2. Gene
  3. PPP2R5E - protein phosphatase 2 regulatory subunit B'epsilon Gene

PPP2R5E - protein phosphatase 2 regulatory subunit B'epsilon Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B56E; B56epsilon

Gene ID: 5529 | Gene type: protein coding

About PPP2R5E

Cytogenetic location: 14q23.2 Genomic coordinates (GRCh38): 14:63,371,364-63,543,377 (from NCBI)

This gene has 7 transcripts (splice variants), 225 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 11.5), colon (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

PPP2R5E Products(6)

mRNA Protein Name
NM_001282179.3 NP_001269108.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a
NM_001282180.3 NP_001269109.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform b
NM_001282181.3 NP_001269110.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c
NM_001282182.3 NP_001269111.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c
NM_001354926.2 NP_001341855.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform d
NM_006246.5 NP_006237.1 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a

PPP2R5E Protein Structure

B56

B56: Protein phosphatase 2A regulatory B subunit (B56 family) (47 - 453)

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  • 467 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

PP2A, B subunit, B' epsilon

Related Diseases

Diseases Alias
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11022 PPP2R5E Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP2R5E VGNC VGNC:104608
Canis familiaris PPP2R5E VGNC VGNC:44917
Rattus norvegicus PPP2R5E RGD RGD:1305657
Macaca mulatta PPP2R5E VGNC VGNC:76381
Mus musculus PPP2R5E MGD MGI:1349473
Bos taurus PPP2R5E VGNC VGNC:33264