CISD2 - CDGSH iron sulfur domain 2 Gene
Also Known as ERIS; WFS2; ZCD2; NAF-1; Miner1
Species: Homo sapiens
About CISD2
This gene has 5 transcripts (splice variants), 215 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 8.6), kidney (RPKM 5.5) and 25 other tissues.
Summary
The protein encoded by this gene is a Zinc Finger Protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
CISD2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001008388.5 | NP_001008389.1 | CDGSH iron-sulfur domain-containing protein 2 |
CISD2 Protein Structure
MitoNEET_N: Iron-containing outer mitochondrial membrane protein N-terminus (1 - 66)
zf-CDGSH: Iron-binding zinc finger CDGSH type (77 - 115)
- 0
- 100
- 135 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
CDGSH iron-sulfur domain-containing protein 2 |
|
CISD2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CISD2 | Q8N5K1 | SLC35B4 | Homo sapiens | Q969S0 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | PNKP | Homo sapiens | Q96T60 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | CFHR5 | Homo sapiens | Q9BXR6 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | AIG1 | Homo sapiens | Q9NVV5-2 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | C4orf3 | Homo sapiens | Q8WVX3-2 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | NRAC | Homo sapiens | Q8N912 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | PGAP2 | Homo sapiens | Q9UHJ9-5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | FAM241B | Homo sapiens | Q96D05-2 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | MAN2B2 | Homo sapiens | Q9Y2E5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | AQP10 | Homo sapiens | Q96PS8 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | AQP10 | Homo sapiens | Q96PS8 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | TMEM243 | Homo sapiens | Q9BU79 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | SLC13A3 | Homo sapiens | Q8WWT9 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | PLPPR2 | Homo sapiens | Q96GM1 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | POMGNT1 | Homo sapiens | Q8WZA1 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | NAPB | Homo sapiens | Q9H115 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | APOL2 | Homo sapiens | Q9BQE5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | HHATL | Homo sapiens | Q9HCP6 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | CLN6 | Homo sapiens | Q9NWW5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | BCL2L2 | Homo sapiens | Q92843 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | TMEM43 | Homo sapiens | Q9BTV4 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | SERP2 | Homo sapiens | Q8N6R1 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | YIPF6 | Homo sapiens | Q96EC8 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | BCL2 | Homo sapiens | P10415 | 20010695 | |
|
Intra
|
CISD2 | Q8N5K1 | BCL2 | Homo sapiens | P10415 | 20010695 | |
|
Intra
|
CISD2 | Q8N5K1 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | NRG4 | Homo sapiens | Q8WWG1 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | BTN2A2 | Homo sapiens | Q8WVV5 | 32296183 | |
|
Intra
|
CISD2 | Q8N5K1 | SEC22A | Homo sapiens | Q96IW7 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Wolfram Syndrome 2 |
|
|
| Wolfram Syndrome |
|
|
| Wolfram Syndrome 1 |
|
|
| Diabetes Insipidus |
|
|
| Noonan Syndrome 13 |
|
|
| Primary Optic Atrophy |
|
|
| 3-Methylglutaconic Aciduria, Type Iii |
|
|
| Waardenburg Syndrome, Type 1 |
|
|
| Neurogenic Bladder |
|
|
| Waardenburg'S Syndrome |
|
|
| Optic Nerve Disease |
|
|
| Cranial Nerve Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CISD2 | VGNC | VGNC:27372 |
| Felis catus | CISD2 | VGNC | VGNC:78470 |
| Macaca mulatta | CISD2 | VGNC | VGNC:106563 |
| Rattus norvegicus | CISD2 | RGD | RGD:1566242 |
| Mus musculus | CISD2 | MGD | MGI:1914256 |
| Canis familiaris | CISD2 | VGNC | VGNC:39279 |
| Others | CISD2 | NCBI |