1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Syk
    Autophagy

Piceatannol (Synonyms: Astringenin; trans-Piceatannol)

Cat. No.: HY-13518 Purity: 99.49%
Handling Instructions

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk.

For research use only. We do not sell to patients.

Piceatannol Chemical Structure

Piceatannol Chemical Structure

CAS No. : 10083-24-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
10 mg USD 79 In-stock
Estimated Time of Arrival: December 31
25 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg USD 228 In-stock
Estimated Time of Arrival: December 31
100 mg USD 324 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

    Piceatannol purchased from MCE. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23.

    Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects. In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (126.92 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0943 mL 20.4717 mL 40.9433 mL
    5 mM 0.8189 mL 4.0943 mL 8.1887 mL
    10 mM 0.4094 mL 2.0472 mL 4.0943 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    244.24

    Formula

    C₁₄H₁₂O₄

    CAS No.

    10083-24-6

    SMILES

    OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    Piceatannol
    Cat. No.:
    HY-13518
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    Piceatannol

    Cat. No.: HY-13518