Isethionic acid (80% in water)  (Synonyms: 2-Hydroxyethanesulfonic acid)

Isethionic acid is a calcium binder and anionic detergent that enhances mitochondrial calcium binding capacity by competitively binding to calcium binding sites on the outer mitochondrial membrane. Isethionic acid can inhibit calcium-activated mitochondrial respiration. Isethionic acid inhibits barnacle (Balanus amphitrite) larvae with LC₅₀s of 23 μg/mL (24 h) and 17 μg/mL (48 h), respectively. Isethionic acid can inhibit the attachment of barnacle larvae (complete inhibition at 10 μg/mL) and regulate mitochondrial calcium transport, and can enhance ATP-dependent calcium uptake at high calcium concentrations. Isethionic acid can be used to study the mechanism of mitochondrial calcium metabolism.

Isethionic acid (3×10^-5-6×10^-4; 30 min) inhibits 4 mM CaCl₂-activated respiration in rat liver mitochondrial respiration assay, with a maximum inhibition rate of 85% (6×10^-4 M), and does not affect phosphate production^[2].
Isethionic acid (3×10^-4 M; 1 min) increases calcium uptake under 10 mM Ca²⁺ conditions in an ATP-dependent calcium uptake assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

126.13

C₂H₆O₄S

107-36-8

Liquid

Colorless to light yellow

O=S(CCO)(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Hellio C, et al. Isethionic acid and floridoside isolated from the red alga, Grateloupia turuturu, inhibit settlement of Balanus amphitrite cyprid larvae. Biofouling. 2004 Jun;20(3):139-45.  [Content Brief]

  [2]. Dolara P, et al. Effect of 2-aminoethanesulphinic acid (taurine) and 2-hydroxyethane sulphonic acid (isethionic acid) on calcium transport by rat liver mitochondria. Biochem Pharmacol. 1973 Sep 1;22(17):2085-94.  [Content Brief]