IER3 - immediate early response 3 Gene

Homo sapiens

Also known as DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L

Gene ID: 8870 | Gene type: protein coding

About IER3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,743,199-30,744,547 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 124 orthologues. Ubiquitous expression in bone marrow (RPKM 75.0), urinary bladder (RPKM 74.3) and 25 other tissues.

Summary

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced Apoptosis. Partially degraded and unspliced transcripts are found after virus Infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

IER3 Products(1)

mRNA	Protein	Name
NM_003897.4	NP_003888.2	radiation-inducible immediate-early gene IEX-1

Protein Preferred Names

Protein Names

radiation-inducible immediate-early gene IEX-1

PACAP-responsive gene 1 protein

Related Diseases

Diseases

Alias

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6	CDCBM6
Cdcbm56	Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Dyslexia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06548	IER3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS06549	IER3IP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IER3	VGNC	VGNC:57224
Bos taurus	IER3	VGNC	VGNC:30039
Felis catus	IER3	VGNC	VGNC:67695
Macaca mulatta	IER3	VGNC	VGNC:73560
Mus musculus	IER3	MGD	MGI:104814
Rattus norvegicus	IER3	RGD	RGD:1303321

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