STRADA - STE20 related adaptor alpha Gene

Also Known as LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92335

About STRADA

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,702,832-63,741,986 (from NCBI)

This gene has 54 transcripts (splice variants), 212 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 18.6), brain (RPKM 8.0) and 24 other tissues.

Summary

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

STRADA Products (15)

mRNA	Protein	Name
NM_001003786.3	NP_001003786.1	STE20-related kinase adapter protein alpha isoform 2
NM_001003787.4	NP_001003787.1	STE20-related kinase adapter protein alpha isoform 1
NM_001003788.3	NP_001003788.1	STE20-related kinase adapter protein alpha isoform 4
NM_001165969.2	NP_001159441.1	STE20-related kinase adapter protein alpha isoform 5
NM_001165970.2	NP_001159442.1	STE20-related kinase adapter protein alpha isoform 6
NM_001363786.1	NP_001350715.1	STE20-related kinase adapter protein alpha isoform 7
NM_001363787.1	NP_001350716.1	STE20-related kinase adapter protein alpha isoform 8
NM_001363788.1	NP_001350717.1	STE20-related kinase adapter protein alpha isoform 9
NM_001363789.1	NP_001350718.1	STE20-related kinase adapter protein alpha isoform 10
NM_001363790.1	NP_001350719.1	STE20-related kinase adapter protein alpha isoform 11
NM_001363791.1	NP_001350720.1	STE20-related kinase adapter protein alpha isoform 12
NM_001411083.1	NP_001398012.1	STE20-related kinase adapter protein alpha isoform 13
NM_001411084.1	NP_001398013.1	STE20-related kinase adapter protein alpha isoform 14
NM_001411085.1	NP_001398014.1	STE20-related kinase adapter protein alpha isoform 15
NM_153335.6	NP_699166.2	STE20-related kinase adapter protein alpha isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	19892943	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12805220	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	19892943	GOA
NOT enables protein kinase activity	IDA IDA: Inferred from direct assay	12805220	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	12805220	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of negative effect G1 to G0 transition	IPI IPI: Inferred from physical interaction	12805220	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	12805220	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	12805220	GOA
NOT involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12805220	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12805220	GOA
part of intracellular protein-containing complex	IDA IDA: Inferred from direct assay	12805220	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12805220	GOA
part of serine/threonine protein kinase complex	IPI IPI: Inferred from physical interaction	19892943	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRADA Protein Structure

Pkinase

0
100
200
300
400
431 a.a.

Protein Preferred Names	Protein Names
STE20-related kinase adapter protein alpha	STE20-like pseudokinase

STRADA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STRADA	Q7RTN6	STK11	Homo sapiens	Q15831	Anti Bait CoIP	12805220
Intra	STRADA	Q7RTN6	STK11	Homo sapiens	Q15831	IF	12805220
Intra	STRADA	Q7RTN6	STK11	Homo sapiens	Q15831	Affinity Chrom	15733851
Intra	STRADA	Q7RTN6	STK11	Homo sapiens	Q15831	Y2H	12805220
Intra	STRADA	Q7RTN6	STK11	Homo sapiens	Q15831	Anti Tag CoIP	12805220
Intra	STRADA	Q7RTN6	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	21423148

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy	Pmse Syndrome PMSE Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy Syndrome Pretzel Syndrome Polyhydramnios-Megalencephaly-Symptomatic Epilepsy Syndrome
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy
Megalencephaly	Macroencephaly Macrencephaly
Polyhydramnios
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Scheuermann Disease	Scheuermann'S Disease Spinal Osteochondrosis Juvenile Osteochondrosis Of Spine Familial Scheuermann Disease Familial Scheuermann Juvenile Kyphosis Familial Spinal Osteochondrosis Scheuermann Juvenile Kyphosis Juvenile Osteochondritis Of The Spine Juvenile Osteochondrosis Of Scheurermann Scheuermann'S Kyphosis Sherman'S Disease Juvenile Kyphosis Scheuermann Kyphosis [X]Spinal Osteochondrosis, Unspecified
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13959	STRADA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STRADA	VGNC	VGNC:35418
Canis familiaris	STRADA	VGNC	VGNC:46939
Macaca mulatta	STRADA	VGNC	VGNC:81589
Mus musculus	STRADA	MGD	MGI:1919399
Rattus norvegicus	STRADA	RGD	RGD:727905
Felis catus	STRADA	VGNC	VGNC:97649
Others	STRADA	NCBI