COG6 - component of oligomeric golgi complex 6 Gene

Also Known as COD2; SHNS; CDG2L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57511

About COG6

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:39,655,627-39,791,666 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 7.0), thyroid (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

COG6 Products (2)

mRNA	Protein	Name
NM_001145079.2	NP_001138551.1	conserved oligomeric Golgi complex subunit 6 isoform 2
NM_020751.3	NP_065802.1	conserved oligomeric Golgi complex subunit 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	27066481	GOA
involved in glycosylation	IMP IMP: Inferred from mutant phenotype	20605848	GOA
involved in retrograde transport, vesicle recycling within Golgi	IMP IMP: Inferred from mutant phenotype	27066481	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Golgi transport complex	IDA IDA: Inferred from direct assay	15047703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COG6 Protein Structure

COG6

0
200
400
600
657 a.a.

Protein Preferred Names	Protein Names
conserved oligomeric Golgi complex subunit 6	COG complex subunit 6

COG6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COG6	Q9Y2V7	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33961781
Intra	COG6	Q9Y2V7	ARHGEF5	Homo sapiens	Q12774	Validated Y2H	27107012
Intra	COG6	Q9Y2V7	ZBTB16	Homo sapiens	Q05516	Validated Y2H	27107012
Intra	COG6	Q9Y2V7	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	COG6	Q9Y2V7	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	27107012
Intra	COG6	Q9Y2V7	BCL10	Homo sapiens	O95999	Validated Y2H	27107012

Cross: Cross-species interaction Intra: Intraspecies interaction

COG6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82785	COG6 Antibody (YA2530)	WB	Human, Mouse
HY-P82785A	COG6 Antibody (YA2530)(PBS only)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type Iil	CDG2L Congenital Disorder Of Glycosylation Type Iil Cdg Iil Cog6-Cgd Cdgiil Cdg Syndrome Type Iil Congenital Disorder Of Glycosylation Type 2l Cdg-Iil Cdgiidl Congenital Disorder Of Glycosylation 2l Glycosylation, Congenital Disorder Of, Type Iil
Shaheen Syndrome	Hypohidrosis-Enamel Hypoplasia-Palmoplantar Keratoderma-Intellectual Disability Syndrome SHNS
Congenital Disorder Of Glycosylation, Type Iih	CDG2H Congenital Disorder Of Glycosylation Type Iih Cdg Iih Cdgiih Carbohydrate Deficient Glycoprotein Syndrome Type Iih Congenital Disorder Of Glycosylation Type 2h Cog8-Cdg Cdg-Iih Cdgiidh Cdg Syndrome Type Iih Congenital Disorder Of Glycosylation 2h Glycosylation, Congenital Disorder Of, Type Iih
Congenital Disorder Of Glycosylation, Type Iiq	CDG2Q Cdg Iiq Cdgiiq Congenital Disorder Of Glycosylation Type Iiq Cog2-Cdg Cog2-Related Congenital Disorder Of Glycosylation Cdgiidq Congenital Disorder Of Glycosylation 2q Cdg-Iiq
Congenital Disorder Of Glycosylation, Type Iij	CDG2J Congenital Disorder Of Glycosylation Type Iij Cdg Iij Cdgiij Carbohydrate Deficient Glycoprotein Syndrome Type Iij Cdg Syndrome Type Iij Congenital Disorder Of Glycosylation Type 2j Cog4-Cdg Cdg-Iij Cdgiidj Congenital Disorder Of Glycosylation 2j Glycosylation, Congenital Disorder Of, Type Iij
Immunodeficiency 47	Congenital Disorder Of Glycosylation Type Ii CDG2E Congenital Disorder Of Glycosylation Type Iie IMD47 Cdg2s Cdg Iis Cdgiis Immunodeficiency And Hepatopathy With Or Without Neurologic Features Congenital Disorder Of Glycosylation, Type Ii CDG1I Congenital Disorder Of Glycosylation, Type Iie Cdg Iie Congenital Disorder Of Glycosylation Type 2e Congenital Disorder Of Glycosylation, Type Iis Cdg Ii Cdgii Cdgiie Carbohydrate Deficient Glycoprotein Syndrome Type Iie Cdg Syndrome Type Iie Congenital Disorder Of Glycosylation Ii Congenital Disorder Of Glycosylation 1i Cdg-Iie Alg2-Cdg Cdg-Ii Glycosylation, Congenital Disorder Of, Type Ii Cdgiide Congenital Disorder Of Glycosylation Type Iis Cog7-Cdg Cdg Syndrome Type Ii Carbohydrate Deficient Glycoprotein Syndrome Type Ii Congenital Disorder Of Glycosylation Type 1i Mannosyltransferase 2 Deficiency Congenital Disorder Of Glycosylation 2e Congenital Disorder Of Glycosylation 2s Congenital Disorders Of Glycosylation Type Ii Glycosylation, Congenital Disorder Of, Type Iie Immunodeficiency, Type 47 Congenital Disorder Of Glycosylation Type 2a
Congenital Disorder Of Glycosylation, Type Iii	CDG2I Congenital Disorder Of Glycosylation Type Iii Cdgiii Carbohydrate Deficient Glycoprotein Syndrome Type Iii Congenital Disorder Of Glycosylation Type 2i Cog5-Cdg Cdgiidi Congenital Disorder Of Glycosylation 2i Glycosylation, Congenital Disorder Of, Type Iii Congenital Disorder Of Glycosylation, Type I-Iix
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02955	COG6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	COG6	VGNC	VGNC:39452
Felis catus	COG6	VGNC	VGNC:61049
Rattus norvegicus	COG6	RGD	RGD:1303283
Mus musculus	COG6	MGD	MGI:1914792
Bos taurus	COG6	VGNC	VGNC:27550
Macaca mulatta	COG6	VGNC	VGNC:71207
Others	COG6	NCBI