TERF1 - telomeric repeat binding factor 1 Gene
Also Known as TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS
Species: Homo sapiens
About TERF1
This gene has 16 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 11.2), ovary (RPKM 9.8) and 25 other tissues.
Summary
This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of Telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Multiple transcripts of this gene are alternatively spliced products. [provided by RefSeq, Aug 2022]
TERF1 Products (14)
| mRNA | Protein | Name |
|---|---|---|
| NM_001410928.1 | NP_001397857.1 | telomeric repeat-binding factor 1 isoform 3 |
| NM_001413364.1 | NP_001400293.1 | telomeric repeat-binding factor 1 isoform 4 |
| NM_001413365.1 | NP_001400294.1 | telomeric repeat-binding factor 1 isoform 5 |
| NM_001413366.1 | NP_001400295.1 | telomeric repeat-binding factor 1 isoform 6 |
| NM_001413367.1 | NP_001400296.1 | telomeric repeat-binding factor 1 isoform 7 |
| NM_001413368.1 | NP_001400297.1 | telomeric repeat-binding factor 1 isoform 8 |
| NM_001413369.1 | NP_001400298.1 | telomeric repeat-binding factor 1 isoform 9 |
| NM_001413370.1 | NP_001400299.1 | telomeric repeat-binding factor 1 isoform 10 |
| NM_001413371.1 | NP_001400300.1 | telomeric repeat-binding factor 1 isoform 11 |
| NM_001413372.1 | NP_001400301.1 | telomeric repeat-binding factor 1 isoform 12 |
| NM_001413373.1 | NP_001400302.1 | telomeric repeat-binding factor 1 isoform 13 |
| NM_001413374.1 | NP_001400303.1 | telomeric repeat-binding factor 1 isoform 14 |
| NM_003218.4 | NP_003209.2 | telomeric repeat-binding factor 1 isoform 2 |
| NM_017489.3 | NP_059523.2 | telomeric repeat-binding factor 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA binding, bending |
IDA
IDA: Inferred from direct assay
|
9130722 | GOA |
| enables G-rich strand telomeric DNA binding |
IDA
IDA: Inferred from direct assay
|
17694070 | GOA |
| enables ankyrin repeat binding |
IPI
IPI: Inferred from physical interaction
|
11854288 | GOA |
| enables double-stranded telomeric DNA binding |
IDA
IDA: Inferred from direct assay
|
1406665 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
9391075 | GOA |
| enables microtubule binding |
IDA
IDA: Inferred from direct assay
|
11943150 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9391075 | GOA |
| enables protein homodimerization activity |
IPI
IPI: Inferred from physical interaction
|
9130722 | GOA |
| contributes to telomerase activity |
IDA
IDA: Inferred from direct assay
|
23685356 | GOA |
| enables telomeric DNA binding |
IDA
IDA: Inferred from direct assay
|
9034193 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in chromosome, telomeric region |
IDA
IDA: Inferred from direct assay
|
9034193 | GOA |
| part of nuclear telomere cap complex |
IDA
IDA: Inferred from direct assay
|
16880378 | GOA |
| located in nucleolus |
IDA
IDA: Inferred from direct assay
|
11701125 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
1406665 | GOA |
| part of shelterin complex |
IDA
IDA: Inferred from direct assay
|
15383534 | GOA |
| part of shelterin complex |
IPI
IPI: Inferred from physical interaction
|
15383534 | GOA |
| colocalizes with spindle |
IDA
IDA: Inferred from direct assay
|
11943150 | GOA |
TERF1 Protein Structure
TRF: Telomere repeat binding factor (TRF) (77 - 268)
Myb_DNA-binding: Myb-like DNA-binding domain (380 - 427)
- 0
- 100
- 200
- 300
- 400
- 439 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
telomeric repeat-binding factor 1 |
|
TERF1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TERF1 | P54274 | MAPRE1 | Homo sapiens | Q15691 | 11701125 | |
|
Intra
|
TERF1 | P54274 | MAPRE1 | Homo sapiens | Q15691 | 11943150 | |
|
Intra
|
TERF1 | P54274 | ACAT2 | Homo sapiens | Q9BWD1 | 21044950 | |
|
Intra
|
TERF1 | P54274 | FES | Homo sapiens | P07332 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TNKS | Homo sapiens | O95271 | 20696165 | |
|
Intra
|
TERF1 | P54274 | TNKS | Homo sapiens | O95271 | 33961781 | |
|
Intra
|
TERF1 | P54274 | TNKS | Homo sapiens | O95271 | 26496610 | |
|
Intra
|
TERF1 | P54274 | CUSTOS | Homo sapiens | Q96C57 | 21044950 | |
|
Intra
|
TERF1 | P54274 | STAG1 | Homo sapiens | Q8WVM7 | 17962804 | |
|
Intra
|
TERF1 | P54274 | TERB1 | Homo sapiens | Q8NA31 | 29083416 | |
|
Intra
|
TERF1 | P54274 | TERB1 | Homo sapiens | Q8NA31 | 29083416 | |
|
Intra
|
TERF1 | P54274 | PRDX6 | Homo sapiens | P30041 | 21044950 | |
|
Cross
|
TERF1 | P54274 | P0C6X7-PRO_0000037315 | Human SARS coronavirus | P0C6X7-PRO_0000037315 | 22046132 | |
|
Cross
|
TERF1 | P54274 | P0C6X7-PRO_0000037315 | Human SARS coronavirus | P0C6X7-PRO_0000037315 | 22046132 | |
|
Intra
|
TERF1 | P54274 | CEP85 | Homo sapiens | Q6P2H3 | 21044950 | |
|
Intra
|
TERF1 | P54274 | DDX39A | Homo sapiens | O00148 | 21044950 | |
|
Intra
|
TERF1 | P54274 | PRDX1 | Homo sapiens | Q06830 | 21044950 | |
|
Intra
|
TERF1 | P54274 | NAP1L1 | Homo sapiens | P55209 | 21044950 | |
|
Intra
|
TERF1 | P54274 | DNAJB1 | Homo sapiens | P25685 | 21044950 | |
|
Intra
|
TERF1 | P54274 | HGD | Homo sapiens | Q93099 | 21044950 | |
|
Intra
|
TERF1 | P54274 | NUB1 | Homo sapiens | Q9Y5A7 | 27214791 | |
|
Intra
|
TERF1 | P54274 | NUB1 | Homo sapiens | Q9Y5A7 | 27214791 | |
|
Intra
|
TERF1 | P54274 | NUB1 | Homo sapiens | Q9Y5A7 | 27214791 | |
|
Intra
|
TERF1 | P54274 | NUB1 | Homo sapiens | Q9Y5A7 | 27214791 | |
|
Intra
|
TERF1 | P54274 | TNPO2 | Homo sapiens | O14787 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TNKS2 | Homo sapiens | Q9H2K2 | 33961781 | |
|
Intra
|
TERF1 | P54274 | BLM | Homo sapiens | P54132 | 15229185 | |
|
Intra
|
TERF1 | P54274 | SOAT1 | Homo sapiens | P35610 | 21044950 | |
|
Intra
|
TERF1 | P54274 | MDH1 | Homo sapiens | P40925 | 21044950 | |
|
Intra
|
TERF1 | P54274 | SUPT5H | Homo sapiens | O00267 | 21044950 | |
|
Intra
|
TERF1 | P54274 | AMPH | Homo sapiens | P49418 | 21044950 | |
|
Intra
|
TERF1 | P54274 | PAK4 | Homo sapiens | O96013 | 21044950 | |
|
Intra
|
TERF1 | P54274 | RNF10 | Homo sapiens | Q8N5U6 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 25416956 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 11701125 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 16169070 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 17589526 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 16880378 | |
|
Intra
|
TERF1 | P54274 | TINF2 | Homo sapiens | Q9BSI4 | 33961781 | |
|
Intra
|
TERF1 | P54274 | DDX19B | Homo sapiens | Q9UMR2 | 21044950 | |
|
Intra
|
TERF1 | P54274 | WFS1 | Homo sapiens | O76024 | 21044950 | |
|
Intra
|
TERF1 | P54274 | LRSAM1 | Homo sapiens | Q6UWE0 | 21044950 | |
|
Intra
|
TERF1 | P54274 | WARS1 | Homo sapiens | P23381 | 21044950 | |
|
Intra
|
TERF1 | P54274 | PINX1 | Homo sapiens | Q96BK5 | 11701125 | |
|
Intra
|
TERF1 | P54274 | PINX1 | Homo sapiens | Q96BK5 | 11701125 | |
|
Intra
|
TERF1 | P54274 | PINX1 | Homo sapiens | Q96BK5 | 27214791 | |
|
Intra
|
TERF1 | P54274 | PINX1 | Homo sapiens | Q96BK5 | 21044950 | |
|
Intra
|
TERF1 | P54274 | RECQL4 | Homo sapiens | O94761 | 21044950 | |
|
Intra
|
TERF1 | P54274 | PPM1G | Homo sapiens | O15355 | 21044950 | |
|
Intra
|
TERF1 | P54274 | ACY1 | Homo sapiens | Q03154 | 21044950 | |
|
Intra
|
TERF1 | P54274 | PACSIN2 | Homo sapiens | Q9UNF0 | 21044950 | |
|
Intra
|
TERF1 | P54274 | DNPH1 | Homo sapiens | O43598 | 21044950 | |
|
Intra
|
TERF1 | P54274 | TRMT1 | Homo sapiens | Q9NXH9 | 21044950 | |
|
Intra
|
TERF1 | P54274 | HCLS1 | Homo sapiens | P14317 | 21044950 | |
|
Intra
|
TERF1 | P54274 | CRYBB1 | Homo sapiens | P53674 | 21044950 | |
|
Intra
|
TERF1 | P54274 | SYK | Homo sapiens | P43405 | 21044950 | |
|
Intra
|
TERF1 | P54274 | KLHDC4 | Homo sapiens | Q8TBB5 | 21044950 | |
|
Intra
|
TERF1 | P54274 | AMPD2 | Homo sapiens | Q01433 | 21044950 | |
|
Intra
|
TERF1 | P54274 | FBXO4 | Homo sapiens | Q9UKT5-1 | 16275645 |
Recombinant TERF1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74493 | TRF1 Protein, Human (sf9, His) | P54274-2/NP_003209 (M1-D419) | ≥ 90%, as determined by reducing SDS-PAGE. |
TERF1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83494 | TERF1 Antibody (YA3239) | WB, ICC/IF | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Townes-Brocks Syndrome |
|
|
| Cherubism |
|
|
| Dyskeratosis Congenita |
|
|
| Dyskeratosis Congenita, Autosomal Dominant 3 |
|
|
| Werner Syndrome |
|
|
| Arthrogryposis, Renal Dysfunction, And Cholestasis 1 |
|
|
| Revesz Syndrome |
|
|
| Acute Leukemia |
|
|
| Ataxia-Telangiectasia |
|
|
| Anaplastic Astrocytoma |
|
|
| Melanoma, Cutaneous Malignant 1 |
|
|
| Coats Disease |
|
|
| Gastric Cancer |
|
|
| Lung Cancer |
|
|
| Aplastic Anemia |
|
|
| Meningioma, Familial |
|
|
| Interstitial Lung Disease 2 |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | TERF1 | MGD | MGI:109634 |
| Canis familiaris | TERF1 | VGNC | VGNC:47254 |
| Bos taurus | TERF1 | VGNC | VGNC:35749 |
| Rattus norvegicus | TERF1 | RGD | RGD:1311574 |
| Felis catus | TERF1 | VGNC | VGNC:66083 |
| Macaca mulatta | TERF1 | VGNC | VGNC:78311 |
| Others | TERF1 | NCBI |