1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. Mifamurtide

Mifamurtide (Synonyms: MTP-PE; L-MTP-PE; CGP 19835)

Cat. No.: HY-13682 Purity: >99.0%
Handling Instructions

Mifamurtide (MTP-PE; CGP19835) is a drug against osteosarcoma.

For research use only. We do not sell to patients.

Mifamurtide Chemical Structure

Mifamurtide Chemical Structure

CAS No. : 83461-56-7

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1 mg USD 1200 Ask For Quote & Lead Time
5 mg USD 1900 Ask For Quote & Lead Time
10 mg USD 2800 Ask For Quote & Lead Time

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Description

Mifamurtide (MTP-PE; CGP19835) is a drug against osteosarcoma. Mifamurtide is an immunomodulator with antitumor effects that appear to be mediated via activation of monocytes and macrophages. Mifamurtide is generally well tolerated; adverse events attributed to administration of the drug include chills, fever, headache, nausea, and myalgias. Based on the available data, mifamurtide can be considered for inclusion in treatment protocols for localized osteosarcoma [1]. Mifamurtide has orphan drug status for the treatment of osteosarcoma in the US and EU [2].

Clinical Trial
Molecular Weight

1237.50

Formula

C₅₉H₁₀₉N₆O₁₉P

CAS No.

83461-56-7

SMILES

CCCCCCCCCCCCCCCC(OC[[email protected]@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC([[email protected]@H](NC(CC[[email protected]@H](NC([[email protected]@H](NC([[email protected]](O[[email protected]]([[email protected]](O)[[email protected]](O)CO)([H])[[email protected]@H](NC(C)=O)C=O)C)=O)C)=O)C(N)=O)=O)C)=O)(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (80.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8081 mL 4.0404 mL 8.0808 mL
5 mM 0.1616 mL 0.8081 mL 1.6162 mL
10 mM 0.0808 mL 0.4040 mL 0.8081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

MifamurtideMTP-PE L-MTP-PE CGP 19835CGP19835CGP 19835CGP-19835TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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Mifamurtide
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