NOD2 - nucleotide binding oligomerization domain containing 2 Gene

Also Known as CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64127

About NOD2

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,693,606-50,733,075 (from NCBI)

This gene has 17 transcripts (splice variants), 167 orthologues, 20 paralogues and is associated with 9 phenotypes. Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues.

Summary

This gene is a member of the NOD1/Apaf-1 family and encodes a protein with two Caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular Bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

NOD2 Products (18)

mRNA	Protein	Name
XM_047434453.1	XP_047290409.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721242.5	XP_006721305.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X1
XM_047434454.1	XP_047290410.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
NM_001293557.2	NP_001280486.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 2
NM_022162.3	NP_071445.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 1
NR_163434.1
XM_017023537.2	XP_016879026.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X3
XM_011523260.4	XP_011521562.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XR_007064895.1
NM_001370466.1	NP_001357395.1	nucleotide-binding oligomerization domain-containing protein 2 isoform 2
XM_047434457.1	XP_047290413.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X8
XM_047434452.1	XP_047290408.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X2
XM_006721243.5	XP_006721306.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X5
XR_007064894.1
XM_011523261.3	XP_011521563.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X4
XM_047434456.1	XP_047290412.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X7
XM_047434455.1	XP_047290411.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X6
XM_017023536.2	XP_016879025.1	nucleotide-binding oligomerization domain-containing protein 2 isoform X3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11087742	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	24790089	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	24790089	GOA
enables actin binding	IDA IDA: Inferred from direct assay	24790089	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15753091	GOA
enables muramyl dipeptide binding	IDA IDA: Inferred from direct assay	12871942	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	12871942	GOA
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	15998797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11472070	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15075345	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17337451	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	23300079	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antibacterial innate immune response	IDA IDA: Inferred from direct assay	20406817	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27812135	GOA
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21887730	GOA
involved in cellular response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	25093298	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	12514169	GOA
involved in detection of bacterium	IDA IDA: Inferred from direct assay	15653568	GOA
acts upstream of or within detection of muramyl dipeptide	IDA IDA: Inferred from direct assay	12527755	GOA
involved in detection of muramyl dipeptide	IDA IDA: Inferred from direct assay	15998797	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23806334	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	15653568	GOA
involved in maintenance of gastrointestinal epithelium	IMP IMP: Inferred from mutant phenotype	17058067	GOA
acts upstream of or within nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	12527755	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	12626759	GOA
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	31649195	GOA
involved in positive regulation of B cell activation	IDA IDA: Inferred from direct assay	20844241	GOA
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12527755	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11385577	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16203728	GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	12527755	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11087742	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15998797	GOA
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	16260731	GOA
involved in positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	24671169	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	15107016	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	21040358	GOA
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	17919942	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	16414084	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24790089	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25093298	GOA
involved in positive regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25891078	GOA
acts upstream of or within positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	17187069	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21887730	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	17187069	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21040358	GOA
involved in positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	21172192	GOA
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	12514169	GOA
involved in response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	24790089	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16203728	GOA
located in cell surface	IDA IDA: Inferred from direct assay	16714539	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21887730	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21887730	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	19701189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14570728	GOA
is active in extrinsic component of plasma membrane	IDA IDA: Inferred from direct assay	17355968	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	31649195	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	17355968	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15998797	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	31649195	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21887730	GOA
located in vesicle	IDA IDA: Inferred from direct assay	15998797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOD2 Protein Structure

CARD

NACHT

LRR_6

0
200
400
600
800
1040 a.a.

Protein Preferred Names	Protein Names
nucleotide-binding oligomerization domain-containing protein 2	NLR family, CARD domain containing 2 NOD-like receptor C2 caspase recruitment domain family, member 15 caspase recruitment domain protein 15 caspase recruitment domain-containing protein 15 inflammatory bowel disease protein 1 nucleotide-binding oligomerization domain 2 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

NOD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NOD2	Q9HC29	GALNT2	Homo sapiens	Q10471	Anti Bait CoIP	21699783
Intra	NOD2	Q9HC29	GALNT2	Homo sapiens	Q10471	Y2H	21699783
Intra	NOD2	Q9HC29	FIS1	Homo sapiens	Q9Y3D6	Y2H	21699783
Intra	NOD2	Q9HC29	FIS1	Homo sapiens	Q9Y3D6	Anti Bait CoIP	21699783
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Anti Bait CoIP	22684479
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Anti Bait CoIP	21699783
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Anti Tag CoIP	35273242
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Y2H	21699783
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Anti Tag CoIP	22684479
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	Y2H	22684479
Intra	NOD2	Q9HC29	VIM	Homo sapiens	P08670	IF	22684479
Intra	NOD2	Q9HC29	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	22829933
Intra	NOD2	Q9HC29	RIPK2	Homo sapiens	O43353	Anti Tag CoIP	21931826
Intra	NOD2	Q9HC29	RIPK2	Homo sapiens	O43353	CoIP	11087742
Intra	NOD2	Q9HC29	NDUFA13	Homo sapiens	Q9P0J0	Confocal	15753091
Intra	NOD2	Q9HC29	NDUFA13	Homo sapiens	Q9P0J0	Y2H	15753091
Intra	NOD2	Q9HC29	NDUFA13	Homo sapiens	Q9P0J0	Anti Tag CoIP	15753091
Intra	NOD2	Q9HC29	KAT5	Homo sapiens	Q92993	Anti Bait CoIP	21699783
Intra	NOD2	Q9HC29	KAT5	Homo sapiens	Q92993	Y2H	21699783
Intra	NOD2	Q9HC29	CASP1	Homo sapiens	P29466	Anti Tag CoIP	18511561
Intra	NOD2	Q9HC29	TRIM27	Homo sapiens	P14373	Pull Down	22829933
Intra	NOD2	Q9HC29	TRIM27	Homo sapiens	P14373	Anti Tag CoIP	22829933
Intra	NOD2	Q9HC29	TRIM27	Homo sapiens	P14373	Anti Bait CoIP	22829933
Intra	NOD2	Q9HC29	TRIM27	Homo sapiens	P14373	IF	22829933
Intra	NOD2	Q9HC29	ERBIN	Homo sapiens	Q96RT1-2	Anti Tag CoIP	16203728
Intra	NOD2	Q9HC29	ERBIN	Homo sapiens	Q96RT1-2	Anti Bait CoIP	16203728
Intra	NOD2	Q9HC29	PPP2R5E	Homo sapiens	Q16537	Y2H	21699783
Intra	NOD2	Q9HC29	PPP2R5E	Homo sapiens	Q16537	Anti Bait CoIP	21699783
Intra	NOD2	Q9HC29	ERBIN	Homo sapiens	Q96RT1	Pull Down	30833792
Intra	NOD2	Q9HC29	ERBIN	Homo sapiens	Q96RT1	Anti Tag CoIP	16203728
Intra	NOD2	Q9HC29	ERBIN	Homo sapiens	Q96RT1	Confocal	16203728

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Iritis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Pyoderma
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Familial Cold Autoinflammatory Syndrome	Familial Cold Urticaria Fcas Familial Polymorphous Cold Eruption Fcu Cold Hypersensitivity
Yao Syndrome	YAOS Susceptibility To Yao Syndrome Naid Nod2-Associated Aid Nod2-Associated Autoinflammatory Disease
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Intestinal Tuberculosis	Tuberculosis Of Intestine Tuberculosis Of Intestines
Gastroduodenal Crohn'S Disease	Upper Gi Crohn'S Disease
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Diabetes Mellitus	Diabetes
Familial Mediterranean Fever	FMF Benign Paroxysmal Peritonitis Periodic Disease Periodic Fever Syndrome Recurrent Polyserositis Familial Paroxysmal Polyserositis Periodic Fever Familial Mediterranean Fever, Autosomal Recessive Familial Mediterranean Fever, Ar Polyserositis, Recurrent Polyserositis, Familial Paroxysmal Periodic Peritonitis Mef Reimann Periodic Disease Siegal-Cattan-Mamou Disease Wolff Periodic Disease Benign Recurrent Polyserositis Mediterranean Fever, Familial ARFMF Autosomal Recessive Familial Mediterranean Fever Fever, Mediterranean, Familial, Autosomal Recessive Hereditary Autoinflammatory Diseases Fmf - [Familial Mediterranean Fever] Periodic Polyserositis Periodic Familial Polyserositis Periodic Familial Peritonitis Paroxysmal Polyserositis Hereditary Amyloid Nephropathy Familial Recurrent Polyserositis Familial Non-Neuropathic Amyloidosis Armenian Disease Riemann Periodic Disease Siegal Cattan Mamou Disease
Blau Syndrome	Arthrocutaneouveal Granulomatosis Jabs Syndrome BLAUS Sarcoidosis, Early-Onset Acug Granulomatous Inflammatory Arthritis, Dermatitis, And Uveitis, Familial Eos Granulomatosis, Familial Juvenile Systemic Granulomatosis, Familial, Blau Type Familial Juvenile Systemic Granulomatosis Early Onset Sarcoidosis Synovitis Granulomatous With Uveitis And Cranial Neuropathies Early-Onset Sarcoidosis Familial Granulomatosis, Blau Type Pediatric Granulomatous Arthritis Familial Granulomatosis Blau Type Familial Granulomatous Inflammatory Arthritis Dermatitis And Uveitis Synovitis, Granulomatous, With Uveitis And Cranial Neuropathies
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive
Gastrointestinal Tuberculosis	Tuberculosis Of Intestines, Peritoneum And Mesenteric Glands Tuberculosis, Gastrointestinal Tuberculosis Of Gastrointestinal Tract Tuberculosis Of Intestines, Peritoneum, And Mesenteric Glands
Inflammatory Bowel Disease 2	IBD2
Rectal Disease	Rectal Diseases Rectal Disorders
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Inflammatory Bowel Disease 24	IBD24
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Intestinal Perforation	Perforation Of Intestine
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Anorectal Stricture	Stenosis Of Rectum And Anus Anorectal Malformations
Inflammatory Bowel Disease 7	IBD7
Salmonellosis	Salmonella Infections Salmonella Infection
Lymphoproliferative Syndrome, X-Linked, 2	XLP2 Xiap Deficiency X-Linked Lymphoproliferative Syndrome 2 X-Linked Lymphoproliferative Disease Due To Xiap Deficiency Xiap-Related Lymphoproliferative Disease, X-Linked X-Linked Lymphoproliferative Syndrome Type 2 Xiap Deficiency Syndrome
Autoimmune Disease Of Gastrointestinal Tract
Q Fever	Infection Due To Coxiella Burnetii Quadrilateral Fever Query Fever Nine Mile Fever Coxiella Burnetii Fever Q Fever Pneumonia Coxiellosis Pneumonia In Q Fever Australian Q Fever Balkan Grippe
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Anaerobic Meningitis
Mevalonic Aciduria	Mevalonate Kinase Deficiency Mevalonicaciduria Hyperimmunoglobulin D With Periodic Fever MEVA Complete Mevalonate Kinase Deficiency Mva Hyperimmunoglobulinemia D Hyper Igd Syndrome Periodic Fever, Dutch Type Mkd Aciduria, Mevalonic Deficiency Of Mevalonate Kinase
Spondylitis
Pyoderma Gangrenosum	Phagedenic Pyoderma Phagedena Geometric
Inflammatory Bowel Disease 6	IBD6
Arthropathy	Ankylosis Of Ankle And Foot Joint Ankylosis Of Forearm Joint Ankylosis Of Hand Joint Ankylosis Of Joint Of Ankle And/Or Foot Ankylosis Of Joint Of Forearm Ankylosis Of Joint Of Hand Ankylosis Of Joint Of Lower Leg Ankylosis Of Joint Of Multiple Sites Ankylosis Of Joint Of Pelvic Region And Thigh Ankylosis Of Joint Of Shoulder Region Ankylosis Of Joint Of Upper Arm Ankylosis Of Lower Leg Joint Ankylosis Of Multiple Joints Ankylosis Of Upper Arm Joint Infectious Arthropathy Joint Ankylosis Of The Ankle And Foot Joint Ankylosis Of The Ankle And/Or Foot Joint Ankylosis Of The Forearm Joint Ankylosis Of The Hand Joint Ankylosis Of The Lower Leg Joint Ankylosis Of The Pelvic Region And Thigh Joint Ankylosis Of The Shoulder Region Joint Ankylosis Of The Upper Arm Joint Diseases Joint Disease Arthropathy Associated With Infection
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Uveitis
Panuveitis	Diffuse Uveitis Total Uveitis Inflammation Of The Whole Uveal Tract
Autoinflammatory Syndrome
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Colitis
Sapho Syndrome	Acquired Hyperostosis Syndrome Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome Synovitis Acne Pustulosis Hyperostosis Osteitis Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome Pustulo-Psoriatic Hyperostotic Spondylarthritis Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Chemical Colitis
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Acquired Hypogammaglobulinemia Common Variable Immune Deficiency Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Pouchitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Chorioretinitis	Retinochoroiditis
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Ileocolitis	Iieocolitis
Psoriasis
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Aggressive Periodontitis	Juvenile Periodontitis Periodontitis, Juvenile Prepubertal Periodontitis
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Inflammatory Bowel Disease 18	IBD18
Ileitis	Crohn'S Ileitis
Uveal Disease	Uveal Diseases
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Hidradenitis Suppurativa	Acne Inversa Suppurative Hidradenitis Acne Inversa, Familial Apocrinitis Hidradenitides, Suppurative Hidradenitis, Suppurative Suppurative Hidradenitides Inverse Acne
Inflammatory Bowel Disease 9	IBD9
Erythema Nodosum
Muckle-Wells Syndrome	MWS Urticaria-Deafness-Amyloidosis Syndrome Uda Syndrome Neutrophilic Urticaria Urticaria, Deafness And Amyloidosis Cryopyrin-Associated Periodic Syndrome 2 Caps2 Muckle Wells Syndrome Urticaria-Deafness-Amyloidosis Cryopyrin-Associated Periodic Syndromes
Granulomatous Dermatitis
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Colonic Disease	Colonic Diseases Colon Disorder
Hidradenitis	Hydradenitis
Osteomyelitis
Tendinitis	Tendinopathy
Periodic Fever, Familial, Autosomal Dominant	Familial Hibernian Fever Tumor Necrosis Factor Receptor-Associated Periodic Syndrome Traps FPF Tnf Receptor-Associated Periodic Fever Syndrome Hibernian Fever, Familial Fhf Tnf Receptor-Associated Periodic Syndrome Autosomal Dominant Familial Periodic Fever Periodic Fever, Familial Tnf Receptor 1-Associated Periodic Syndrome Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome Familial Periodic Fever Traps Syndrome Tnf Receptor Associated Periodic Syndrome Caledonian Fever Fever, Periodic, Familial Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Melkersson-Rosenthal Syndrome	Melkersson Syndrome Mros Mrs Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal Melkersson'S Syndrome Cheilitis Granulomatosa Granulomatous Cheilitis
Primary Bacterial Infectious Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Abdominal Tuberculosis
Autoinflammation, Panniculitis, And Dermatosis Syndrome	Otulipenia Otulin-Related Autoinflammatory Syndrome AIPDS Oras Infantile-Onset Periodic Fever-Panniculitis-Dermatosis Syndrome Autoinflammation, Panniculitis And Dermatosis Syndrome Otulin Deficiency
Inflammatory Bowel Disease 5	IBD5
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Inflammatory Bowel Disease 3	IBD3
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Chronic Adenitis Acute Adenitis Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Tenosynovitis	Inflammation Of Tendon Sheath Synovitis Or Tenosynovitis
Chronic Recurrent Multifocal Osteomyelitis	Chronic Multifocal Osteomyelitis CRMO Cmo Cno/Crmo Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Osteomyelitis, Chronic Multifocal Multifocal Osteomyelitis, Chronic Chronic Osteomyelitis Chronic Multifocal Osteomyelitis, Unspecified Site Crmo - [Chronic Multifocal Osteomyelitis] Chronic Osteomyelitis With Draining Sinus, Unspecified Site Bone Fistula With Chronic Osteomyelitis
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Cholangitis	Acute Cholangiolitis Ascending Cholangitis Cholangiolitis Cholangitis Nos Chronic Cholangiolitis Hepatic Duct Inflammation Acute Cholangitis Bile Duct Inflammation
Sigmoid Disease	Sigmoid Diseases
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Enteritis, Granulomatous Crohn'S Disease Of Colon Granulomatous Colitis Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Enteritis Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Crohn'S Colitis	Crohn Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-13682	Mifamurtide	99.58%	Unkown
HY-13682B	Mifamurtide sodium	99.92%	Unkown
HY-13682C	Mifamurtide TFA	98.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100691	NOD-IN-1	Inhibitor	99.48%	Unkown
HY-147506	NOD2 antagonist 1	Antagonist	99.57%	Unkown
HY-168159	TLR7 agonist 27	Agonist	/	Unkown
HY-168024	NOD1/2-IN-1	Inhibitor	/	Unkown
HY-146034	NOD1/2 antagonist-1	Antagonist	/	Unkown
HY-179009	NOD2 agonist 4	Agonist	/	Unkown
HY-163274	NOD1 antagonist-1	Antagonist	/	Unkown
HY-176837	NOD2/TLR4 agonist-1	Agonist	/	Unkown
HY-175348	XB2M54	Inhibitor	/	Unkown
HY-101927	NOD1/2 antagonist-2	Antagonist	/	Unkown
HY-123925	CSLP43	Inhibitor	/	Unkown
HY-168158	NOD2 agonist 3	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NOD2	VGNC	VGNC:67682
Macaca mulatta	NOD2	VGNC	VGNC:75297
Mus musculus	NOD2	MGD	MGI:2429397
Canis familiaris	NOD2	VGNC	VGNC:43878
Bos taurus	NOD2	VGNC	VGNC:32151
Rattus norvegicus	NOD2	RGD	RGD:1306368
Others	NOD2	NCBI