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Piceatannol

(Synonyms: Astringenin; trans-Piceatannol)
26 Cited Publications
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Based on 26 publication(s) in Google Scholar

Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.

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  • Purity: 98.97%
  • CAS No.: 10083-24-6
  • Formula: C14H12O4
  • Molecular Weight:244.24
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Piceatannol Chemical Structure
    Piceatannol Chemical Structure
  • Experimental Validation Results for Piceatannol
  • Experimental Validation Results for Piceatannol
  • Experimental Validation Results for Piceatannol
  • Experimental Validation Results for Piceatannol
  • Experimental Validation Results for Piceatannol
  • Experimental Validation Results for Piceatannol
CAS No.: 10083-24-6
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  • Piceatannol Chemical Structure
    Piceatannol Chemical Structure
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    Piceatannol purchased from MedChemExpress. Usage Cited in: Fundam Res. 2024 Apr 15.

    Customer Validation
     pSHP2 expression in Raw264.7 cells stimulated with 20 ng/mL of recombinant IL-10 for 24 h in the presence of the inhibitors PP2 (10 µM), UNC2025 (5 µM) or Piceatannol (40 µM).

  • 1/16

    Piceatannol purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Sep 14;81(1):402. [Abstract]

    Customer Validation
     The cell surface expression of TLR4 on wild type (WT) or TOT/Tmod1−/− BMDMs as determined by flow cytometry. The BMDMs were pretreated with Piceatannol (PIC, 75 µM; 30 min), an Syk inhibitor, or solvent (DMSO), and then stimulated with LPS for 0, 30, 60, and 120 min. The data was expressed as percentage of surface TLR4 by dividing the fluorescence intensities at any time points by the fluorescence intensity at 0 min. n = 7 biological replicates. Flow cytometry data revealed that PIC (75 µM; 30 min) treatment impaired the effects of LPS on surface TLR4.

  • 1/16

    Piceatannol purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2024 Sep 14;81(1):402. [Abstract]

    Customer Validation
     The colocalization of TLR4 (red) with early endosome marker EEA-1 (green) in Piceatannol (PIC, 75 µM; 30 min)-pretreated WT or TOT/Tmod1−/− BMDMs at 0 and 10 min after LPS treatment as observed by confocal microscopy (left panels). The nuclei were counterstained with DAPI (blue). Scale bar = 10 μm.

  • 1/16

    Piceatannol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Sep 21;11(1):4765. [Abstract]

    Customer Validation
     3T3-L1 adipocytes were pretreated with serum-free medium for 4 h and Piceatannol (Pice., 40 μM) for 1 h, followed by treatment with BSA or BSA-conjugated oleate (100 μM) for 30 min. Cells were harvested for immunoblotting with indicated antibodies. The results showed that Piceatannol largely abolished oleic acid-induced phosphorylation of VAV and JNK by inhibiting SYK in 3T3-L1 adipocytes.

  • 1/16

    Piceatannol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Sep 21;11(1):4765. [Abstract]

    Customer Validation
     3T3-L1 adipocytes were pretreated with serum-free medium for 4 h and Piceatannol (40 μM) for 1 h, followed by treatment with BSA or BSA-conjugated oleate (100 μM) for 1 h. Cells were harvested for immunostaining assays.

  • 1/16

    Piceatannol purchased from MedChemExpress. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23. [Abstract]

    Customer Validation
     Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.

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