CBL - Cbl proto-oncogene Gene

Also Known as CBL2; NSLL; C-CBL; RNF55; FRA11B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 867

About CBL

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,206,339-119,308,149 (from NCBI)

This gene has 6 transcripts (splice variants), 264 orthologues, 2 paralogues and is associated with 119 phenotypes. Broad expression in testis (RPKM 12.3), lymph node (RPKM 6.0) and 23 other tissues.

Summary

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin Ligase. The encoded protein is one of the Enzymes required for targeting substrates for degradation by the Proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating Enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for Proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]

CBL Products (1)

mRNA	Protein	Name
NM_005188.4	NP_005179.2	E3 ubiquitin-protein ligase CBL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	9447983	GOA
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	18034775	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	5668240	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18070883	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25178484	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17003487	GOA
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15465819	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	17974561	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	17094949	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25178484	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29237719	GOA
located in cilium	IDA IDA: Inferred from direct assay	29237719	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15465819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBL Protein Structure

Cbl_N

Cbl_N2

Cbl_N3

zf-C3HC4_3

UBA

0
200
400
600
800
906 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence

CBL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CBL	P22681	NTRK1	Homo sapiens	P04629	Anti Bait CoIP	21570973
Intra	CBL	P22681	MET	Homo sapiens	P08581	CoIP	11894096
Intra	CBL	P22681	MET	Homo sapiens	P08581	PLA	25241761
Intra	CBL	P22681	MET	Homo sapiens	P08581	ITC	18273061
Intra	CBL	P22681	MET	Homo sapiens	P08581	SLCA	21163258
Intra	CBL	P22681	MET	Homo sapiens	P08581	X-Ray Diffraction	18273061
Intra	CBL	P22681	MET	Homo sapiens	P08581	SPR	21163258
Intra	CBL	P22681	ZAP70	Homo sapiens	P43403	SPR	22266821
Intra	CBL	P22681	ZAP70	Homo sapiens	P43403	X-Ray Diffraction	22266821
Intra	CBL	P22681	MAPK8	Homo sapiens	P45983	Anti Bait CoIP	16982329
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	Pull Down	23799367
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	IF	16914641
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	ITC	18273061
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	Anti Bait CoIP	15962011
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	X-Ray Diffraction	18273061
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	Far-WB	7657591
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	Anti Bait CoIP	23799367
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	Anti Bait CoIP	20562913
Intra	CBL	P22681	EGFR	Homo sapiens	P00533	CoIP	8662998
Intra	CBL	P22681	CD2AP	Homo sapiens	Q9Y5K6	Pull Down	17020880
Intra	CBL	P22681	CD2AP	Homo sapiens	Q9Y5K6	Pull Down	11067845
Intra	CBL	P22681	CD2AP	Homo sapiens	Q9Y5K6	Imaging	11067845
Intra	CBL	P22681	CD2AP	Homo sapiens	Q9Y5K6	Anti Bait CoIP	17020880
Intra	CBL	P22681	CD2AP	Homo sapiens	Q9Y5K6	Anti Tag CoIP	25036637
Intra	CBL	P22681	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	25036637
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Y2H	10679202
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	16407834
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Pull Down	11894095
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	10679202
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	12177062
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	11894095
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	ITC	19268472
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	10679202
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	CoIP	11894095
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Bait CoIP	15962011
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Affinity Chrom	14596919
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Y2H	11894095
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	25036637
Intra	CBL	P22681	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	20711168
Intra	CBL	P22681	PIK3R2	Homo sapiens	O00459	TAP	19380743
Intra	CBL	P22681	YWHAZ	Homo sapiens	P63104	Biochemical	11697890
Intra	CBL	P22681	UBE2D2	Homo sapiens	P62837	SPR	22266821
Intra	CBL	P22681	UBE2D2	Homo sapiens	P62837	X-Ray Diffraction	22266821
Intra	CBL	P22681	SPRY4	Homo sapiens	Q9C004	Anti Tag CoIP	18273061
Intra	CBL	P22681	SPRY4	Homo sapiens	Q9C004	ITC	18273061
Intra	CBL	P22681	SPRY4	Homo sapiens	Q9C004	X-Ray Diffraction	18273061
Intra	CBL	P22681	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	25036637
Intra	CBL	P22681	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CBL	P22681	YWHAE	Homo sapiens	P62258	Biochemical	11697890
Intra	CBL	P22681	YWHAB	Homo sapiens	P31946	CoIP	11157475
Intra	CBL	P22681	YWHAG	Homo sapiens	P61981	Biochemical	11697890
Intra	CBL	P22681	YWHAQ	Homo sapiens	P27348	CoIP	15094368
Intra	CBL	P22681	YWHAQ	Homo sapiens	P27348	CoIP	9092538
Intra	CBL	P22681	GRB2	Homo sapiens	P62993	Pull Down	23799367
Intra	CBL	P22681	GRB2	Homo sapiens	P62993	Anti Tag CoIP	25036637
Intra	CBL	P22681	GRB2	Homo sapiens	P62993	Y2H Array	25814554
Intra	CBL	P22681	GRB2	Homo sapiens	P62993	TAP	19380743
Intra	CBL	P22681	GRB2	Homo sapiens	P62993	Pull Down	15677445
Intra	CBL	P22681	F2RL1	Homo sapiens	P55085	Anti Tag CoIP	15708858
Intra	CBL	P22681	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CBL	P22681	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CBL	P22681	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CBL	P22681	SFN	Homo sapiens	P31947	Biochemical	11697890
Intra	CBL	P22681	ITSN1	Homo sapiens	Q15811	Far-WB	16914641
Intra	CBL	P22681	ITSN1	Homo sapiens	Q15811	IF	16914641
Intra	CBL	P22681	ITSN1	Homo sapiens	Q15811	Pull Down	16914641
Intra	CBL	P22681	ITSN1	Homo sapiens	Q15811	Anti Tag CoIP	16914641
Intra	CBL	P22681	SRC	Homo sapiens	P12931	Pull Down	16636290
Intra	CBL	P22681	SRC	Homo sapiens	P12931	Pull Down	17094785
Intra	CBL	P22681	SRC	Homo sapiens	P12931	Competition Binding	17094785
Intra	CBL	P22681	ARHGEF7	Homo sapiens	Q14155	Anti Bait CoIP	16407834
Intra	CBL	P22681	SPRY2	Homo sapiens	O43597	X-Ray Diffraction	18273061
Intra	CBL	P22681	SPRY2	Homo sapiens	O43597	Anti Tag CoIP	18273061
Intra	CBL	P22681	SPRY2	Homo sapiens	O43597	Anti Tag CoIP	16893902
Intra	CBL	P22681	SPRY2	Homo sapiens	O43597	CoIP	12815057
Intra	CBL	P22681	SPRY2	Homo sapiens	O43597	Anti Bait CoIP	15962011
Intra	CBL	P22681	SH2B2	Homo sapiens	O14492	Pull Down	15737992
Intra	CBL	P22681	SH2B2	Homo sapiens	O14492	Anti Tag CoIP	18273061
Intra	CBL	P22681	SYK	Homo sapiens	P43405	X-Ray Diffraction	18273061
Intra	CBL	P22681	SYK	Homo sapiens	P43405	Experimental Interac	15556646
Intra	CBL	P22681	SYK	Homo sapiens	P43405	CoIP	8621719
Intra	CBL	P22681	SYK	Homo sapiens	P43405	ITC	18273061
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Pull Down	16219545
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	TAP	19380743
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	16982329
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Pull Down	9890970
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Far-WB	15556646
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Anti Bait CoIP	7642581
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	Y2H	9160881
Intra	CBL	P22681	PIK3R1	Homo sapiens	P27986	CoIP	8621719
Intra	CBL	P22681	PIK3R3	Homo sapiens	Q92569	Lumier	25814554
Intra	CBL	P22681	CRK	Homo sapiens	P46108	TAP	19380743
Intra	CBL	P22681	CRK	Homo sapiens	P46108	Y2H Array	25814554
Intra	CBL	P22681	CRK	Homo sapiens	P46108	Pull Down	8524328
Intra	CBL	P22681	CRKL	Homo sapiens	P46109	Far-WB	15556646
Intra	CBL	P22681	CRKL	Homo sapiens	P46109	Experimental Interac	15556646
Intra	CBL	P22681	CRKL	Homo sapiens	P46109	Pull Down	8626543
Intra	CBL	P22681	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	CBL	P22681	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	CBL	P22681	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	CBL	P22681	HCK	Homo sapiens	P08631-2	Pull Down	10092522
Cross	CBL	P22681	PLCG1	Sus scrofa	F1SDV6	Pull Down	17372230
Cross	CBL	P22681	lpqN	Mycobacterium tuberculosis	A0A0H3L6J6	Pull Down	30118682

Cross: Cross-species interaction Intra: Intraspecies interaction

CBL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81294	Phospho-CBL (Tyr774) Antibody (YA1014)	WB, IP	Human, Rat
HY-P81294A	Phospho-CBL (Ser669) Antibody (YA1015)	WB	Human
HY-P81294AA	Phospho-CBL (Ser669) Antibody (YA1015)(PBS only)	WB	Human
HY-P82647	CBL Antibody (YA2392)	WB, ICC/IF, IP	Human
HY-P82647A	CBL Antibody (YA2392)(PBS only)	WB, ICC/IF, IP	Human
HY-P84192	CBL Antibody (YA3889)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84192A	CBL Antibody (YA3889)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P85077	Cbl Antibody (YA4769)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia	NSLL Cbl Syndrome Noonan Syndrome-Like Disorder With Juvenile Myelomonocytic Leukemia Cbl Mutation-Associated Syndrome Noonan Syndrome-Like Disorder With Jmml
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Fragile Site 11b	FRA11B
Pseudo-Turner Syndrome	Noonan Syndrome
Noonan Syndrome And Noonan-Related Syndrome
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Rhabdomyosarcoma
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Aggressive Systemic Mastocytosis	Asm Lymphadenopathic Mastocytosis With Eosinophilia
Ovarian Germ Cell Cancer	Ovarian Germ Cell Tumor Malignant Germ Cell Tumor Of Ovary Germ Cell Neoplasm Of Ovary Germ Cell Tumor Of Ovary Mogct Malignant Ovarian Germ Cell Tumor Malignant Ovarian Germ Cell Neoplasm
Jacobsen Syndrome	Chromosome 11q Deletion Syndrome Partial 11q Monosomy Syndrome Jacobsen Distal 11q Deletion Syndrome JBS 11q Partial Monosomy Syndrome Chromosome 11q Deletion 11q Deletion 11q Monosomy Deletion 11q Monosomy 11q Partial Monosomy 11q 11q Deletion Disorder 11q Deletion Syndrome 11q Terminal Deletion Disorder 11q- Deletion Syndrome 11q23 Deletion Disorder Jacobsen Thrombocytopenia 11q Terminal Deletion Syndrome Del(11)(Q23.3) Del(11)(Qter) Distal Deletion 11q Distal Monosomy 11q Monosomy 11qter Telomeric Deletion 11q Paris-Trousseau Thrombocytopenia
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Thanatophoric Dysplasia, Type I	Thanatophoric Dysplasia Thanatophoric Dwarfism Thanatophoric Dysplasia Type 1 TD1 Td Thanatophoric Short Stature Thanatophoric Dwarfism Type 1 Thanatophoric Dysplasia Type I Platyspondylic Lethal Skeletal Dysplasia, San Diego Type Lethal Short-Limbed Platyspondylic Dwarfism, San Diego Type Skeletal Dysplasia, San Diego Type Plsd San Diego Type Thanatophoric Dwarfism 1 Dwarfism Thanatophoric Dwarf, Thanatophoric Thanatophoric Dysplasia 1 Lethal Short-Limbed Platyspondylic Dwarfism San Diego Type Platyspondylic Lethal Skeletal Dysplasia San Diego Type Thanatophoric Dwarf Thanatophoric Dwarfism Or Short Stature Thanatophoric Dwarfism Syndrome Td - [Thanatophoric Dwarfism]
Saethre-Chotzen Syndrome	SCS Acs3 Acs Iii Chotzen Syndrome Acrocephaly, Skull Asymmetry, And Mild Syndactyly Acrocephalosyndactyly Type 3 Acrocephalosyndactyly, Type Iii Acrocephalosyndactyly Type Iii Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies Auralcephalosyndactyly Acs 3 Acrocephalo-Syndactyly, Type 3 Blepharophimosis,Epicanthus Inversus, And Ptosis 3 Aural Cephalosyndactyly Kurczynski-Casperson Syndrome Acrocephalosyndactyly Iii Dysostosis Craniofacialis With Hypertelorism Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies Sakati Syndrome
Systemic Mastocytosis	Systemic Mast Cell Disease Systemic Tissue Mast Cell Disease Mastocytosis, Systemic Smcd - Systemic Mast Cell Disease Smcd Mast Cell Disease, Systemic Systemic Mast-Cell Disease Systemic Mastocytoses Mastocytosis Systemic Corneal Dystrophy, Subepithelial Mucinous Smcd - [Systemic Mast Cell Disease]
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Vitamin B12 Deficiency	Cobalamin Deficiency Hypocobalaminemia Vitamin B 12 Deficiency Cyanocobalamin Deficiency Deficiency Of Vitamin B12
Vitamin Metabolic Disorder
Brill-Zinsser Disease	Recrudescent Typhus Brill Disease Brill Zinsser Disease Brill'S Disease Latent Typhus Sporadic Typhus Typhus, Epidemic Louse-Borne Recrudescent Typhus Due To Rickettsia Prowazekii Recrudescent Typhus Fever Recrudescent Brill-Zinsser Typhus Due To Rickettsia Prowazekii Recrudescent Brill Disease Recrudescent Typhus Fever Due To Rickettsia Prowazekii
Pernicious Anemia	Anemia, Pernicious Anemia Pernicious Pernicious Anaemia Addison'S Anaemia Biermer'S Anaemia Biermer'S Anemia Acquired Pernicious Anemia Addison-Biermer Anemia Addisonian Anemia Biermer Anemia Biermer'S Disease Juvenile Onset Pernicious Anemia Biermer Disease Biermer-Addison Disease
Megaloblastic Anemia	Imerslund-Grasbeck Syndrome Igs Defect Of Enterocyte Intrinsic Factor Receptor Enterocyte Cobalamin Malabsorption Familial Megaloblastic Anemia Megaloblastic Anemia 1 Selective Cobalamin Malabsorption With Proteinuria Imerslund-Gräsbeck Syndrome Anemia, Megaloblastic Grasbeck-Imerslund Syndrome Megaloblastic Anaemia Mga1 Norwegian Type Recessive Hereditary Megaloblastic Anaemia 1 Recessive Hereditary Megaloblastic Anemia 1 Rh-Mga1 Gräsbeck-Imerslund Disease Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12 Anemia Megaloblastic Megaloblastic Anemia Due To Inborn Errors Of Metabolism 3-@Methylglutaconic Aciduria, Type I
Methylmalonic Acidemia	Methylmalonic Aciduria Mma Acidemia, Methylmalonic Isolated Methylmalonic Acidemia
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Ptosis	Blepharoptosis Drooping Eyelid Droopy Eyelid Ptosis Of Eyelid Paralysis Of Levator Palpebrae Superioris
Methylmalonic Aciduria And Homocystinuria, Cbld Type	Homocystinuria, Cbld Type, Variant 1 Methylmalonic Aciduria And Homocystinuria Type Cbld Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2 MAHCD Methylmalonic Acidemia And Homocystinuria, Cbld Type Methylmalonic Aciduria, Cblh Type, Formerly Methylmalonic Acidemia, Cblh Type, Formerly Methylmalonic Aciduria, Cbld Type, Variant 2 Cobalamin D Deficiency Methylcobalamin Deficiency Type Cbldv1 Functional Methionine Synthase Deficiency Type Cbldv1 Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2 Methylmalonic Acidemia With Homocystinuria, Type Cbld Cbld Defect Cobalamin D Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld Methylmalonic Aciduria With Homocystinuria, Type Cbld Homocystinuria Cbld Variant 1 Methylmalonic Acidemia And Homocystinuria Cbld Type Methylmalonic Aciduria And Homocystinuria Cbld-Combined Methylmalonic Aciduria And Homocystinuria Cbld Original Methylmalonic Aciduria Cbld Variant 2 Aciduria, Methylmalonic, And Homocystinuria, Cbld Type
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2209	Hydroxocobalamin		99.32%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18935	CBL0137		99.73%	Phase 2
HY-18935A	CBL0137 hydrochloride		99.72%	Phase 2

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141432	NX-1607	Inhibitor	99.87%	Unkown
HY-136339	Cbl-b-IN-1	Inhibitor	99.66%	Unkown
HY-155120	Cbl-b-IN-5	Inhibitor	99.05%	Unkown
HY-P10412	A11	Inhibitor	98.49%	Unkown
HY-W176629	Hydrocotarnine	Inhibitor	99.70%	Unkown
HY-156766	Cbl-b-IN-10	Inhibitor	98.85%	Unkown
HY-155477	Cbl-b-IN-15	Inhibitor	99.78%	Unkown
HY-156765	Cbl-b-IN-9	Inhibitor	98.55%	Unkown
HY-161977	Cbl-b-IN-26	Inhibitor	99.81%	Unkown
HY-156769	Cbl-b-IN-13	Inhibitor	98.46%	Unkown
HY-141431	Cbl-b-IN-2	Inhibitor	/	Unkown
HY-156768	Cbl-b-IN-12	Inhibitor	/	Unkown
HY-E70079	Cystathionine β-lyase, Recombinant Microorganisms		/	Unkown
HY-156762	Cbl-b-IN-6	Inhibitor	/	Unkown
HY-156763	Cbl-b-IN-7	Inhibitor	/	Unkown
HY-156764	Cbl-b-IN-8	Inhibitor	/	Unkown
HY-156767	Cbl-b-IN-11	Inhibitor	/	Unkown
HY-158171	Cbl-b-IN-17	Inhibitor	/	Unkown
HY-158172	Cbl-b-IN-18	Inhibitor	/	Unkown
HY-158173	Cbl-b-IN-19	Inhibitor	/	Unkown
HY-158174	Cbl-b-IN-20	Inhibitor	/	Unkown
HY-159608	PROTAC Cbl-b-IN-1	Degrader	/	Unkown
HY-159615	Cbl-b-IN-21	Degrader	/	Unkown
HY-159617	Cbz-Pip-2C-Pip-C-Pip		/	Unkown
HY-159618	(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip		/	Unkown
HY-163194	Cbl-b-IN-16	Inhibitor	/	Unkown
HY-164133	SM00465	Inhibitor	/	Unkown
HY-169005	Cbl-b-IN-27	Inhibitor	/	Unkown
HY-173311	Cbl-b-IN-28		/	Unkown
HY-179575	Cbl-b-IN-29		/	Unkown
HY-179617	Cbl-b-IN-30	Inhibitor	/	Unkown
HY-183293	Cbl-b-IN-32	Inhibitor	/	Unkown
HY-183997	Cbl-b-IN-33		/	Unkown
HY-184236	Cbl-b-IN-34	Inhibitor	/	Unkown
HY-P10412A	A11 acetate	Inhibitor	98.48%	Unkown
HY-P11479	Cbl-b-IN-31	Inhibitor	/	Unkown
HY-P11481	FITC-Acp-RpYTPEP-NH2	Ligand	/	Unkown
HY-RS01996	CBL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W797329	(3S)Lenalidomide-5-Br		98.61%	Unkown
HY-141432G	NX-1607 (GMP)	Inhibitor	/	Unkown
HY-RS17014	Cbl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23457	Cbl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CBL	MGD	MGI:88279
Macaca mulatta	CBL	VGNC	VGNC:70554
Rattus norvegicus	CBL	RGD	RGD:1561386
Canis familiaris	CBL	VGNC	VGNC:38758
Felis catus	CBL	VGNC	VGNC:108361
Bos taurus	CBL	VGNC	VGNC:26808
Others	CBL	NCBI