Cbl-b-IN-32
Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263.
For research use only. We do not sell to patients.
- Formula: C16H17F3N2O
- Molecular Weight:310.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Cbl-b 6.83 μM (IC50) |
In Vitro
Cbl-b-IN-32 (compound 27) (2-50 μM) directly binds to purified His-Cbl-b protein, inducing a concentration-dependent decrease in protein thermal stability with a ΔTm of -7.0 °C at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 310.31
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Formula C16H17F3N2O
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SMILES
O=C1C(C2=CC=CC(C(CCN)C)=C2)=CC(C(F)(F)F)=CN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cbl-b-IN-32 Related Classifications
HY-183293 Related Classifications
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