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MRI1 - methylthioribose-1-phosphate isomerase 1 Gene

Also Known as M1Pi; MRDI; MTNA; Ypr118w

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84245

About MRI1

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:13,764,522-13,774,282 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 6.8), skin (RPKM 6.2) and 25 other tissues.

Summary

This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

MRI1 Products (3)

mRNA	Protein	Name
NM_001031727.4	NP_001026897.1	methylthioribose-1-phosphate isomerase isoform 1
NM_001329572.2	NP_001316501.1	methylthioribose-1-phosphate isomerase isoform 3
NM_032285.4	NP_115661.1	methylthioribose-1-phosphate isomerase isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRI1 Protein Structure

IF-2B

0
100
200
300
369 a.a.

Protein Preferred Names	Protein Names
methylthioribose-1-phosphate isomerase	MTR-1-P isomerase

MRI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MRI1	Q9BV20	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	MRI1	Q9BV20	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	MRI1	Q9BV20	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	MRI1	Q9BV20	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	MRI1	Q9BV20	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	MRI1	Q9BV20	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	MRI1	Q9BV20	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	MRI1	Q9BV20	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	MRI1	Q9BV20	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	MRI1	Q9BV20	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	MRI1	Q9BV20	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	MRI1	Q9BV20	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	MRI1	Q9BV20	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	MRI1	Q9BV20	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	MRI1	Q9BV20	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	MRI1	Q9BV20	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	MRI1	Q9BV20	F11R	Homo sapiens	Q9Y624	Validated Y2H	32814053
Intra	MRI1	Q9BV20	F11R	Homo sapiens	Q9Y624	Y2H Pooling	32814053
Intra	MRI1	Q9BV20	F11R	Homo sapiens	Q9Y624	Y2H Array	32814053
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Validated Y2H	32296183
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Y2H Array	25416956
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Y2H Array	32296183
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Y2H Pooling	16189514
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Y2H Pooling	19447967
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Pull Down	16189514
Intra	MRI1	Q9BV20	MRI1	Homo sapiens	Q9BV20	Y2H Prey Pooling	32296183
Intra	MRI1	Q9BV20	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	MRI1	Q9BV20	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	MRI1	Q9BV20	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Infantile Epilepsy Syndrome	Infantile Epilepsy
Achilles Bursitis	Achilles Bursitis Or Tendinitis Capped Hock Haglund'S Deformity Haglund'S Disease Osteochondritis Of The Talus
Atrial Septal Defect 1	ASD1 Atrial Heart Septal Defect 1 Asd
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106594A	Prussian blue insoluble	Inhibitor	99.00%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106594B	Prussian blue soluble	Inhibitor	/	Unkown
HY-115853A	Pyclen dihydrochloride		/	Unkown
HY-115853	Pyclen		99.81%	Unkown
HY-RS08653	MRI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-115853B	Pyclen sulfate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MRI1	MGD	MGI:1915123
Macaca mulatta	MRI1	VGNC	VGNC:74848
Bos taurus	MRI1	VGNC	VGNC:31604
Rattus norvegicus	MRI1	RGD	RGD:1307789
Canis familiaris	MRI1	VGNC	VGNC:43365
Felis catus	MRI1	VGNC	VGNC:63581
Others	MRI1	NCBI