NOD2 antagonist 1
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- Pureté : 99.57%
- CAS No.: 2411441-54-6
- Formule: C26H26N4O3S
- Masse moléculaire:474.57
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
NOD2 5.23 μM (IC50) |
NOD1 28.2 μM (IC50) |
IL-6 |
IL-8 |
IL-10 |
TNF-α |
In Vitro
NOD2 antagonist 1 (compound 32) (0.3125-20 μM; 1 h preincubation before 18 h agonist stimulation) potently and moderately selectively inhibits NOD2-mediated NF-κB transcriptional activity in HEK-Blue NOD2 cells with an IC50 of 5.23 μM, and inhibits NOD1-mediated activity in HEK-Blue NOD1 cells with an IC50 of 28.2 μM[1].
NOD2 antagonist 1 (20 μM; 18 h) is non-cytotoxic to NOD2 and NOD1 cells[1].
NOD2 antagonist 1 (20 μM; 1 h preincubation before 20 h agonist stimulation) significantly inhibits MDP-induced IL-8 release in THP-1 cells at 20 μM, and moderately reduces C12-iE-DAP-induced IL-8 release in the same cell line[1].
NOD2 antagonist 1 (20 μM; 1 h preincubation before 20 h dual agonist stimulation) potently blocks NOD2/TLR4 cross-talk-induced TNF-α release in THP-1 cells at 20 μM, and only weakly inhibits NOD1/TLR4 cross-talk-induced TNF-α release in the same cell line[1].
NOD2 antagonist 1 (20 μM; 1 h preincubation before 18 h agonist stimulation) inhibits NOD2-mediated IL-6, IL-10, and TNF-α release in human primary PBMCs at 20 μM, without affecting T lymphocyte-derived cytokine release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human leukemia monocytic THP-1 cells
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Concentration:20 μM
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Incubation Time:1 h preincubation before 20 h agonist stimulation
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Result:Significantly suppressed MDP-induced IL-8 release in THP-1 cells, with inhibitory activity similar to the positive control GSK669.
Reduced C12-iE-DAP-induced IL-8 release, though to a lesser extent than the positive control noditinib-1.
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Cell Line:human leukemia monocytic THP-1 cells
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Concentration:20 μM
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Incubation Time:1 h preincubation before 20 h dual agonist stimulation
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Result:Markedly suppressed TNF-α release from THP-1 cells stimulated with MDP plus LPS, reducing levels to those induced by LPS alone.
Only slightly decreased TNF-α release from cells stimulated with C12-iE-DAP plus LPS.
Chemical Information
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CAS No. 2411441-54-6
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Appearance Solid
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Masse moléculaire 474.57
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Formule C26H26N4O3S
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Color White to off-white
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SMILES
O=C(NC1=CC2=C(CCC2)C=C1)CN3C4=CC=CC=C4N=C3CCNS(=O)(C5=CC=CC=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 35.71 mg/mL (75.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1072 mL | 10.5359 mL | 21.0717 mL | 52.6793 mL |
| 5 mM | 0.4214 mL | 2.1072 mL | 4.2143 mL | 10.5359 mL | |
| 10 mM | 0.2107 mL | 1.0536 mL | 2.1072 mL | 5.2679 mL | |
| 15 mM | 0.1405 mL | 0.7024 mL | 1.4048 mL | 3.5120 mL | |
| 20 mM | 0.1054 mL | 0.5268 mL | 1.0536 mL | 2.6340 mL | |
| 25 mM | 0.0843 mL | 0.4214 mL | 0.8429 mL | 2.1072 mL | |
| 30 mM | 0.0702 mL | 0.3512 mL | 0.7024 mL | 1.7560 mL | |
| 40 mM | 0.0527 mL | 0.2634 mL | 0.5268 mL | 1.3170 mL | |
| 50 mM | 0.0421 mL | 0.2107 mL | 0.4214 mL | 1.0536 mL | |
| 60 mM | 0.0351 mL | 0.1756 mL | 0.3512 mL | 0.8780 mL |
NOD2 antagonist 1 Related Classifications
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