SPACA1 - sperm acrosome associated 1 Gene

Homo sapiens

Also known as SAMP32

Gene ID: 81833 | Gene type: protein coding

About SPACA1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:88,046,901-88,066,838 (from NCBI)

This gene has 3 transcripts (splice variants) and 116 orthologues. Restricted expression toward testis (RPKM 11.4).

Summary

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm Antibodies from infertile males. Furthermore, Antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

SPACA1 Products(1)

mRNA	Protein	Name
NM_030960.3	NP_112222.1	sperm acrosome membrane-associated protein 1 precursor

Protein Preferred Names

Protein Names

sperm acrosome membrane-associated protein 1

sperm acrosomal membrane-associated protein 32

Related Diseases

Diseases

Alias

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Atrophy Of Prostate

Chronic Salpingitis

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13615	SPACA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPACA1	MGD	MGI:1914902
Macaca mulatta	SPACA1	VGNC	VGNC:77924
Rattus norvegicus	SPACA1	RGD	RGD:1560284
Felis catus	SPACA1	VGNC	VGNC:65590
Bos taurus	SPACA1	VGNC	VGNC:35161
Canis familiaris	SPACA1	VGNC	VGNC:46692

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