2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Cbl-b-IN-32

Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263.

For research use only. We do not sell to patients.

Cbl-b-IN-32

Cbl-b-IN-32 Chemical Structure

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Cbl-b-IN-32 Related Antibodies

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Description

Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM. Cbl-b-IN-32 binds to the TKB-LH interface, stabilizes the inactive conformation of Cbl-b, engages Tyr363 via hydrogen bonds and water bridges, and forms hydrogen bonds with Phe261 and Phe263[1].

IC50 & Target[1]

Cbl-b

6.83 μM (IC50)

In Vitro

Cbl-b-IN-32 (compound 27) (2-50 μM) directly binds to purified His-Cbl-b protein, inducing a concentration-dependent decrease in protein thermal stability with a ΔTm of -7.0 °C at 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cbl-b-IN-32 Related Antibodies
Molecular Weight

310.31

Formula

C16H17F3N2O
SMILES

O=C1C(C2=CC=CC(C(CCN)C)=C2)=CC(C(F)(F)F)=CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cbl-b-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cbl-b-IN-32E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligasemolecular dynamics simulationsPhe261Cbl-bHis-Cbl-b proteinprotein thermal stabilityPDB ID: 9FQJTyr363fluorescence polarization-based competitive binding assayTKB-LH interfacePhe263Inhibitorinhibitorinhibit

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HY-183293
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