TRIM27 - tripartite motif containing 27 Gene

Homo sapiens

Also known as RFP; RNF76

Gene ID: 5987 | Gene type: protein coding

About TRIM27

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,903,002-28,923,985 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 152 orthologues, 80 paralogues and is associated with 48 phenotypes. Ubiquitous expression in thyroid (RPKM 14.7), spleen (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the RET transforming protein. [provided by RefSeq, Jul 2008]

TRIM27 Products(1)

mRNA	Protein	Name
NM_006510.5	NP_006501.1	zinc finger protein RFP

Protein Preferred Names

Protein Names

zinc finger protein RFP

RFP transforming protein

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Schaaf-Yang Syndrome

Prader-Willi-Like Syndrome	Chitayat-Hall Syndrome
SHFYNG	Pwls
Magel2-Related Prader-Willi-Like Syndrome	Magel2-Related Pwls
Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies	Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A
Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies	Pws Due To A Point Mutation
Pws Due To Point Mutation	Prader-Willi Syndrome Due To A Point Mutation
Prader-Willi Syndrome Due To Point Mutation	Pws-Like

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15032	TRIM27 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIM27	RGD	RGD:1310105
Macaca mulatta	TRIM27	VGNC	VGNC:81596
Mus musculus	TRIM27	MGD	MGI:97904
Bos taurus	TRIM27	VGNC	VGNC:36323
Canis familiaris	TRIM27	VGNC	VGNC:97226
Felis catus	TRIM27	VGNC	VGNC:69300

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