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125113

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7

Inhibitors & Agonists

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19286
    Eflucimibe

    F 12511

    		 Acyltransferase Cancer
    Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor. Eflucimibe can be used in the research of atherosclerosis .
    Eflucimibe
  • HY-W741575
    Iloperidone carboxylic acid

    P95-12113

    		 5-HT Receptor Adrenergic Receptor Dopamine Receptor Neurological Disease
    Iloperidone carboxylic acid (P95-12113) is the metabolite of Iloperidone (HY-17410). Iloperidone carboxylic acid exhibits good affinity for 5-HT2A receptor with pKi of 8.15, and moderate affinity for adrenergic receptor α1/α2B/α2C .
    Iloperidone carboxylic acid
  • HY-R00089
    hsa-miR-12113 mimic

    		MicroRNA Cancer
    hsa-miR-12113 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-12113 mimic
    hsa-miR-12113 mimic
  • HY-167717
    (Rac)-Eflucimibe

    (Rac)-F 12511

    		 Endogenous Metabolite Metabolic Disease
    (Rac)-Eflucimibe ((Rac)-F 12511) is an ACAT inhibitor with endogenous hypercholesterolemia modulating activity. (Rac)-Eflucimibe has shown high potency and efficacy as an anti-hypercholesterol compound in different hypercholesterolemia animal models .
    (Rac)-Eflucimibe
  • HY-R00089A
    hsa-miR-12113 agomir

    		MicroRNA Cancer
    hsa-miR-12113 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-12113 agomir
    hsa-miR-12113 agomir
  • HY-RI00089
    hsa-miR-12113 inhibitor

    		MicroRNA Cancer
    hsa-miR-12113 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-12113 inhibitor
    hsa-miR-12113 inhibitor
  • HY-RI00089A
    hsa-miR-12113 antagomir

    		MicroRNA Cancer
    hsa-miR-12113 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-12113 antagomir
    hsa-miR-12113 antagomir

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