PPP2R5E - protein phosphatase 2 regulatory subunit B'epsilon Gene
Also Known as B56E; B56epsilon
Species: Homo sapiens
About PPP2R5E
This gene has 7 transcripts (splice variants), 225 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 11.5), colon (RPKM 9.9) and 25 other tissues.
Summary
The protein encoded by this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
PPP2R5E Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001282179.3 | NP_001269108.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a |
| NM_001282180.3 | NP_001269109.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform b |
| NM_001282181.3 | NP_001269110.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c |
| NM_001282182.3 | NP_001269111.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform c |
| NM_001354926.2 | NP_001341855.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform d |
| NM_006246.5 | NP_006237.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15380617 | GOA |
PPP2R5E Protein Structure
B56: Protein phosphatase 2A regulatory B subunit (B56 family) (47 - 453)
- 0
- 100
- 200
- 300
- 400
- 467 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform |
|
PPP2R5E Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP2R5E | Q16537 | CHEK2 | Homo sapiens | O96017 | 15380617 | |
|
Intra
|
PPP2R5E | Q16537 | PPP2R1A | Homo sapiens | P30153 | 23555304 | |
|
Intra
|
PPP2R5E | Q16537 | PPP2R1B | Homo sapiens | P30154 | 23555304 | |
|
Intra
|
PPP2R5E | Q16537 | ZDHHC17 | Homo sapiens | Q8IUH5 | 24705354 | |
|
Intra
|
PPP2R5E | Q16537 | ZDHHC17 | Homo sapiens | Q8IUH5 | 24705354 | |
|
Intra
|
PPP2R5E | Q16537 | RACGAP1 | Homo sapiens | Q9H0H5 | 18201571 | |
|
Intra
|
PPP2R5E | Q16537 | RACGAP1 | Homo sapiens | Q9H0H5 | 18201571 | |
|
Intra
|
PPP2R5E | Q16537 | RACGAP1 | Homo sapiens | Q9H0H5 | 18201571 | |
|
Intra
|
PPP2R5E | Q16537 | DZIP1 | Homo sapiens | Q86YF9 | 21878643 |
PPP2R5E Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81963 | PPP2R5E Antibody (YA1708) | WB, IHC-F, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P81963A | PPP2R5E Antibody (YA1708)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cornelia De Lange Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | PPP2R5E | VGNC | VGNC:104608 |
| Canis familiaris | PPP2R5E | VGNC | VGNC:44917 |
| Rattus norvegicus | PPP2R5E | RGD | RGD:1305657 |
| Macaca mulatta | PPP2R5E | VGNC | VGNC:76381 |
| Mus musculus | PPP2R5E | MGD | MGI:1349473 |
| Bos taurus | PPP2R5E | VGNC | VGNC:33264 |
| Others | PPP2R5E | NCBI |