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AGPAT4 - 1-acylglycerol-3-phosphate O-acyltransferase 4 Gene

Also Known as LPAAT4; LPLAT4; 1-AGPAT4; dJ473J16.2; LPAAT-delta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56895

About AGPAT4

Cytogenetic location: 6q26 Genomic coordinates (GRCh38): 6:161,129,967-161,274,061 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 4 paralogues. Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues.

Summary

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]

AGPAT4 Products (1)

mRNA	Protein	Name
NM_020133.3	NP_064518.1	1-acyl-sn-glycerol-3-phosphate acyltransferase delta

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGPAT4 Protein Structure

Acyltransferase

0
100
200
300
378 a.a.

Protein Preferred Names	Protein Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta	1-AGP acyltransferase 4

AGPAT4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGPAT4	Q9NRZ5	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	AGPAT4	Q9NRZ5	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	FCGR2A	Homo sapiens	P12318-2	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	FCGR2A	Homo sapiens	P12318-2	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	AGPAT4	Q9NRZ5	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	AQP12B	Homo sapiens	A6NM10-2	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	AQP12B	Homo sapiens	A6NM10-2	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	FCRL3	Homo sapiens	Q96P31-6	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	FCRL3	Homo sapiens	Q96P31-6	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	GPR101	Homo sapiens	Q96P66	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	GPR101	Homo sapiens	Q96P66	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	AGPAT4	Q9NRZ5	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	AGPAT4	Q9NRZ5	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	AGPAT4	Q9NRZ5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	AGPAT4	Q9NRZ5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	AGPAT4	Q9NRZ5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fetal Akinesia Deformation Sequence 4	FADS4 Fetal Akinesia Deformation Sequence Syndrome 4 Akinesia, Fetal, Deformation Sequence, Type 4
Complete Generalized Lipodystrophy
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Fetal Akinesia Deformation Sequence 1	Fetal Akinesia Deformation Sequence Fads Fetal Akinesia Sequence FADS1 Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia Pena-Shokeir Syndrome Type 1 Fetal Akinesia Deformation Sequence Syndrome Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia Pena-Shokeir Syndrome, Type I Foetal Akinesia Deformation Sequence Syndrome Foetal Akinesia Sequence Fetal Akinesia Deformation Sequence Syndrome 1 Pena-Shokeir Syndrome, Type 1 Pena Shokeir Syndrome, Type 1 Akinesia, Fetal, Deformation Sequence Akinesia, Fetal, Deformation Sequence, Type 1 Pena-Shokeir Syndrome Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175646	AGPAT4-IN-1		99.04%	Unkown
HY-RS00459	AGPAT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21089	Agpat4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27607	Agpat4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AGPAT4	VGNC	VGNC:59687
Canis familiaris	AGPAT4	VGNC	VGNC:37713
Bos taurus	AGPAT4	VGNC	VGNC:25737
Macaca mulatta	AGPAT4	VGNC	VGNC:69654
Mus musculus	AGPAT4	MGD	MGI:1915512
Rattus norvegicus	AGPAT4	RGD	RGD:619916
Others	AGPAT4	NCBI