STK25 - serine/threonine kinase 25 Gene

Also Known as SOK1; YSK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10494

About STK25

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,492,670-241,509,572 (from NCBI)

This gene has 35 transcripts (splice variants), 208 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 17.8), thyroid (RPKM 17.1) and 25 other tissues.

Summary

This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

STK25 Products (9)

mRNA Protein Name
NM_001271977.2 NP_001258906.1 serine/threonine-protein kinase 25 isoform 1
NM_001271978.2 NP_001258907.1 serine/threonine-protein kinase 25 isoform 1
NM_001271979.2 NP_001258908.1 serine/threonine-protein kinase 25 isoform 2
NM_001271980.2 NP_001258909.1 serine/threonine-protein kinase 25 isoform 2
NM_001282305.1 NP_001269234.1 serine/threonine-protein kinase 25 isoform 3
NM_001282306.2 NP_001269235.1 serine/threonine-protein kinase 25 isoform 4
NM_001282307.2 NP_001269236.1 serine/threonine-protein kinase 25 isoform 3
NM_001282308.2 NP_001269237.1 serine/threonine-protein kinase 25 isoform 3
NM_006374.5 NP_006365.2 serine/threonine-protein kinase 25 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15037601 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
15037601 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi localization IDA
IDA: Inferred from direct assay
15037601 GOA
involved in Golgi reassembly IMP
IMP: Inferred from mutant phenotype
20332113 GOA
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
22291017 GOA
involved in establishment of Golgi localization IMP
IMP: Inferred from mutant phenotype
20332113 GOA
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide IGI
IGI: Inferred from genetic interaction
22652780 GOA
involved in positive regulation of stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
22652780 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
17657516 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
17657516 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
18782753 GOA
colocalizes with Golgi apparatus IDA
IDA: Inferred from direct assay
22652780 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22652780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK25 Protein Structure

Pkinase

Pkinase: Protein kinase domain (21 - 270)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 25

  • Ste20, yeast homolog

STK25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STK25 O00506 STRN Homo sapiens O43815
Anti Tag CoIP
28514442
Intra
STK25 O00506 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
Intra
STK25 O00506 STRN Homo sapiens O43815
Anti Tag CoIP
35271311
Intra
STK25 O00506 STRN Homo sapiens O43815
TAP
23455922
Intra
STK25 O00506 STRN Homo sapiens O43815
Pull Down
32707033
Intra
STK25 O00506 STRN Homo sapiens O43815
Anti Tag CoIP
33961781
Intra
STK25 O00506 CAB39 Homo sapiens Q9Y376
Anti Tag CoIP
33961781
Intra
STK25 O00506 CAB39 Homo sapiens Q9Y376
Anti Tag CoIP
28514442
Intra
STK25 O00506 CAB39 Homo sapiens Q9Y376
Anti Tag CoIP
21423148
Intra
STK25 O00506 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
STK25 O00506 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
TAP
23455922
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
26871637
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Pull Down
32707033
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Validated Y2H
27107012
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Y2H Array
26871637
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Validated Y2H
26871637
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Y2H
15037601
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Anti Tag CoIP
28514442
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
BFG-2H
27107012
Intra
STK25 O00506 GOLGA2 Homo sapiens Q08379
Anti Tag CoIP
33961781
Intra
STK25 O00506 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
STK25 O00506 TRIM27 Homo sapiens P14373
Validated Y2H
26871637
Intra
STK25 O00506 TRIM27 Homo sapiens P14373
Y2H Array
26871637
Intra
STK25 O00506 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
26871637
Intra
STK25 O00506 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra
STK25 O00506 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
TAP
23455922
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
Y2H Prey Pooling
25416956
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
Protein Kinase Assay
17657516
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
Y2H Array
25416956
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
Y2H Pooling
16189514
Intra
STK25 O00506 PDCD10 Homo sapiens Q9BUL8
Anti Tag CoIP
18782753
Intra
STK25 O00506 CCNDBP1 Homo sapiens O95273
Validated Y2H
32296183
Intra
STK25 O00506 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra
STK25 O00506 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
STK25 O00506 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
25416956
Intra
STK25 O00506 IHO1 Homo sapiens Q8IYA8
Validated Y2H
25416956
Cross
STK25 O00506 Golga2 Rattus norvegicus Q62839
Y2H
15037601
Cross
STK25 O00506 Golga2 Rattus norvegicus Q62839
Pull Down
15037601
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Chromosome 2q37 Deletion Syndrome

  • Albright Hereditary Osteodystrophy-Like Syndrome

  • 2q37 Microdeletion Syndrome

  • Brachydactyly-Intellectual Disability Syndrome

  • Deletion 2q37

  • 2q37 Deletion Syndrome

  • Brachydactyly-Mental Retardation Syndrome

  • Bdmr

  • Albright Hereditary Osteodystrophy Type 3

  • Del(2)(Q37)

  • Monosomy 2q37qter

  • Albright'S Hereditary Osteodystrophy-Like Syndrome

  • Monosomy 2q37

  • Chromosome Deletion Syndrome 2q37
Cerebrocostomandibular Syndrome

  • Cerebro-Costo-Mandibular Syndrome

  • CCMS

  • Rib Gap Defects With Micrognathia

  • Ccm Syndrome
Pseudopseudohypoparathyroidism

  • PPHP

  • Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

  • Normocalcemic Pseudohypoparathyroidism

  • Aho-Pphp Syndrome

  • Albright Hereditary Osteodystrophy-Pphp Syndrome

  • Pseudohypoparathyroidism
Cavernous Hemangioma

  • Hemangioma, Cavernous

  • Cavernoma

  • Cavernous Haemangioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13928 STK25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20107 Stk25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26611 Stk25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus STK25 VGNC VGNC:35391
Canis familiaris STK25 VGNC VGNC:46909
Rattus norvegicus STK25 RGD RGD:727809
Mus musculus STK25 MGD MGI:1891699
Macaca mulatta STK25 VGNC VGNC:81584
Felis catus STK25 VGNC VGNC:80368
Others STK25 NCBI