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NAPB - NSF attachment protein beta Gene

Also Known as SNAPB; DEE107; SNAP-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63908

About NAPB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,374,522-23,421,488 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 118.1) and adrenal (RPKM 14.6).

Summary

This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA Receptor. [provided by RefSeq, Mar 2017]

NAPB Products (4)

mRNA	Protein	Name
NM_001283018.2	NP_001269947.1	beta-soluble NSF attachment protein isoform a
NM_001283020.2	NP_001269949.1	beta-soluble NSF attachment protein isoform c
NM_001283026.2	NP_001269955.1	beta-soluble NSF attachment protein isoform d
NM_022080.3	NP_071363.1	beta-soluble NSF attachment protein isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPB Protein Structure

SNAP

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
beta-soluble NSF attachment protein	N-ethylmaleimide-sensitive factor attachment protein, beta

NAPB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAPB	Q9H115	SNAP23	Homo sapiens	A8K287	Validated Y2H	25416956
Intra	NAPB	Q9H115	SNAP23	Homo sapiens	A8K287	Y2H Array	25416956
Intra	NAPB	Q9H115	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	NAPB	Q9H115	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	DGAT2L6	Homo sapiens	Q6ZPD8	Y2H Array	32296183
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	32296183
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Validated Y2H	25416956
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	29892012
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Array	31515488
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Prey Pooling	25416956
Intra	NAPB	Q9H115	STX3	Homo sapiens	Q13277	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	NAPB	Q9H115	KCNN3	Homo sapiens	Q9UGI6-2	Validated Y2H	32296183
Intra	NAPB	Q9H115	KCNN3	Homo sapiens	Q9UGI6-2	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	NAPB	Q9H115	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	NAPB	Q9H115	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	STX6	Homo sapiens	O43752	Validated Y2H	25416956
Intra	NAPB	Q9H115	STX6	Homo sapiens	O43752	Y2H	21516116
Intra	NAPB	Q9H115	STX16	Homo sapiens	O14662	Y2H Array	25416956
Intra	NAPB	Q9H115	STX16	Homo sapiens	O14662	Y2H Prey Pooling	25416956
Intra	NAPB	Q9H115	STX16	Homo sapiens	O14662	Validated Y2H	25416956
Intra	NAPB	Q9H115	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	NAPB	Q9H115	ALOX5AP	Homo sapiens	P20292	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	ALOX5AP	Homo sapiens	P20292	Y2H Array	32296183
Intra	NAPB	Q9H115	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	NAPB	Q9H115	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	TFEC	Homo sapiens	O14948	Validated Y2H	25416956
Intra	NAPB	Q9H115	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	SNAP29	Homo sapiens	O95721	Y2H Array	32296183
Intra	NAPB	Q9H115	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	SYT1	Homo sapiens	P21579	Y2H Array	32296183
Intra	NAPB	Q9H115	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	NAPB	Q9H115	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Array	25416956
Intra	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Array	32296183
Intra	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	STX5	Homo sapiens	Q13190	Validated Y2H	25416956
Intra	NAPB	Q9H115	ARL6IP1	Homo sapiens	Q15041	Y2H Prey Pooling	25416956
Intra	NAPB	Q9H115	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	NAPB	Q9H115	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	NAPB	Q9H115	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
Intra	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Validated Y2H	25416956
Intra	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Array	25416956
Intra	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	NAPB	Q9H115	SNAP23	Homo sapiens	O00161	Validated Y2H	25416956
Intra	NAPB	Q9H115	BET1	Homo sapiens	O15155	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	BET1	Homo sapiens	O15155	Y2H Array	32296183
Intra	NAPB	Q9H115	SIGLEC5	Homo sapiens	O15389	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	SIGLEC5	Homo sapiens	O15389	Y2H Array	32296183
Intra	NAPB	Q9H115	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
Intra	NAPB	Q9H115	STX19	Homo sapiens	Q8N4C7	Y2H Array	32296183
Intra	NAPB	Q9H115	STX19	Homo sapiens	Q8N4C7	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	NAPB	Q9H115	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 107	DEE107 Developmental And Epileptic Encephalopathy-107
Amyotrophy, Hereditary Neuralgic	Hereditary Neuralgic Amyotrophy Neuritis With Brachial Predilection HNA Napb Brachial Plexus Neuropathy, Hereditary Hereditary Brachial Plexus Neuropathy Amyotrophy, Hereditary Neuralgic, With Predilection For Brachial Plexus Brachial Neuralgia Brachial Plexus Neuritis Neuralgic Amyotrophy Amyotrophic Neuralgia Brachial Neuritis Familial Brachial Plexus Neuritis Heredofamilial Neuritis With Brachial Plexus Predilection Shoulder Girdle Neuropathy Hereditary Neuralgic Amyotrophy With Predilection For Brachial Plexus Amyotrophy, Neuralgic, Hereditary Acute Brachial Neuritis
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09030	NAPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12685	SEPTIN9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAPB	VGNC	VGNC:43620
Mus musculus	NAPB	MGD	MGI:104562
Felis catus	NAPB	VGNC	VGNC:81129
Macaca mulatta	NAPB	VGNC	VGNC:74963
Bos taurus	NAPB	VGNC	VGNC:31882
Rattus norvegicus	NAPB	RGD	RGD:1589649
Others	NAPB	NCBI