1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. JC124

JC124 

Cat. No.: HY-120007
Handling Instructions

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.

For research use only. We do not sell to patients.

JC124 Chemical Structure

JC124 Chemical Structure

CAS No. : 1638611-48-9

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Description

JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1].

In Vitro

JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI)[1]
Dosage: 100 mg/kg
Administration: i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI
Result: Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.
Molecular Weight

382.86

Formula

C₁₇H₁₉ClN₂O₄S

CAS No.
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JC124
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