2. Gene
  3. MRI1 - methylthioribose-1-phosphate isomerase 1 Gene

MRI1 - methylthioribose-1-phosphate isomerase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as M1Pi; MRDI; MTNA; Ypr118w

Gene ID: 84245 | Gene type: protein coding

About MRI1

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:13,764,522-13,774,282 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 6.8), skin (RPKM 6.2) and 25 other tissues.

Summary

This Enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

MRI1 Products(3)

mRNA Protein Name
NM_001031727.4 NP_001026897.1 methylthioribose-1-phosphate isomerase isoform 1
NM_001329572.2 NP_001316501.1 methylthioribose-1-phosphate isomerase isoform 3
NM_032285.4 NP_115661.1 methylthioribose-1-phosphate isomerase isoform 2

MRI1 Protein Structure

IF-2B

IF-2B: Initiation factor 2 subunit family (44 - 346)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

methylthioribose-1-phosphate isomerase

MTR-1-P isomerase

Related Diseases

Diseases Alias
Infantile Epilepsy Syndrome

Infantile Epilepsy
Achilles Bursitis

Achilles Bursitis Or Tendinitis

Capped Hock

Haglund'S Deformity

Haglund'S Disease

Osteochondritis Of The Talus
Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16217 Gadobutrol 99.58% Unkown
HY-16217A Gadobutrol hydrate / Unkown
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08653 MRI1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MRI1 MGD MGI:1915123
Macaca mulatta MRI1 VGNC VGNC:74848
Bos taurus MRI1 VGNC VGNC:31604
Rattus norvegicus MRI1 RGD RGD:1307789
Canis familiaris MRI1 VGNC VGNC:43365
Felis catus MRI1 VGNC VGNC:63581