1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. NOD-IN-1

NOD-IN-1 

Cat. No.: HY-100691 Purity: 99.60%
Handling Instructions

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

For research use only. We do not sell to patients.

NOD-IN-1 Chemical Structure

NOD-IN-1 Chemical Structure

CAS No. : 132819-92-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 163 In-stock
Estimated Time of Arrival: December 31
1 mg USD 108 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    NOD-IN-1 purchased from MCE. Usage Cited in: Front Cell Infect Microbiol. 2020 May.

    The western blotting shows that the protein levels of NLRP3, caspase-1, GSDMD, IL-1β, IL-18 are decreased in NOD-IN-1 group compared with H3 group.

    NOD-IN-1 purchased from MCE. Usage Cited in: J Hazard Mater. 2020 Jul.

    Under the condition of DBP and DEHP exposure alone, the protein levels of Bax and Caspase9 are significantly increased, and the increased levels are more significantly after DBP and DEHP exposure together. But, in DBP + NOD2- group, DEHP + NOD2- group and DBP + DEHP + NOD2- group, the increase levels of Bax and Caspase9 have been significantly alleviated, respectively.
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    Description

    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

    IC50 & Target

    IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)[1]

    In Vitro

    NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets[1].

    Molecular Weight

    343.40

    Formula

    C₁₈H₁₇NO₄S

    CAS No.

    132819-92-2

    SMILES

    O=S(N1C(C(OCC)=O)=CC2=CC=CC=C21)(C3=CC=C(C)C=C3)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (291.21 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9121 mL 14.5603 mL 29.1206 mL
    5 mM 0.5824 mL 2.9121 mL 5.8241 mL
    10 mM 0.2912 mL 1.4560 mL 2.9121 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.28 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Cell Assay
    [1]

    An MTS assay in which the proliferation rates of HEK-Blue NOD1 cells are measured in the presence of Noditinib-1 and of the synthesized potential NOD1 inhibitor NOD-IN-1 is employed to screen these compounds for potential cytotoxicity. Cells are treated for 24 h with the compound of interest at concentrations of up to 25 μM. Comparison of the resulting metabolic activities with that of the untreated control showed that all compounds are well tolerated by HEK-Blue NOD1 cells, since their residual metabolic activities do not fall below 80% at the maximum concentration tested[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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    Keywords:

    NOD-IN-1NOD-like Receptor (NLR)Inhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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