2. PI3K/Akt/mTOR
  3. PI3K
  4. OMS14

OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells.

For research use only. We do not sell to patients.

OMS14 Chemical Structure

OMS14 Chemical Structure

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OMS14 Related Antibodies

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Description

OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells[1].

IC50 & Target

PI3Kγ

 

In Vitro

OMS14 (0-100 μM) inhibits proliferations of cells A549 and MCF-7, with IC50s of 22.13 and 26.09 μM, respectively[1].
OMS14 (100 μg/mL) inhibits colony formations of Staphylococcus aureus with an inhibition diameter of 15 mm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OMS14 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549 and MCF-7
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited cell proliferations.
Molecular Weight

454.50

Formula

C21H22N6O4S
SMILES

O=C(CN1CCN(CC(NC2=CC=C([N+]([O-])=O)C=C2)=O)CC1)NC3=NC4=C(S3)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OMS14 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OMS14OMS 14OMS-14PI3KPhosphoinositide 3-kinaseA549MCF-7non-small cell lung cancerbreast cancerInhibitorinhibitorinhibit

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