BET1 - Bet1 golgi vesicular membrane trafficking protein Gene

Also Known as HBET1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10282

About BET1

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:93,962,762-94,004,355 (from NCBI)

This gene has 8 transcripts (splice variants) and 76 orthologues. Ubiquitous expression in placenta (RPKM 6.4), adrenal (RPKM 5.3) and 25 other tissues.

Summary

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

BET1 Products (2)

mRNA Protein Name
NM_001317739.2 NP_001304668.1 BET1 homolog isoform 2
NM_005868.6 NP_005859.1 BET1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
34779586 GOA
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network IDA
IDA: Inferred from direct assay
34779586 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
34779586 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BET1 Protein Structure

SNARE

SNARE: SNARE domain (31 - 90)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

BET1 homolog

  • Bet1p homolog

BET1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BET1 O15155 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
BET1 O15155 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
BET1 O15155 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
BET1 O15155 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra
BET1 O15155 MAGEA6 Homo sapiens P43360
Validated Y2H
25416956
Intra
BET1 O15155 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
BET1 O15155 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
BET1 O15155 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
BET1 O15155 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra
BET1 O15155 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra
BET1 O15155 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
BET1 O15155 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
BET1 O15155 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMEM35A Homo sapiens Q53FP2
Validated Y2H
32296183
Intra
BET1 O15155 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra
BET1 O15155 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
BET1 O15155 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
BET1 O15155 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
BET1 O15155 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
BET1 O15155 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
BET1 O15155 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
BET1 O15155 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra
BET1 O15155 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
BET1 O15155 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
BET1 O15155 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra
BET1 O15155 CD74 Homo sapiens P04233-2
Validated Y2H
32296183
Intra
BET1 O15155 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
BET1 O15155 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra
BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra
BET1 O15155 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
Intra
BET1 O15155 ASGR2 Homo sapiens P07307-3
Validated Y2H
32296183
Intra
BET1 O15155 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
BET1 O15155 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Prey Pooling
32296183
Intra
BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Validated Y2H
32296183
Intra
BET1 O15155 SLC26A6 Homo sapiens Q9BXS9-3
Y2H Array
32296183
Intra
BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Validated Y2H
32296183
Intra
BET1 O15155 TMCO5A Homo sapiens Q8N6Q1
Y2H Array
32296183
Intra
BET1 O15155 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
BET1 O15155 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
BET1 O15155 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
BET1 O15155 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
BET1 O15155 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Y2H Array
32296183
Intra
BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Validated Y2H
32296183
Intra
BET1 O15155 LYPD5 Homo sapiens Q6UWN5
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Validated Y2H
32296183
Intra
BET1 O15155 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
BET1 O15155 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Validated Y2H
32296183
Intra
BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
BET1 O15155 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
BET1 O15155 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
BET1 O15155 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
BET1 O15155 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
BET1 O15155 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
BET1 O15155 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
BET1 O15155 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
BET1 O15155 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
BET1 O15155 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
BET1 O15155 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
BET1 O15155 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
BET1 O15155 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
BET1 O15155 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
BET1 O15155 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Validated Y2H
32296183
Intra
BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
Intra
BET1 O15155 ADORA2A Homo sapiens P29274
Y2H Prey Pooling
32296183
Intra
BET1 O15155 ADORA2A Homo sapiens P29274
Validated Y2H
32296183
Intra
BET1 O15155 ADORA2A Homo sapiens P29274
Y2H Array
32296183
Intra
BET1 O15155 NAPB Homo sapiens Q9H115
Validated Y2H
32296183
Intra
BET1 O15155 GOSR2 Homo sapiens O14653
Pull Down
29568061
Intra
BET1 O15155 GOSR2 Homo sapiens O14653
Y2H Prey Pooling
32296183
Intra
BET1 O15155 GOSR2 Homo sapiens O14653
Anti Tag CoIP
33961781
Intra
BET1 O15155 GOSR2 Homo sapiens O14653
BioID
29568061
Intra
BET1 O15155 GOSR2 Homo sapiens O14653
Y2H Array
32296183
Intra
BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
BET1 O15155 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
BET1 O15155 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
BET1 O15155 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
BET1 O15155 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
BET1 O15155 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
BET1 O15155 ANKS6 Homo sapiens Q68DC2
Validated Y2H
32296183
Intra
BET1 O15155 ANKS6 Homo sapiens Q68DC2
Y2H Array
32296183
Intra
BET1 O15155 ANKS6 Homo sapiens Q68DC2
Y2H Prey Pooling
32296183
Intra
BET1 O15155 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
BET1 O15155 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
BET1 O15155 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
BET1 O15155 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
BET1 O15155 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
BET1 O15155 USHBP1 Homo sapiens Q8N6Y0
Pull Down
16189514
Intra
BET1 O15155 USHBP1 Homo sapiens Q8N6Y0
Y2H Pooling
16189514
Intra
BET1 O15155 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
BET1 O15155 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
BET1 O15155 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
BET1 O15155 STX4 Homo sapiens Q12846
Validated Y2H
25416956
Intra
BET1 O15155 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra
BET1 O15155 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra
BET1 O15155 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
BET1 O15155 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
BET1 O15155 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra
BET1 O15155 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
BET1 O15155 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
BET1 O15155 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
BET1 O15155 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
BET1 O15155 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
BET1 O15155 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
BET1 O15155 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
BET1 O15155 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
BET1 O15155 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Intra
BET1 O15155 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
BET1 O15155 STX1B Homo sapiens P61266
Y2H Prey Pooling
32296183
Intra
BET1 O15155 STX1B Homo sapiens P61266
Validated Y2H
32296183
Intra
BET1 O15155 STX1B Homo sapiens P61266
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Citrullinemia, Type Ii, Neonatal-Onset

  • NICCD

  • Citrin Deficiency

  • Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency

  • Citrullinemia, Type Ii, Neonatal-Onset, With Or Without Failure To Thrive And Dyslipidemia

  • Cholestasis, Neonatal Intrahepatic, Caused By Citrin Deficiency

  • Neonatal-Onset Type Ii Citrullinemia

  • Neonatal Intrahepatic Cholestasis Caused By Citrin Deficiency

  • Neonatal-Onset Citrullinemia Type 2

  • Neonatal-Onset Citrullinemia Type Ii

  • Neonatal-Onset Type 2 Citrullinemia

  • Adult-Onset Citrullinemia Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135250B Thalidomide-4-O-C6-NH2 hydrochloride Inducer 99.11% Unkown
HY-142265 NVS-BET-1 Inhibitor / Unkown
HY-135250A Thalidomide-4-O-C6-NH2 TFA Inducer / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-157749 Thalidomide-piperazine-(S)-CH2-pyrrolidine-C2-O-CH2-COO-C(CH3)3 Inducer / Unkown
HY-RS01478 BET1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01479 BET1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20695 Bet1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27206 Bet1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BET1 VGNC VGNC:26475
Rattus norvegicus BET1 RGD RGD:2203
Mus musculus BET1 MGD MGI:1343104
Macaca mulatta BET1 VGNC VGNC:80799
Others BET1 NCBI