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RNF10 - ring finger protein 10 Gene

Also Known as RIE2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9921

About RNF10

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,534,356-120,577,588 (from NCBI)

This gene has 25 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues.

Summary

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

RNF10 Products (2)

mRNA	Protein	Name
NM_001330474.2	NP_001317403.1	RING finger protein 10 isoform 2
NM_014868.5	NP_055683.3	RING finger protein 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16335786	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	24105792	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16335786	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24105792	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	34348161	GOA
involved in ribosome-associated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	34348161	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16335786	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	34348161	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF10 Protein Structure

zf-C3HC4_2

0
200
400
600
811 a.a.

Protein Preferred Names	Protein Names
RING finger protein 10	epididymis secretory sperm binding protein

RNF10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF10	Q8N5U6	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RNF10	Q8N5U6	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	RNF10	Q8N5U6	CLSTN1	Homo sapiens	O94985-2	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	CLSTN1	Homo sapiens	O94985-2	Y2H Array	32814053
Intra	RNF10	Q8N5U6	CLSTN1	Homo sapiens	O94985-2	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	RNF10	Q8N5U6	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	UBE2E3	Homo sapiens	Q969T4	Y2H Array	19549727
Intra	RNF10	Q8N5U6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	RNF10	Q8N5U6	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	RNF10	Q8N5U6	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RNF10	Q8N5U6	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	RNF10	Q8N5U6	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RNF10	Q8N5U6	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	RNF10	Q8N5U6	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	RNF10	Q8N5U6	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	RNF10	Q8N5U6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	RNF10	Q8N5U6	UBE2D1	Homo sapiens	P51668	Y2H	19549727
Intra	RNF10	Q8N5U6	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19549727
Intra	RNF10	Q8N5U6	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32814053
Intra	RNF10	Q8N5U6	COQ8A	Homo sapiens	Q8NI60	Y2H Pooling	32814053
Intra	RNF10	Q8N5U6	COQ8A	Homo sapiens	Q8NI60	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Superficial Keratitis
Leukodystrophy, Hypomyelinating, 2	Pmld1 Hypomyelinating Leukodystrophy 2 HLD2 Pelizaeus-Merzbacher-Like Disease 1 Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation Pelizaeus-Merzbacher-Like Disease Type 1 Pelizaeus-Merzbacher-Like Disease, 1 Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Pmld - Pelizaeus Merzbacher Like Disease Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1 Pmldar1 Leukodystrophy, Hypomyelinating, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12034	RNF10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20483	Rnf10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26991	Rnf10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF10	MGD	MGI:1859162
Canis familiaris	RNF10	VGNC	VGNC:97218
Bos taurus	RNF10	VGNC	VGNC:34007
Rattus norvegicus	RNF10	RGD	RGD:1309282
Macaca mulatta	RNF10	VGNC	VGNC:76702
Others	RNF10	NCBI