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SUPT5H - SPT5 homolog, DSIF elongation factor subunit Gene

Also Known as SPT5; SPT5H; Tat-CT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6829

About SUPT5H

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,445,582-39,476,670 (from NCBI)

This gene has 20 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 64.5), bone marrow (RPKM 32.4) and 25 other tissues.

Summary

Enables enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT5H Products (12)

mRNA	Protein	Name
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a
NM_001111020.3	NP_001104490.1	transcription elongation factor SPT5 isoform a
NM_001130824.2	NP_001124296.1	transcription elongation factor SPT5 isoform a
NM_001130825.2	NP_001124297.1	transcription elongation factor SPT5 isoform b
NM_001319990.2	NP_001306919.1	transcription elongation factor SPT5 isoform a
NM_001319991.2	NP_001306920.1	transcription elongation factor SPT5 isoform b
NM_003169.4	NP_003160.2	transcription elongation factor SPT5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	10075709	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10075709	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9450929	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in negative regulation of DNA-templated transcription, elongation	IMP IMP: Inferred from mutant phenotype	10075709	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10075709	GOA
involved in positive regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10075709	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DSIF complex	IDA IDA: Inferred from direct assay	9450929	GOA
part of DSIF complex	IPI IPI: Inferred from physical interaction	19860741	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9450929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT5H Protein Structure

Spt5_N

Spt5-NGN

KOW

CTD

0
200
400
600
800
1000
1087 a.a.

Protein Preferred Names	Protein Names
transcription elongation factor SPT5	DRB sensitivity-inducing factor 160 kDa subunit

SUPT5H Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Far-WB	10075709
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	MAPPIT	25416956
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Bait CoIP	10075709
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	26496610
Intra	SUPT5H	O00267	POLR2A	Homo sapiens	P24928	Anti Tag CoIP	35271311
Intra	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Pull Down	16169070
Intra	SUPT5H	O00267	PPIA	Homo sapiens	P62937	Y2H Pooling	16169070
Intra	SUPT5H	O00267	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	SUPT5H	O00267	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	35271311
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	BFG-2H	27107012
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	TAP	24981860
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Anti Tag CoIP	26496610
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Crosslink	26789250
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Pull Down	10075709
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	Y2H Array	31515488
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	MAPPIT	25416956
Intra	SUPT5H	O00267	SUPT4H1	Homo sapiens	P63272	GMS	17404243
Cross	SUPT5H	O00267	POLR2B	Bos taurus	A5PJW8	Crosslink	26789250
Cross	SUPT5H	O00267	PA	Influenza A virus	Q5EP34	Anti Tag CoIP	21715506
Cross	SUPT5H	O00267	POLR2A	Bos taurus	G3MZY8	Crosslink	26789250

Cross: Cross-species interaction Intra: Intraspecies interaction

SUPT5H Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83159	SPT5 Antibody (YA2904)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency With Hyper-Igm, Type 2	HIGM2 Hyper-Igm Syndrome Type 2 Hyper-Igm Syndrome 2 Immunodeficiency With Hyper-Igm Type 2 Activation-Induced Cytidine Deaminase Deficiency Aid Deficiency Immunodeficiency With Hyper Igm Type 2 Hyper Igm Syndrome 2 Immunodeficiency With Hyper-Igm 2 Hyper-Igm Immunodeficiency Type 2 Immunodeficiency, With Hyper Igm, Type 2 Hyper-Igm Immunodeficiency Syndrome, Type 2
Ichthyosis, Congenital, Autosomal Recessive 11	Autosomal Recessive Congenital Ichthyosis 11 Ichthyosis With Hypotrichosis, Autosomal Recessive Arih Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis Autosomal Recessive Ichthyosis With Hypotrichosis ARCI11 Ifah Hypotrichosis-Congenital Ichthyosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome Ichthyosis-Hypotrichosis Syndrome Ifah Syndrome Ihs
Immunodeficiency With Hyper-Igm, Type 1	Immunodeficiency, X-Linked, With Hyper-Igm Hyper Igm Syndrome HIGM1 Xhim Hyper-Igm Syndrome Higm Hyper-Igm Syndrome 1 Immunodeficiency 3 Imd3 Immunodeficiency With Hyper-Igm Immunodeficiency With Hyper Igm Type 1 Ihis X-Linked Hyper Igm Syndrome Hyper-Igm Immunodeficiency, X-Linked Hyper Igm Immunodeficiency, X-Linked Hyper Igm Syndrome 1 X-Linked Immunodeficiency With Hyper-Igm 1 Immunodeficiency, With Hyper Igm Immunodeficiency, With Hyper Igm, Type 1 Hyper-Igm Immunodeficiency Syndrome, Type 1 Hyperimmunoglobulin M Syndrome
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14038	SUPT5H Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SUPT5H	VGNC	VGNC:46992
Mus musculus	SUPT5H	MGD	MGI:1202400
Felis catus	SUPT5H	VGNC	VGNC:65849
Macaca mulatta	SUPT5H	VGNC	VGNC:78056
Bos taurus	SUPT5H	VGNC	VGNC:35481
Rattus norvegicus	SUPT5H	RGD	RGD:1563807
Others	SUPT5H	NCBI