NAPB - NSF attachment protein beta Gene

Homo sapiens

Also known as SNAPB; DEE107; SNAP-BETA

Gene ID: 63908 | Gene type: protein coding

About NAPB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,374,522-23,421,488 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 118.1) and adrenal (RPKM 14.6).

Summary

This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]

NAPB Products(4)

mRNA	Protein	Name
NM_001283018.2	NP_001269947.1	beta-soluble NSF attachment protein isoform a
NM_001283020.2	NP_001269949.1	beta-soluble NSF attachment protein isoform c
NM_001283026.2	NP_001269955.1	beta-soluble NSF attachment protein isoform d
NM_022080.3	NP_071363.1	beta-soluble NSF attachment protein isoform b

NAPB Protein Structure

SNAP

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

beta-soluble NSF attachment protein

N-ethylmaleimide-sensitive factor attachment protein, beta

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 107

DEE107

Developmental And Epileptic Encephalopathy-107

Amyotrophy, Hereditary Neuralgic

Hereditary Neuralgic Amyotrophy	Neuritis With Brachial Predilection
HNA	Napb
Brachial Plexus Neuropathy, Hereditary	Hereditary Brachial Plexus Neuropathy
Amyotrophy, Hereditary Neuralgic, With Predilection For Brachial Plexus	Brachial Neuralgia
Brachial Plexus Neuritis	Neuralgic Amyotrophy
Amyotrophic Neuralgia	Brachial Neuritis
Familial Brachial Plexus Neuritis	Heredofamilial Neuritis With Brachial Plexus Predilection
Shoulder Girdle Neuropathy	Hereditary Neuralgic Amyotrophy With Predilection For Brachial Plexus
Amyotrophy, Neuralgic, Hereditary	Acute Brachial Neuritis

Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder	Obsessive-Compulsive Personality
Compulsive Personality Disorder	Ocpd
Obsessional Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09030	NAPB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NAPB	VGNC	VGNC:43620
Mus musculus	NAPB	MGD	MGI:104562
Felis catus	NAPB	VGNC	VGNC:81129
Macaca mulatta	NAPB	VGNC	VGNC:74963
Bos taurus	NAPB	VGNC	VGNC:31882
Rattus norvegicus	NAPB	RGD	RGD:1589649