1. Protein Tyrosine Kinase/RTK
  2. Syk
  3. Piceatannol

Piceatannol (Synonyms: Astringenin; trans-Piceatannol)

Cat. No.: HY-13518 Purity: 98.10%
Handling Instructions

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk.

For research use only. We do not sell to patients.

Piceatannol Chemical Structure

Piceatannol Chemical Structure

CAS No. : 10083-24-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 87 In-stock
Estimated Time of Arrival: December 31
10 mg USD 79 In-stock
Estimated Time of Arrival: December 31
25 mg USD 156 In-stock
Estimated Time of Arrival: December 31
50 mg USD 228 In-stock
Estimated Time of Arrival: December 31
100 mg USD 324 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Piceatannol purchased from MCE. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23.

    Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.
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    Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects. In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

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    Room temperature in continental US; may vary elsewhere

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (126.92 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0943 mL 20.4717 mL 40.9433 mL
    5 mM 0.8189 mL 4.0943 mL 8.1887 mL
    10 mM 0.4094 mL 2.0472 mL 4.0943 mL
    *Please refer to the solubility information to select the appropriate solvent.
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