REEP4 - receptor accessory protein 4 Gene

Also Known as PP432; Yip2c; C8orf20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80346

Summary

Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in skin (RPKM 22.1), testis (RPKM 16.1) and 23 other tissues.

REEP4 Products (3)

mRNA Protein Name
NM_001316964.2 NP_001303893.1 receptor expression-enhancing protein 4 isoform 2
NM_001316965.2 NP_001303894.1 receptor expression-enhancing protein 4 isoform 3
NM_025232.4 NP_079508.2 receptor expression-enhancing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic nuclear membrane reassembly IMP
IMP: Inferred from mutant phenotype
23911198 GOA
involved in nuclear envelope organization IMP
IMP: Inferred from mutant phenotype
23911198 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23911198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REEP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REEP4 Q9H6H4 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 TVP23B Homo sapiens Q9NYZ1
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 SFXN3 Homo sapiens Q9BWM7
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 TIMM22 Homo sapiens Q9Y584
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 LNPEP Homo sapiens Q9UIQ6-2
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 LEMD3 Homo sapiens Q9Y2U8
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 SFXN1 Homo sapiens Q9H9B4
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 SFN Homo sapiens P31947
TAP
15778465
Intra
REEP4 Q9H6H4 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 TMEM65 Homo sapiens Q6PI78
Y2H Array
32296183
Intra
REEP4 Q9H6H4 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra
REEP4 Q9H6H4 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11813 REEP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11814 REEP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11815 REEP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11816 REEP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11817 REEP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown