SUPT4H1 - SPT4 homolog, DSIF elongation factor subunit Gene

Also Known as SPT4; SPT4H; SUPT4H; Supt4a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6827

About SUPT4H1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,345,178-58,352,201 (from NCBI)

This gene has 7 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in bone marrow (RPKM 34.4), brain (RPKM 26.3) and 25 other tissues.

Summary

This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

SUPT4H1 Products (1)

mRNA	Protein	Name
NM_003168.3	NP_003159.1	transcription elongation factor SPT4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10075709	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	9450929	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in positive regulation of DNA-templated transcription, elongation	IDA IDA: Inferred from direct assay	9450929	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	9450929	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DSIF complex	IDA IDA: Inferred from direct assay	9450929	GOA
part of DSIF complex	IPI IPI: Inferred from physical interaction	19860741	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9450929	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUPT4H1 Protein Structure

Spt4

0
100
117 a.a.

Protein Preferred Names	Protein Names
transcription elongation factor SPT4	DRB sensitivity-inducing factor 14 kDa subunit

SUPT4H1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	Far-WB	10075709
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	Validated Y2H	27107012
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	Y2H Array	31515488
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	BFG-2H	27107012
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	Y2H Array	25502805
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	Anti Tag CoIP	10075709
Intra	SUPT4H1	P63272	SUPT5H	Homo sapiens	O00267	SLC	27107012

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 36	Spinocerebellar Ataxia Type 36 SCA36 Asidan Ataxia Costa De Morte Ataxia Asidan Ataxia, Spinocerebellar, Type 36
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14037	SUPT4H1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SUPT4H1	VGNC	VGNC:35480
Macaca mulatta	SUPT4H1	VGNC	VGNC:104660
Felis catus	SUPT4H1	VGNC	VGNC:65848
Mus musculus	SUPT4H1	MGD	MGI:107416
Canis familiaris	SUPT4H1	VGNC	VGNC:46991
Rattus norvegicus	SUPT4H1	RGD	RGD:1306372
Others	SUPT4H1	NCBI