2. Protein Tyrosine Kinase/RTK Autophagy Apoptosis Metabolic Enzyme/Protease
  3. Syk Autophagy Apoptosis Endogenous Metabolite
  4. Piceatannol

Piceatannol  (Synonyms: Astringenin; trans-Piceatannol)

Cat. No.: HY-13518 Purity: 98.09%
COA Handling Instructions

Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI). Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties. Piceatannol induces apoptosis in DLBCL cell lines. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells.

For research use only. We do not sell to patients.

Piceatannol Chemical Structure

Piceatannol Chemical Structure

CAS No. : 10083-24-6

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Based on 13 publication(s) in Google Scholar

Piceatannol Related Antibodies

Top Publications Citing Use of Products

    Piceatannol purchased from MCE. Usage Cited in: Cell. 2018 Oct 4;175(2):442-457.e23.  [Abstract]

    Syk inhibitors (R406 and Piceatannol) are added during the induction of trastuzumab-dependent BT-474 phagocytosis. The binding of the phagosome marker Rab7 to AIM2 in macrophages are evaluated by co-immunoprecipitation.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI)[1]. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties[2]. Piceatannol induces apoptosis in DLBCL cell lines[3]. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells[4].

    In Vitro

    Piceatannol is a resveratrol metabolite[2].
    SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392,DOHH2,Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Piceatannol Related Antibodies

    Cell Cytotoxicity Assay[3]

    Cell Line: Six DLBCL cell lines (Karpas 422, VAL, SUDHL-6, OCI Ly19, U2392 and DOHH2)
    Concentration: 3.125, 6.25, 12.5, 25, and 50 μM
    Incubation Time: 72 hours
    Result: The IC50s were 18 μM in SUDHL-6, 25 μM in U2392, 37 mM in DOHH2, 48 μM in Karpas 422 and higher than 50 μM in OCI-Ly19 and in VAL.
    In Vivo

    Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and? reduces the infiltration of inflammatory cells induced by lipopolysaccharide[1].
    Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and? inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced by lipopolysaccharide[1].
    Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice (40-50 g)[1]
    Dosage: 10, 20, and 40 mg/kg
    Administration: Intraperitoneally 1 h before LPS challenge
    Result: Significantly reduced the pulmonary edema induced by LPS.
    Molecular Weight

    244.24

    Appearance

    Solid

    Formula

    C14H12O4
    CAS No.
    SMILES

    OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (126.92 mM)

    H2O : 1 mg/mL (4.09 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0943 mL 20.4717 mL 40.9433 mL
    5 mM 0.8189 mL 4.0943 mL 8.1887 mL
    10 mM 0.4094 mL 2.0472 mL 4.0943 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Piceatannol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    × = ×
    C1   V1   C2   V2

    Keywords:

    Piceatannol10083-24-6Astringenin trans-PiceatannolSykAutophagyApoptosisEndogenous MetaboliteSpleen tyrosine kinaseiNOSacutelunginjuryALIanticanceranti-inflammatoryInhibitorinhibitorinhibit

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