PPP2CA - protein phosphatase 2 catalytic subunit alpha Gene

Also Known as RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5515

About PPP2CA

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,194,332-134,226,073 (from NCBI)

This gene has 12 transcripts (splice variants), 287 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 63.8), bone marrow (RPKM 57.1) and 25 other tissues.

Summary

This gene encodes the Phosphatase 2A catalytic subunit. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

PPP2CA Products (4)

mRNA Protein Name
NM_001355019.2 NP_001341948.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4 NP_002706.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1
NM_001355019.2 NP_001341948.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 2
NM_002715.4 NP_002706.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
1328865 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
9847399 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
25438055 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
15525651 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20080667 GOA
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
33633399 GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21806946 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
30611118 GOA
involved in peptidyl-threonine dephosphorylation IMP
IMP: Inferred from mutant phenotype
15525651 GOA
involved in positive regulation of protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
20080667 GOA
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
33108758 GOA
involved in regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
25438055 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
29063833 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
16258073 GOA
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
17055435 GOA
part of protein serine/threonine phosphatase complex IDA
IDA: Inferred from direct assay
29063833 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2CA Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (51 - 243)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

  • PP2A-alpha

PPP2CA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP2CA P67775 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 STRN Homo sapiens O43815
TAP
18782753
Intra
PPP2CA P67775 STRN Homo sapiens O43815
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 STRN Homo sapiens O43815
Pull Down
28330616
Intra
PPP2CA P67775 STRN Homo sapiens O43815
Anti Tag CoIP
26496610
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Y2H
21988832
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
27880917
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
26496610
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Y2H
9647778
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Bait CoIP
23892082
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Validated Y2H
32296183
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Y2H Array
32296183
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
TAP
18782753
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
19156129
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
BioID
28330616
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Pull Down
28330616
Intra
PPP2CA P67775 IGBP1 Homo sapiens P78318
Anti Tag CoIP
9647778
Intra
PPP2CA P67775 CLPP Homo sapiens Q16740
Y2H Array
32296183
Intra
PPP2CA P67775 CLPP Homo sapiens Q16740
Validated Y2H
32296183
Intra
PPP2CA P67775 CLPP Homo sapiens Q16740
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra
PPP2CA P67775 L3MBTL3 Homo sapiens Q96JM7-2
Validated Y2H
32296183
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Y2H
7592815
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
TAP
18782753
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
19156129
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
27880917
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Pull Down
16456541
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Pull Down
28330616
Intra
PPP2CA P67775 PPP2R5C Homo sapiens Q13362
Pull Down
19915589
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
16456541
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
27880917
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
7592815
Intra
PPP2CA P67775 PPP2R5B Homo sapiens Q15173
Pull Down
28330616
Intra
PPP2CA P67775 IER3 Homo sapiens P46695
Anti Tag CoIP
16456541
Intra
PPP2CA P67775 IER3 Homo sapiens P46695
Pull Down
16456541
Intra
PPP2CA P67775 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
Intra
PPP2CA P67775 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Array
32296183
Intra
PPP2CA P67775 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
Pull Down
28330616
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
26496610
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
TAP
18782753
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
19156129
Intra
PPP2CA P67775 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 C3orf36 Homo sapiens Q3SXR2
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 C3orf36 Homo sapiens Q3SXR2
Validated Y2H
32296183
Intra
PPP2CA P67775 C3orf36 Homo sapiens Q3SXR2
Y2H Array
32296183
Intra
PPP2CA P67775 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra
PPP2CA P67775 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 UBAP2 Homo sapiens Q5T6F2
Validated Y2H
32296183
Intra
PPP2CA P67775 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
PPP2CA P67775 AKT1 Homo sapiens P31749
Pull Down
16044149
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Pull Down
19915589
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
18715871
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Pull Down
28330616
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
19915589
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
27880917
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
26496610
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Y2H
8617797
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
TAP
18782753
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
19156129
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 PPP2R1A Homo sapiens P30153
BioID
28330616
Cross
PPP2CA P67775 Nxn Mus musculus P97346
Anti Tag CoIP
16764867
Cross
PPP2CA P67775 Nxn Mus musculus P97346
Pull Down
16764867
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
Anti Tag CoIP
18715871
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
Pull Down
28330616
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
TAP
18782753
Intra
PPP2CA P67775 PPP2R1B Homo sapiens P30154
Anti Tag CoIP
19156129
Intra
PPP2CA P67775 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
PPP2CA P67775 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
PPP2CA P67775 TRIP13 Homo sapiens Q15645
Y2H Pooling
16189514
Intra
PPP2CA P67775 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra
PPP2CA P67775 RAF1 Homo sapiens P04049
Anti Tag CoIP
16239230
Intra
PPP2CA P67775 RAF1 Homo sapiens P04049
Phosphatase Assay
16239230
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
27880917
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Pull Down
28330616
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
26496610
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Y2H
7592815
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
18782753
Intra
PPP2CA P67775 PPP2R5A Homo sapiens Q15172
Anti Tag CoIP
7592815
Cross
PPP2CA P67775 Igbp1 Mus musculus Q61249
Pull Down
12963337
Cross
PPP2CA P67775 Igbp1 Mus musculus Q61249
Competition Binding
12963337
Cross
PPP2CA P67775 E7 Human papillomavirus P04020
Pull Down
16044149
Intra
PPP2CA P67775 IKBKB Homo sapiens O14920
Anti Bait CoIP
16126728
Intra
PPP2CA P67775 IKBKB Homo sapiens O14920
GMS
16126728
Intra
PPP2CA P67775 KISS1R Homo sapiens Q969F8
Y2H
18977201
Cross
PPP2CA P67775 E7 Human papillomavirus P03129
CoIP
16044149
Cross
PPP2CA P67775 E7 Human papillomavirus P03129
Pull Down
16044149
Intra
PPP2CA P67775 RBL2 Homo sapiens Q08999
CoIP
15467457
Intra
PPP2CA P67775 SGO1 Homo sapiens Q5FBB7
Anti Tag CoIP
35271311
Intra
PPP2CA P67775 SGO1 Homo sapiens Q5FBB7
Pull Down
28330616
Intra
PPP2CA P67775 SGO1 Homo sapiens Q5FBB7
Anti Tag CoIP
27880917
Cross: Cross-species interaction Intra: Intraspecies interaction

PPP2CA Antibodies

Cat. No. Product Name Application Reactivity
HY-P80284 PP2A alpha + beta Antibody (YA123) WB, ICC/IF, IHC-P, IP Human, Mouse, Rat
HY-P81948 PP2A alpha/beta Antibody (YA1693) WB, IHC-P, IHC-F, ICC/IF, FC Human, Mouse, Rat
HY-P81948A PP2A alpha/beta Antibody (YA1693)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat, Hamster
HY-P83111 Phospho-PP2A alpha (Tyr307) Antibody (YA2856) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P85454 PP2A alpha Antibody (YA5146) WB, ICC/IF Human, Mouse, Bovine, Chicken, Dog, Pig, Rabbit, Zebrafish
HY-P86411 PP2A alpha/beta Antibody (YA6103) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities

  • NEDLBA
Alzheimer Disease 15

  • AD15

  • Alzheimer'S Disease 15

  • Alzheimer Disease Without Neurofibrillary Tangles

  • Alzheimer'S Disease 15, Late Onset

  • Alzheimer'S Disease Without Neurofibrillary Tangles
Cornelia De Lange Syndrome

  • De Lange Syndrome

  • Brachmann De Lange Syndrome

  • Brachmann-De Lange Syndrome

  • Cdls

  • Bdls

  • Typus Degenerativus Amstelodamensis
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11007 PPP2CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21174 Ppp2ca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27691 Ppp2ca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP2CA VGNC VGNC:33251
Mus musculus PPP2CA MGD MGI:1321159
Felis catus PPP2CA VGNC VGNC:102292
Rattus norvegicus PPP2CA RGD RGD:3380
Others PPP2CA NCBI