54863-37-5
54863-37-5
Chemical Structure
Dapansutrile
- CAS No.: 54863-37-5
- Formula:C4H7NO2S
- Molecular Weight:133.17
IUPAC Name: 3-(methylsulfonyl)propanenitrile
InChIKey: LQFRYKBDZNPJSW-UHFFFAOYSA-N
SMILES: N#CCCS(=O)(C)=O
Biological Activity: Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases[1][2].
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Dapansutrile | 99.92% | Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases. | ||||||||||||||||||||
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Dapansutrile (Standard) | ≥98% | Dapansutrile (Standard) is the analytical standard of Dapansutrile. This product is intended for research and analytical applications. Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases. | ||||||||||||||||||||
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References
- [1]. Sánchez-Fernández A, et, al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Immunol. 2019 Nov 1;10:2578. [Content Brief]
- [2]. Toldo S, et, al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73(4):215-222. [Content Brief]
Keywords
