SYK - spleen associated tyrosine kinase Gene

Also Known as IMD82; p72-Syk

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6850

About SYK

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:90,801,600-90,898,549 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 32 paralogues and is associated with 82 phenotypes. Broad expression in lymph node (RPKM 32.4), appendix (RPKM 24.8) and 20 other tissues.

Summary

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

SYK Products (9)

mRNA	Protein	Name
NM_001135052.4	NP_001128524.1	tyrosine-protein kinase SYK isoform Syk(S)
XM_047423810.1	XP_047279766.1	tyrosine-protein kinase SYK isoform X2
XM_047423811.1	XP_047279767.1	tyrosine-protein kinase SYK isoform X3
NM_001174167.3	NP_001167638.1	tyrosine-protein kinase SYK isoform Syk(L)
NM_001174168.3	NP_001167639.1	tyrosine-protein kinase SYK isoform Syk(S)
XM_005252147.5	XP_005252204.1	tyrosine-protein kinase SYK isoform X1
NM_003177.7	NP_003168.2	tyrosine-protein kinase SYK isoform Syk(L)
XM_011518946.4	XP_011517248.1	tyrosine-protein kinase SYK isoform X1
XM_047423809.1	XP_047279765.1	tyrosine-protein kinase SYK isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	12885943	GOA
enables interleukin-15 receptor binding	IPI IPI: Inferred from physical interaction	15123770	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	9490415	GOA
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8163536	GOA
enables non-membrane spanning protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	14656219	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	14656219	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7761456	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	18818202	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	23071339	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	8629002	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	34634301	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	33782605	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	11606584	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	31145836	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15509800	GOA
involved in amyloid-beta clearance	IDA IDA: Inferred from direct assay	27477018	GOA
involved in cellular response to amyloid-beta	IDA IDA: Inferred from direct assay	29518356	GOA
involved in cellular response to lipid	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11606584	GOA
involved in intracellular signal transduction	IGI IGI: Inferred from genetic interaction	14656219	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	32514138	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	12885943	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	12885943	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11606584	GOA
involved in peptidyl-tyrosine phosphorylation	IGI IGI: Inferred from genetic interaction	14656219	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	11606584	GOA
involved in positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	18369315	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	34634301	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	19358895	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	19358895	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19358895	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	19358895	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	25251945	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	22267217	GOA
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	19358895	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19358895	GOA
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	23071339	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17681949	GOA
acts upstream of or within regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23071339	GOA
involved in regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19151749	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23071339	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23071339	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23071339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYK Protein Structure

SH2

Pkinase_Tyr

0
100
200
300
400
500
600
635 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase SYK	spleen tyrosine kinase

SYK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYK	P43405	MET	Homo sapiens	P08581	FPS	24728074
Intra	SYK	P43405	CD3E	Homo sapiens	P07766	SPR	7761456
Intra	SYK	P43405	CD3E	Homo sapiens	P07766	Pull Down	7761456
Intra	SYK	P43405	LCK	Homo sapiens	P06239	Far-WB	8798676
Intra	SYK	P43405	LCK	Homo sapiens	P06239	Y2H	8798676
Intra	SYK	P43405	USP25	Homo sapiens	Q9UHP3	Y2H Array	32296183
Intra	SYK	P43405	USP25	Homo sapiens	Q9UHP3	Validated Y2H	32296183
Intra	SYK	P43405	USP25	Homo sapiens	Q9UHP3	Pull Down	32707033
Intra	SYK	P43405	USP25	Homo sapiens	Q9UHP3	Y2H Prey Pooling	25416956
Intra	SYK	P43405	USP25	Homo sapiens	Q9UHP3	Y2H Prey Pooling	32296183
Intra	SYK	P43405	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	SYK	P43405	CLEC7A	Homo sapiens	Q9BXN2	Anti Bait CoIP	31875558
Intra	SYK	P43405	FLT3	Homo sapiens	P36888	Anti Bait CoIP	24525236
Intra	SYK	P43405	FLT3	Homo sapiens	P36888	Protein Kinase Assay	24525236
Intra	SYK	P43405	SH2D2A	Homo sapiens	Q9NP31	Y2H Prey Pooling	25416956
Intra	SYK	P43405	SH2D2A	Homo sapiens	Q9NP31	Validated Y2H	25416956
Intra	SYK	P43405	SH2D2A	Homo sapiens	Q9NP31	Y2H Array	25416956
Intra	SYK	P43405	FCER1G	Homo sapiens	P30273	Pull Down	9280292
Intra	SYK	P43405	FCER1G	Homo sapiens	P30273	Kinase SPA	8810294
Intra	SYK	P43405	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	SYK	P43405	CBL	Homo sapiens	P22681	Experimental Interac	15556646
Intra	SYK	P43405	STAT3	Homo sapiens	P40763	Y2H Array	31515488
Intra	SYK	P43405	STAT3	Homo sapiens	P40763	Y2H Prey Pooling	25416956
Intra	SYK	P43405	STAT3	Homo sapiens	P40763	Y2H Prey Pooling	32296183
Intra	SYK	P43405	STAT3	Homo sapiens	P40763	Y2H Array	32296183
Intra	SYK	P43405	STAT3	Homo sapiens	P40763	Y2H Array	25416956
Intra	SYK	P43405	CD37	Homo sapiens	P11049	Anti Bait CoIP	22624718
Intra	SYK	P43405	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	SYK	P43405	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SYK	P43405	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	SYK	P43405	PLCG1	Homo sapiens	P19174	CoIP	8657103
Intra	SYK	P43405	TENT5A	Homo sapiens	Q96IP4	Lumier	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

SYK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810592	Phospho-Syk (Tyr352) Antibody (YA9856)	WB, ICC/IF, FC	Human
HY-P84328	SYK Antibody (YA4025)	ICC/IF, FC, ELISA	Human
HY-P84328A	SYK Antibody (YA4025)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P84329	SYK Antibody (YA4026)	WB, FC, ELISA	Human
HY-P84329A	SYK Antibody (YA4026)(PBS only)	WB, FC, ELISA	Human
HY-P86108	Phospho-SYK(Tyr525/526)Antibody(YA5800)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86168	Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860)	WB, ICC/IF, ELISA	Human, Mouse
HY-P86408	SYK Antibody (YA6100)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Phaeohyphomycosis	Infection By Dematiacious Fungi Phaehyphomycosis Phaeomycosis Pheohyphomycosis Infection By Dematiacious Fungi [Phaehyphomycosis] Dematiaceous Fungal Infection
Vulvovaginal Candidiasis	Candidiasis Of Vulva And Vagina Candidiasis, Vulvovaginal Candidal Vulvovaginitis Candidal: Cervix Monilial Vulvovaginitis Candidiasis Vulvovaginal
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Bleeding Disorder, Platelet-Type, 11	BDPLT11 Glycoprotein Vi Deficiency Gp Vi Deficiency Platelet-Type Bleeding Disorder 11 Bleeding Diathesis Due To A Collagen Receptor Defect Bleeding Diathesis Due To Glycoprotein Vi Deficiency Platelet-Type Bleeding Disorder-11 Bleeding Disorder, Platelet Type 11 Hemorrhage
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Fungal Infectious Disease	Mycoses Mycosis
Immunodeficiency 82 With Systemic Inflammation	IMD82
Colitis
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Epidermolysis Bullosa Acquisita	Acquired Epidermolysis Bullosa Eb Acquisita Eba Eba - [Epidermolysis Bullosa Acquisita]
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Fasciitis
Chromoblastomycosis	Chromomycosis Mossy Foot Disease Verrucous Dermatitis Fonseca Disease Pedroso Disease Drechslera Hawaiiensis Drechslera Infection
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Carbapenem Allergy
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive
Subcutaneous Mycosis	Subcutaneous Fungal Disease
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Phenytoin Allergy	Dilantin Allergy
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Autoimmune Glomerulonephritis
Cd45 Deficiency
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Chlorhexidine Allergy
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13038A	Fostamatinib	Inhibitor	99.70%	Yes
HY-13038	Fostamatinib Disodium	Inhibitor	98.94%	Yes
HY-13038B	Fostamatinib disodium hexahydrate	Inhibitor	99.46%	Yes

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15968	Entospletinib	Inhibitor	99.49%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Phase 3
HY-15322	PRT062607	Inhibitor	99.38%	Phase 2
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2
HY-103018	Gusacitinib	Inhibitor	99.63%	Phase 2
HY-109091	Lanraplenib	Inhibitor	99.13%	Phase 2
HY-109082	Cevidoplenib	Inhibitor	99.58%	Phase 2
HY-109091B	Lanraplenib succinate	Inhibitor	98.09%	Phase 2
HY-112319	(R,S)-MK-8457		/	Phase 2
HY-100867	Mivavotinib	Inhibitor	/	Phase 2
HY-109091A	Lanraplenib monosuccinate	Inhibitor	/	Phase 2
HY-103018A	Gusacitinib hydrochloride	Inhibitor	/	Phase 2
HY-13518	Piceatannol	Inhibitor	98.97%	Phase 1
HY-112809	GSK2646264	Inhibitor	99.74%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991734	VHB937	Activator	99.9%	Phase 2
HY-P991954	GT103		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (68)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12067	R406	Inhibitor	97.91%	Unkown
HY-14985	BAY 61-3606 dihydrochloride	Inhibitor	99.45%	Unkown
HY-11108	R406 free base	Inhibitor	99.07%	Unkown
HY-100867A	Mivavotinib monohydrochloride	Inhibitor	99.91%	Unkown
HY-N0805	Alisol B 23-acetate	Inhibitor	99.65%	Unkown
HY-12974	PRT-060318	Inhibitor	99.59%	Unkown
HY-145598	Sovleplenib	Inhibitor	99.94%	Unkown
HY-N7675	Flavanomarein	Inhibitor	99.92%	Unkown
HY-78263	MNS	Inhibitor	99.55%	Unkown
HY-112390A	Syk Inhibitor II	Inhibitor	98.15%	Unkown
HY-174369	TREM2 agonist-3	Activator	99.39%	Unkown
HY-76474A	BAY 61-3606 hydrochloride	Inhibitor	98.08%	Unkown
HY-12736A	GSK143 dihydrochloride	Inhibitor	99.37%	Unkown
HY-131341	Syk-IN-4	Inhibitor	98.0%	Unkown
HY-16420	R112	Inhibitor	98.90%	Unkown
HY-136198	SRX3207	Inhibitor	98.50%	Unkown
HY-P6442	Chemerin15	Inhibitor	99.65%	Unkown
HY-16902	RO9021	Inhibitor	98.88%	Unkown
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown
HY-112386	OXSI-2	Inhibitor	99.9%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-160142	UBX-382	Inhibitor	96.20%	Unkown
HY-109082A	Cevidoplenib dimesylate	Inhibitor	98.96%	Unkown
HY-18623	VI 16832	Ligand	99.09%	Unkown
HY-182702	As48	Activator	/	Unkown
HY-178324	T2M-010	Activator	/	Unkown
HY-108489	ER-27319 maleate	Inhibitor	99.4%	Unkown
HY-178129	MRL-SYKi	Inhibitor	98.97%	Unkown
HY-156872	MTX-216	Inhibitor	/	Unkown
HY-10230S	Midostaurin-d5	Inhibitor	98.0%	Unkown
HY-12974A	PRT-060318 dihydrochloride	Inhibitor	98.98%	Unkown
HY-112390	Syk Inhibitor II dihydrochloride	Inhibitor	/	Unkown
HY-138961	ER-27319	Inhibitor	98.66%	Unkown
HY-12657	Syk-IN-1	Inhibitor	99.18%	Unkown
HY-76474	BAY 61-3606	Inhibitor	98.21%	Unkown
HY-124146	BI1002494	Inhibitor	/	Unkown
HY-184063	Vexicitinib	Inhibitor	/	Unkown
HY-145029	SYK/JAK-IN-1	Inhibitor	/	Unkown
HY-155513	Syk-IN-8	Inhibitor	/	Unkown
HY-P2505	Syk Kinase Peptide Substrate		/	Unkown
HY-120214	TAS05567	Inhibitor	/	Unkown
HY-184655	Syk-IN-16	Inhibitor	/	Unkown
HY-181546	Ibt-DOX	Control	/	Unkown
HY-124605	IQS-019	Inhibitor	/	Unkown
HY-184415	Syk/HDAC6-IN-1	Inhibitor	/	Unkown
HY-12736	GSK143	Inhibitor	/	Unkown
HY-P2504	Syk Kinase Peptide Substrate, Biotin labeled		/	Unkown
HY-112390B	Syk Inhibitor II dihydrochloride dihydrate	Inhibitor	/	Unkown
HY-15322A	(rel)-PRT062607	Inhibitor	/	Unkown
HY-125500	TOP1362	Inhibitor	/	Unkown
HY-162427	NMS-0963	Inhibitor	/	Unkown
HY-112390C	Syk Inhibitor II hydrochloride	Inhibitor	/	Unkown
HY-184306	SYK-IN-15	Inhibitor	/	Unkown
HY-112319A	MK-8457	Inhibitor	/	Unkown
HY-103018S	Gusacitinib-d4		/	Unkown
HY-156196	BI 894416	Inhibitor	/	Unkown
HY-125585	Syk-IN-2	Inhibitor	/	Unkown
HY-169630	DBMB	Inhibitor	/	Unkown
HY-149895	Syk-IN-7	Inhibitor	/	Unkown
HY-174284	Syk-IN-13	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-18911	Type-II-IN-1	Inhibitor	/	Unkown
HY-120533	Syk-IN-11	Inhibitor	/	Unkown
HY-160930	TOP1288	Inhibitor	/	Unkown
HY-N3702	Dehydroabietinol	Inhibitor	98.90%	Unkown
HY-N7314	Asebogenin	Inhibitor	/	Unkown
HY-183924	SYK-IN-14	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SYK	VGNC	VGNC:65876
Mus musculus	SYK	MGD	MGI:99515
Bos taurus	SYK	VGNC	VGNC:35513
Macaca mulatta	SYK	VGNC	VGNC:78063
Canis familiaris	SYK	VGNC	VGNC:47021
Rattus norvegicus	SYK	RGD	RGD:3796
Others	SYK	NCBI