK3R1	RGD	RGD:3329
Canis familiaris	PIK3R1	VGNC	VGNC:44560
Others	PIK3R1	NCBI