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Mifamurtide TFA (Synonyms: MTP-PE TFA; L-MTP-PE TFA; CGP 19835 TFA)

Cat. No.: HY-13682C
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Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA, an orphan drug, is a specific ligand of NOD2 used as an insulin sensitizer. Mifamurtide TFA has the potential for osteosarcoma research.

For research use only. We do not sell to patients.

Mifamurtide TFA Chemical Structure

Mifamurtide TFA Chemical Structure

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Description

Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA, an orphan drug, is a specific ligand of NOD2 used as an insulin sensitizer. Mifamurtide TFA has the potential for osteosarcoma research[1][2][3].

In Vitro

Mifamurtide TFA (MTP-PE TFA; 100 µM) induces a reduction of MG63 cells number when co-cultured with macrophages[3].
Mifamurtide TFA (100 µM) increases both the M1 polarization marker iNOS and the M2 polarization marker CD206 mRNAs; both pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines. Mifamurtide TFA increases the iron transporter DMT1 protein[3].
L-mifamurtide TFA (5, 5000 nM; for 48 hours) alone has no direct effect on the proliferation rate of the two osteosarcoma cell lines MOS-J and KHOS in vitro or in vivo[1].
Mifamurtide TFA acts as a nonspecific immunomodulator by activating macrophages and monocytes related to the upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines including tumor necrosis factor (TNF)-a, interleukin (IL)-1, IL-6, IL-8, IL-12, nitric oxide (NO), prostaglandin E2 (PGE2) and PGD2[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mifamurtide TFA (MTP-PE TFA; 1 mg/kg; i.v.; twice per week for 4 weeks) causes a trend of diminished spontaneous lung metastasis dissemination[1].
Mifamurtide TFA (50 μg/mouse) improves glucose tolerance during endotoxemia in mice. Mifamurtide TFA (equivalent to 20 μg MDP; 4 times per week for 5 weeks) improves glucose tolerance in HFD-fed mice without altering body mass[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, BALB/c mice with KHOS osteosarcoma cells[1]
Dosage: 1 mg/kg
Administration: IV; twice per week for 4 weeks
Result: Caused a trend of diminished spontaneous lung metastasis dissemination in xenogeneic (KHOS) and syngeneic (MOS-J) models.
Clinical Trial
Molecular Weight

1351.52

Formula

C₆₁H₁₁₀F₃N₆O₂₁P

SMILES

CCCCCCCCCCCCCCCC(OC[[email protected]@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC([[email protected]@H](NC(CC[[email protected]@H](NC([[email protected]@H](NC([[email protected]](O[[email protected]]([[email protected]](O)[[email protected]](O)CO)([H])[[email protected]@H](NC(C)=O)C=O)C)=O)C)=O)C(N)=O)=O)C)=O)(O)=O)=O.OC(C(F)(F)F)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MifamurtideMTP-PEL-MTP-PECGP 19835CGP19835CGP-19835OthersmuramyldipeptideMDPmacrophagesmonocytesorphanNOD2insulinosteosarcomaTNFIL-1IL-6IL-8IL-12Inhibitorinhibitorinhibit

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Mifamurtide TFA
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