CAB39 - calcium binding protein 39 Gene

Also Known as MO25; CGI-66

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51719

About CAB39

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,712,842-230,821,075 (from NCBI)

This gene has 6 transcripts (splice variants), 139 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 18.8), appendix (RPKM 18.4) and 25 other tissues.

Summary

Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic Cancer. [provided by Alliance of Genome Resources, Apr 2022]

CAB39 Products (3)

mRNA Protein Name
NM_001130849.2 NP_001124321.1 calcium-binding protein 39
NM_001130850.2 NP_001124322.1 calcium-binding protein 39
NM_016289.4 NP_057373.1 calcium-binding protein 39

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
19892943 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14676191 GOA
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
19892943 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
19892943 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
24393035 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
24393035 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
24393035 GOA
involved in positive regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19892943 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
24393035 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14517248 GOA
part of serine/threonine protein kinase complex IPI
IPI: Inferred from physical interaction
19892943 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAB39 Protein Structure

Mo25

Mo25: Mo25-like (1 - 334)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

calcium-binding protein 39

  • MO25alpha

CAB39 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Validated Y2H
32296183
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Y2H Array
32296183
Intra
CAB39 Q9Y376 STK24 Homo sapiens Q9Y6E0-2
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6
Anti Tag CoIP
33961781
Intra
CAB39 Q9Y376 MCCD1 Homo sapiens P59942
Y2H Array
32296183
Intra
CAB39 Q9Y376 MCCD1 Homo sapiens P59942
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STRADA Homo sapiens Q7RTN6-1
Anti Bait CoIP
26479318
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
Comigration in SDS
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
Anti Tag CoIP
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
BLI
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
X-Ray Diffraction
23434407
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289-1
GMS
23434407
Intra
CAB39 Q9Y376 STK39 Homo sapiens Q9UEW8
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STK39 Homo sapiens Q9UEW8
SPR
21423148
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Tag CoIP
33961781
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Affinity Chrom
15733851
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Bait CoIP
26479318
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
Anti Tag CoIP
14676191
Intra
CAB39 Q9Y376 STK11 Homo sapiens Q15831
PLA
25241761
Intra
CAB39 Q9Y376 STRADB Homo sapiens Q9C0K7
Y2H Fragment Pooling
23414517
Intra
CAB39 Q9Y376 STRADB Homo sapiens Q9C0K7
Anti Tag CoIP
14676191
Intra
CAB39 Q9Y376 MED7 Homo sapiens O43513
Y2H Array
32296183
Intra
CAB39 Q9Y376 MED7 Homo sapiens O43513
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289
Anti Tag CoIP
21423148
Intra
CAB39 Q9Y376 STK26 Homo sapiens Q9P289
SPR
21423148
Intra
CAB39 Q9Y376 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CAB39 Q9Y376 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 OXSR1 Homo sapiens O95747
SPR
21423148
Intra
CAB39 Q9Y376 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra
CAB39 Q9Y376 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CAB39 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83016 CAB39 Antibody (YA2761) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P83016A CAB39 Antibody (YA2761)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01778 CAB39 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01779 CAB39L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CAB39 VGNC VGNC:60281
Canis familiaris CAB39 VGNC VGNC:38619
Mus musculus CAB39 MGD MGI:107438
Bos taurus CAB39 VGNC VGNC:26661
Rattus norvegicus CAB39 RGD RGD:1306390
Macaca mulatta CAB39 VGNC VGNC:70590
Others CAB39 NCBI