1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. Dapansutrile

Dapansutrile (Synonyms: OLT1177)

Cat. No.: HY-17629 Purity: >98.0%
Handling Instructions

Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity.

For research use only. We do not sell to patients.

Dapansutrile Chemical Structure

Dapansutrile Chemical Structure

CAS No. : 54863-37-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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  • Technical Information

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Description

Dapansutrile (OLT1177) is a potent, selective and orally active inhibitor of NLRP3 inflammasome. Anti-inflammatory, analgesic activity[1].

IC50 & Target

NLRP3 inflammasome[1]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (938.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5092 mL 37.5460 mL 75.0920 mL
5 mM 1.5018 mL 7.5092 mL 15.0184 mL
10 mM 0.7509 mL 3.7546 mL 7.5092 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (15.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (15.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (15.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

133.17

Formula

C₄H₇NO₂S

CAS No.

54863-37-5

SMILES

N#CCCS(=O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Dapansutrile
Cat. No.:
HY-17629
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Dapansutrile

Cat. No.: HY-17629