PPP2R1B - protein phosphatase 2 scaffold subunit Abeta Gene

Also Known as PR65B; PP2A-Abeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5519

About PPP2R1B

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,688,000-111,766,389 (from NCBI)

This gene has 12 transcripts (splice variants), 192 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a constant regulatory subunit of protein Phosphatase 2. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R1B Products (5)

mRNA	Protein	Name
NM_001177562.2	NP_001171033.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d
NM_001177563.2	NP_001171034.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e
NM_002716.5	NP_002707.3	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a
NM_181699.3	NP_859050.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b
NM_181700.2	NP_859051.1	serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8392071	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	21172653	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	21172653	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane raft	IDA IDA: Inferred from direct assay	21172653	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R1B Protein Structure

HEAT

HEAT_2

0
100
200
300
400
500
601 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform	protein phosphatase 2, regulatory subunit A, beta

PPP2R1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R1B	P30154	RALA	Homo sapiens	P11233	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R2A	Homo sapiens	P63151	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R5C	Homo sapiens	Q13362	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2R5C	Homo sapiens	Q13362	Pull Down	16456541
Intra	PPP2R1B	P30154	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R1B	P30154	PPP2R5D	Homo sapiens	Q14738	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	17540176
Intra	PPP2R1B	P30154	PPP2CA	Homo sapiens	P67775	Chromatography	8392071
Intra	PPP2R1B	P30154	PPP2R5E	Homo sapiens	Q16537	Anti Tag CoIP	17540176
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	Anti Bait CoIP	21172653
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	GMS	21172653
Cross	PPP2R1B	P30154	Unc5b	Rattus norvegicus	O08722	Anti Tag CoIP	21172653

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Hereditary Wilms' Tumor	Hereditary Wilms Tumor Hereditary Wilms Tumour Hereditary Wilms' Tumour Wt1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11010	PPP2R1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22018	Ppp2r1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28536	Ppp2r1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP2R1B	MGD	MGI:1920949
Rattus norvegicus	PPP2R1B	RGD	RGD:1304764
Macaca mulatta	PPP2R1B	VGNC	VGNC:76375
Felis catus	PPP2R1B	VGNC	VGNC:69010
Bos taurus	PPP2R1B	VGNC	VGNC:33254
Canis familiaris	PPP2R1B	VGNC	VGNC:44906
Others	PPP2R1B	NCBI