2. Gene
  3. SUPT4H1 - SPT4 homolog, DSIF elongation factor subunit Gene

SUPT4H1 - SPT4 homolog, DSIF elongation factor subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPT4; SPT4H; SUPT4H; Supt4a

Gene ID: 6827 | Gene type: protein coding

About SUPT4H1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,345,178-58,352,201 (from NCBI)

This gene has 7 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in bone marrow (RPKM 34.4), brain (RPKM 26.3) and 25 other tissues.

Summary

This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

SUPT4H1 Products(1)

mRNA Protein Name
NM_003168.3 NP_003159.1 transcription elongation factor SPT4

SUPT4H1 Protein Structure

Spt4

Spt4: Spt4/RpoE2 zinc finger (13 - 90)

  • 0
  • 100
  • 117 a.a.
Protein Preferred Names Protein Names

transcription elongation factor SPT4

DRB sensitivity-inducing factor 14 kDa subunit

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 36

Spinocerebellar Ataxia Type 36

SCA36

Asidan Ataxia

Costa De Morte Ataxia

Asidan

Ataxia, Spinocerebellar, Type 36
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14037 SUPT4H1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SUPT4H1 VGNC VGNC:35480
Macaca mulatta SUPT4H1 VGNC VGNC:104660
Felis catus SUPT4H1 VGNC VGNC:65848
Mus musculus SUPT4H1 MGD MGI:107416
Canis familiaris SUPT4H1 VGNC VGNC:46991
Rattus norvegicus SUPT4H1 RGD RGD:1306372