1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. Nodinitib-1

Nodinitib-1 (Synonyms: ML130; CID-1088438)

Cat. No.: HY-18639 Purity: >98.0%
Handling Instructions

Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.

For research use only. We do not sell to patients.

Nodinitib-1 Chemical Structure

Nodinitib-1 Chemical Structure

CAS No. : 799264-47-4

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 84 In-stock
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25 mg USD 168 In-stock
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50 mg USD 276 In-stock
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100 mg USD 492 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC50 of 0.56 μM.

IC50 & Target

IC50: 0.56 μM (NOD1)[1]

In Vitro

Nodinitib-1 selectively inhibits IL-8 production induced by NOD1 ligand. Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity[1]. Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay[2].

Molecular Weight

287.34

Formula

C₁₄H₁₃N₃O₂S

CAS No.

799264-47-4

SMILES

NC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (69.60 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4802 mL 17.4010 mL 34.8020 mL
5 mM 0.6960 mL 3.4802 mL 6.9604 mL
10 mM 0.3480 mL 1.7401 mL 3.4802 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

RAW264.7 cells are treated with 5 μM of CID-1088438 or CID-44229067 alone, or also infected with S. typhimurium at multiplicity of infection (MOI) of 20 and 200 bacteria per mammalian cell. Cell viability is analyzed two hours after Salmonella infection by measuring ATP levels. Percentage viability is calculated according to the ATP levels of respective non-infected cells. Values presented are averages of two replicates (+ SEM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Nodinitib-1
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