ARHGEF5 - Rho guanine nucleotide exchange factor 5 Gene

Homo sapiens

Also known as P60; TIM; GEF5; TIM1

Gene ID: 7984 | Gene type: protein coding

About ARHGEF5

Cytogenetic location: 7q35 Genomic coordinates (GRCh38): 7:144,355,402-144,380,632 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 198 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 23.4), skin (RPKM 15.6) and 23 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

ARHGEF5 Products(1)

mRNA	Protein	Name
NM_005435.4	NP_005426.2	rho guanine nucleotide exchange factor 5

ARHGEF5 Protein Structure

ARHGEF5_35

RhoGEF

SH3_9

0
300
600
900
1200
1500
1597 a.a.

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 5

Rho guanine nucleotide exchange factor (GEF) 5

Related Diseases

Diseases

Alias

Rippling Muscle Disease 2

Rippling Muscle Disease	Rmd
Lgmd1c	RMD2
Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c	Muscular Dystrophy, Limb-Girdle, Type 1c
Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly	Lgmd1c, Formerly
Limb-Girdle Muscular Dystrophy Type 1c	Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency
Muscular Dystrophy, Limb-Girdle, Type Ic	Rippling Muscle Syndrome
Limb-Girdle Muscular Dystrophy 1c	Dystrophy, Muscular, Limb-Girdle, Type 1c
Disease, Muscle, Rippling, Type 2	Rippling Muscle Disease 1

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00962	ARHGEF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF5	VGNC	VGNC:38090
Macaca mulatta	ARHGEF5	VGNC	VGNC:80793
Bos taurus	ARHGEF5	VGNC	VGNC:26119
Mus musculus	ARHGEF5	MGD	MGI:1858952
Rattus norvegicus	ARHGEF5	RGD	RGD:620718

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