2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling Epigenetics
  3. Syk JAK
  4. Vexicitinib

Vexicitinib (Vexicitinibum) is a SYK and JAK2 inhibitor with IC50 values both less than 10 nM. Vexicitinib exhibits anti-inflammatory and immunosuppressive effects. Vexicitinib can be used in tumor-related research.

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Vexicitinib

Vexicitinib Chemical Structure

CAS No. : 2230362-69-1

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Vexicitinib Related Antibodies

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Description

Vexicitinib (Vexicitinibum) is a SYK and JAK2 inhibitor with IC50 values both less than 10 nM. Vexicitinib exhibits anti-inflammatory and immunosuppressive effects. Vexicitinib can be used in tumor-related research[1][2].

IC50 & Target[2]

JAK2

<10 nM (IC50)

Syk

<10 nM (IC50)

In Vitro

Vexicitinib (Compound C10R) potently inhibits purified SYK protein kinase activity with an IC50 of <10 nM[2].
Vexicitinib potently inhibits purified JAK2 protein kinase activity with an IC50 of <10 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vexicitinib Related Antibodies
Parmacokinetics
Species Dose Route Tmax T1/2 Cmax AUC0-24
Mice[2] 5 mg/kg p.o. 0.5 h 2.41 h 451.36 ng/mL 1243.51 ng/mL·h
Molecular Weight

485.56

Formula

C22H27N7O4S
CAS No.
SMILES

O=S(N1C[C@@]2([H])N(CC1)C3=CC=C(NC4=NC=C(C(N)=O)C(NC5CC5)=N4)C=C3OC2)(C6CC6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Vexicitinib Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vexicitinib2230362-69-1VexicitinibumSykJAKSpleen tyrosine kinaseJanus kinaseSYKCDKSGSHFAKFLT-3JAK2tumorsEGFRAxlInhibitorinhibitorinhibit

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