PPP2R5B - protein phosphatase 2 regulatory subunit B'beta Gene

Also Known as B56B; PR61B; B56beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5526

About PPP2R5B

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,917,573-64,934,475 (from NCBI)

This gene has 5 transcripts (splice variants), 190 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 15.1), gall bladder (RPKM 6.6) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

PPP2R5B Products (1)

mRNA	Protein	Name
NM_006244.4	NP_006235.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7592815	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R5B Protein Structure

B56

0
100
200
300
400
497 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform	protein phosphatase 2 regulatory subunit B', beta

PPP2R5B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R5B	Q15173	CHEK2	Homo sapiens	O96017	Pull Down	15380617
Intra	PPP2R5B	Q15173	IER3	Homo sapiens	P46695	Anti Tag CoIP	16456541
Intra	PPP2R5B	Q15173	IER3	Homo sapiens	P46695	Pull Down	16456541
Intra	PPP2R5B	Q15173	PPP2R1A	Homo sapiens	P30153	Y2H Prey Pooling	32296183
Intra	PPP2R5B	Q15173	PPP2R1A	Homo sapiens	P30153	Y2H Array	32296183
Intra	PPP2R5B	Q15173	PPP2CA	Homo sapiens	P67775	Y2H	7592815
Intra	PPP2R5B	Q15173	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 30	Spinocerebellar Ataxia Type 30 SCA30 Cerebellar Ataxia Early-Onset Nonprogressive Spinocerebellar Ataxia 29 Acv Aplasia Of Cerebellar Vermis Cerebellar Vermis Aplasia Congenital Nonprogressive Spinocerebellar Ataxia Sca29 Spinocerebellar Ataxia Type 29
Spinocerebellar Ataxia 25	Spinocerebellar Ataxia Type 25 SCA25
Spinocerebellar Ataxia 21	Spinocerebellar Ataxia Type 21 SCA21 Ataxia, Spinocerebellar, Type 21
Spinocerebellar Ataxia 20	Spinocerebellar Ataxia Type 20 SCA20 Spinocerebellar Ataxia With Dysphonia Spinocerebellar Ataxia With Spasmodic Cough Chromosome 11q12 Duplication Syndrome, 260-Kb Chromosome 11q12 Duplication Syndrome 260-Kb
Spinocerebellar Ataxia 12	Spinocerebellar Ataxia Type 12 SCA12 Ataxia, Spinocerebellar, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11019	PPP2R5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP2R5B	VGNC	VGNC:69016
Bos taurus	PPP2R5B	VGNC	VGNC:33261
Rattus norvegicus	PPP2R5B	RGD	RGD:727786
Mus musculus	PPP2R5B	MGD	MGI:2388480
Macaca mulatta	PPP2R5B	VGNC	VGNC:101383
Canis familiaris	PPP2R5B	VGNC	VGNC:44914
Others	PPP2R5B	NCBI