CASP6 - caspase 6 Gene

Homo sapiens

Also known as MCH2; CSP-6

Gene ID: 839 | Gene type: protein coding

About CASP6

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,664,388-109,709,767 (from NCBI)

This gene has 8 transcripts (splice variants), 268 orthologues and 16 paralogues. Broad expression in duodenum (RPKM 18.7), colon (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active Enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream Enzyme in the Caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]

CASP6 Products(5)

mRNA	Protein	Name
NM_032992.3	NP_116787.1	caspase-6 isoform beta
XM_047416244.1	XP_047272200.1	caspase-6 isoform X1
NR_133012.2
NM_001226.4	NP_001217.2	caspase-6 isoform alpha precursor
XM_047416245.1	XP_047272201.1	caspase-6 isoform X2

CASP6 Protein Structure

Peptidase_C14

0
100
200
293 a.a.

Protein Preferred Names

Protein Names

caspase-6

apoptotic protease MCH-2	caspase 6, apoptosis-related cysteine peptidase
caspase 6, apoptosis-related cysteine protease

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against	Alcohol Dependence, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Chronic Adenitis	Acute Adenitis
Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01959	CASP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01960	Casp6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01961	CASP6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CASP6	VGNC	VGNC:70545
Mus musculus	CASP6	MGD	MGI:1312921
Rattus norvegicus	CASP6	RGD	RGD:70967
Bos taurus	CASP6	VGNC	VGNC:26782
Canis familiaris	CASP6	VGNC	VGNC:57400

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